The scoreboard is going to get a workout Monday night as the Detroit Lions, fresh off a 52-point Week 2 outing, travel to Baltimore to take on Lamar Jackson and the high-powered Baltimore Ravens.
The total has hit 53.5, making it the highest O/U of any game so far in 2025.
While everyone is crowning Josh Allen the league MVP, Jackson is still stuffing the statsheet, and that's not going to change in my Lions vs. Ravens predictions.
Find out more in my NFL picks for September 22, with kickoff set for 8:15 p.m. ET on ESPN.
Lions vs Ravens prediction
Lions vs Ravens Best bet: Lamar Jackson Over 38.5 yards longest completion (-115)
The Baltimore Ravens have the most explosive offense in football, ranking No. 1 in explosive play rate at 17.3%.
That’s bad news for a Detroit Lions defense giving up big plays at an alarming rate — 28th in explosive play rate allowed (13%). While Baltimore’s ground game stumbled last week against Cleveland, Lamar Jackson remains fully capable of chunk gains through the air.
Jackson has hit the Over on his longest completion prop in eight of his last 10 games (including playoffs), and in seven of those, he connected on passes of 40+ yards. Zay Flowers has emerged as a legit top-10 WR, and DeAndre Hopkins is making his deep looks count with recent gains of 29 and 41 yards.
Detroit has to respect the run, but Baltimore’s play-action game is elite — ranking No. 1 in EPA/play — while the Lions sit just 19th defending play action. That’s a clear edge for Jackson to keep attacking vertically.
This game carries the highest total on the Week 3 slate, and it sets up as a shootout. The last time these teams met in 2023, Jackson torched the Lions for 357 yards and three touchdowns, completing six passes of 20+ yards, including strikes of 46 and 80 yards.
The deep shots will be there again on MNF.
Lions vs Ravens MNF same-game parlay
Let’s go touchdown-heavy with the Monday Night SGPs. The most popular one on bet365 includes Derrick Henry, Jahmyr Gibbs, Flowers, and Amon-Ra St. Brown—currently listed at +875. But I prefer a tighter, higher-upside three-leg version.
Jackson has been pass-heavy in the red zone, which boosts his scramble TD equity. I’d much rather back Jackson at +130 than Henry at -250, who barely moves the needle in a parlay.
Flowers is locked in with over a 40% target share—one of just three WRs in the league hitting that mark. He stays in the mix.
To round it out, I’m adding Jameson Williams. He’s the clear WR2 in Detroit now, running 100% of routes in Week 2 and coming off a 108-yard game on just two catches.
With multiple Ravens defensive starters questionable, Jamo has the speed to take one to the house—just like Keon Coleman did in Week 1 against this secondary.
Lions vs Ravens 3-leg SGP
- Zay Flowers anytime touchdown
- Jameson Williams anytime touchdown
- Lamar Jackson anytime touchdown
Our big-ticket SGP: 4 of a Kind
David Montgomery has been the one getting the valuable goal-line work — three carries inside the 5-yard line compared to zero for Gibbs.
At +115, Montgomery looks like the better value between the Detroit backs.
Tylan Wallace also stands out at +550. He’s running the third-most routes among Ravens WRs, with Baltimore using 3-WR sets around 50% of the time.
Last week, he played 50% of snaps with a 47% route share — both increases — and turned that into two catches and a TD.
Baltimore’s lower-end receivers combined for four TDs last week, as the team showed little interest in running near the goal line.
Lions vs Ravens 4-leg SGP
- Zay Flowers anytime touchdown
- Jameson Williams anytime touchdown
- Tylan Wallace anytime touchdown
- David Montgomery anytime touchdown
Lions vs Ravens odds
- Spread: Detroit +4.5 (-110) | Baltimore -4.5 (-110)
- Moneyline: Detroit +185 | Baltimore -225
- Over/Under: Over 53.5 (-110) | Under 53.5 (-110)
Lions vs Ravens betting trend to know
Baltimore has hit the team total Over in 18 of its last 22 games (+13.55 Units / 50% ROI). Find more NFL betting trends for Lions vs. Ravens.
How to watch Lions vs Ravens
| Location | M&T Bank Stadium, Baltimore, MD |
| Date | Monday, September 21, 2025 |
| Kickoff | 8:15 p.m. ET |
| TV | ESPN |
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