Expert NFL Combo Picks for Week 6

Week 6 rolls into Sunday with a packed slate and plenty of ways to build a winning card.

From game outcomes to player props, our experts have identified several sharp angles worth adding to your NFL Week 6 parlays.

Check out our latest NFL picks, featuring top matchup breakdowns and high-value combo legs for Sunday's full slate.

NFL combo picks for Week 6

For help understanding Kalshi probabilities, please see our odds calculator.

Matchup	Pick
Texans vs Jaguars	Jaguars moneyline Lawrence 225+ passing yards Marks 15+ rushing attempts	5.10x
Saints vs Giants	Giants moneyline Skattebo anytime touchdown Nabers 70+ receiving yards	7.17x
Titans vs Colts	Pollard Over 59.5 rushing yards Titans +6.5 Under 44.5	7.69x
Panthers vs Eagles	Panthers -3.5 Under 39.5 Panthers score first	4.80x
Bears vs Falcons	Falcons moneyline Under 53.5 Pitts Sr. Over 2.5 receptions	4.12x
Jets vs Patriots	Under 43.5 Jets +7.5 Stevenson Over 62.5 rushing yards	6.70x
Steelers vs Buccaneers	Buccaneers +2.5 Irving anytime touchdown Egbuka 40+ receiving yards	10.50x
Ravens vs Browns	Ravens moneyline Over 39.5 Andrews Over 3.5 receptions	5.40x
Cardinals vs Rams	Rams -12.5  Over 51.5 Williams anytime touchdown	5.62x
Bills vs Raiders	Bills -4.5 Allen 250+ passing yards Allen 30+ rushing yards	7.25x
Chargers vs Chiefs	Chiefs -7.5 Walker Anytime Touchdown Worthy Anytime Touchdown	5.25x
Cowboys vs Packers	Over 53.5 Prescott 275+ passing yards Golden anytime touchdown	7.17x
Commanders vs 49ers	Daniels anytime TD Purdy anytime TD	14.00x

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Expert NFL combo picks for Week 6

Texans vs Jaguars: 5.10x

Jaguars quarterback Trevor Lawrence has thrown for a career-high 8.2 yards per attempt and a 67.1 completion percentage, and he also ranks eighth in adjusted EPA per play.

The Texans have also posted middling ranks against the pass, with a 16th-ranked pass defense DVOA. They sit 19th in EPA per dropback, and Lawrence has aired it out for 558 yards the past two weeks.

Turning to Houston running back Woody Marks, he’s set for a lead role with David Montgomery (groin) sidelined, and Marks rushed for a respectable 4.1 yards per carry for 62 total in Week 5. 

Additionally, Texans head coach DeMeco Ryans praised the second-year back’s play and confirmed Marks would be heavily involved again this week.

Check out full Texans vs. Jaguars predictions.

Saints vs Giants: 7.17x

This combo cashes if New York’s best offensive players drive the win.

Giants WR Malik Nabers can keep drives alive and stretch New Orleans’ secondary, giving QB Jameis Winston an easy first option whenever NYG needs a play.

If Nabers piles up yardage, New York will be in position for Cam Skattebo to finish drives near the goal line.

That’s the connection between all three legs. Nabers moves the offense, Skattebo cashes in scoring opportunities, and the Giants turn those possessions into enough points to win at home.

If New York’s offense runs through those two, the moneyline should take care of itself.

Check out full Saints vs. Giants predictions.

Titans vs Colts: 7.69x

A Tennessee cover should correlate with an ugly, lower-scoring game, so I'm pairing Titans +6.5 with Under 44.5 and RB Tony Pollard 60+ rushing yards.

Tennessee needs to shorten this game and keep QB Cam Ward out of obvious passing situations. That means establishing the run with Pollard against an Indianapolis defense ranked 27th in yards per rush allowed. That ground-heavy approach helps the Under.

Neither offense has been trustworthy on late downs, and Tennessee and Indianapolis are tied for 24th in third-down conversion rate. A competitive game featuring long possessions, field goals, and limited explosive passing plays is exactly what I'm looking for.

Check out full Titans vs. Colts predictions.

Panthers vs Eagles: 4.80x

The Panthers scored 37 points against the Bears, whose defense ranks four spots better than the Eagles, and 34 against the Falcons, who are 10 spots better. Philadelphia ranks 22nd in EPA/play on defense and 22nd on defensive success rate.

The Panthers are 10th in the league in red zone touchdown percentage, cashing in at a rate seven percentage points higher than last season. So look for Carolina to get an early six.

The total has dropped two points since the Hurts news broke, which probably still is too high. Philadelphia isn’t going to score enough to do its part to get this game Over.

Check out full Panthers vs. Eagles predictions.

Bears vs Falcons: 4.12x

I'm targeting a Falcons victory at home, but I also I’m leaning Under 53.5 with both quarterbacks carrying some injury-related uncertainty and Atlanta likely leaning heavily on Robinson and the ground game. That should help shorten the contest, while Chicago’s offense may also be more conservative if Williams returns at less than 100%.

If Tyson Bagent does start, that strengthens the under narrative immensely, as he's yet to throw for a touchdown in 64 pass attempts. 

I'll round out this combo with Kyle Pitts Sr. to make just three catches. Chicago is allowing 3.6 receptions per game to opposing tight ends, while Pitts has caught eight passes over his last two contests. With his target volume also trending upward, he has a reasonable path to three grabs. 

Check out full Bears vs. Falcons predictions.

Jets vs Patriots: 6.70x

I'm not expecting many points in this game, and on its face, that makes me suspicious of a spread of more than a touchdown. Even in the Jets' three losses this year, they've only lost by more than one score once in a 23-12 defeat to the Chicago Bears. I'm taking New York to cover.

One area where the Patriots might consistently succeed is the running game, where the Jets allow 4.2 yards per rush. Rhamondre Stevenson is coming off a 64-yard performance against the Las Vegas Raiders last week, and I see him hitting the 60+ yard target on the ground again on Sunday.

Check out full Jets vs. Patriots predictions.

Steelers vs Buccaneers: 10.50x

Tampa Bay doesn’t need to dominate this game for the combo to cash. It just needs QB Jalon Daniels to keep the offense moving and avoid putting the defense in bad spots.

Buccaneers wideout Emeka Egbuka should be a big part of that. If he keeps commanding targets and creating manageable downs, Tampa can sustain drives instead of constantly punting the ball back to Pittsburgh. That gives running back Bucky Irving more chances to finish possessions near the goal line.

The script is pretty simple: Egbuka helps move the chains, Irving cashes in one of those scoring opportunities, and the Buccaneers stay competitive enough throughout to cover the spread or win outright.

Check out full Steelers vs. Buccaneers predictions.

Ravens vs Browns: 5.40x

The Ravens have scored 24+ points in each of their wins this year, and this line feels too low despite Jackson being sidelined. The Over is 7-3 in Baltimore’s last 10 games, and it’s been a winning ticket in the past five meetings between these teams.

With Cleveland sweating on the health of key defensive playmakers, Huntley can deliver a similar stat line to his SNF effort against the Falcons (201 passing yards, two TD passes, no turnovers), while the Browns’ offense is boosted by KC Concepcion clearing the concussion protocol.

When Baltimore isn’t riding Henry and the ground game, look for Mark Andrews to be a key checkdown option for Huntley. Andrews has 22 catches through five contests, and he’s finished with 6+ targets in four of those outings.

Check out full Ravens vs. Browns predictions.

Cardinals vs Rams: 5.62x

Los Angeles can do most of the heavy lifting for this combo. If the Rams jump on Arizona early, Brissett will have to chase points while Matthew Stafford and the offense keep creating scoring opportunities. Los Angeles is 4-0 to the Over in its last four games against teams with a losing record.

Eventually, Rams RB Kyren Williams will be in position to finish drives and help Los Angeles protect a comfortable lead on the ground. Williams has five total touchdowns in five games this season (four rushing and one receiving).

Arizona doesn't need to turn this into a shootout, either. A couple of Cardinals touchdowns should be enough, as I'm expecting the Rams to put up points in the mid-30s.

Check out full Cardinals vs. Rams predictions.

Bills vs Raiders: 7.25x

Josh Allen has aired it out for a high-end 9.1 yards per attempt and a 9.6 aDoT through five weeks, and he’s ran for 5.6 yards per carry, including 3.67 yards after contact per carry. 

It's also the perfect matchup for one of the betting favorites in the NFL MVP odds to pad his stat line, with the Raiders allowing 8.1 YPA and 6.1 yards per carry to QBs during the noted three-week stretch.

Check out full Bills vs. Raiders predictions.

Chargers vs Chiefs: 5.25x

Given that I expect a low-scoring game, I'm going to be cautious and play a three-leg parlay on the Chiefs here. I do love two touchdown scorers for the home team, though.

Kenneth Walker has scored six touchdowns across three of his four games this season. Xavier Worthy is also tied for second in red zone targets behind Walker and offers a serious RZ threat.

Check out full Chargers vs. Chiefs predictions.

Cowboys vs Packers: 7.17x

It’s really Over or nothing when it comes to this total. We have two excellent quarterbacks who love to look downfield, a wealth of wide receiver talent, and two defenses that are missing bodies in the secondary. 

Dak Prescott is one of the best QBs against zone defense and faces a lot of that in Green Bay. He has to carry the Cowboys with his big arm and is a notable jump in QB competition for a Packers defense missing key bodies in Week 6.

Matthew Golden isn’t just a threat to take the top of this soft Cowboys secondary, but he’s also drawn the most red-zone targets among the Cheeseheads’ receivers. Touchdown forecasts sit as high as 53% on SNF.

Check out full Cowboys vs. Packers predictions.

Commanders vs 49ers: 14.00x

I'm running the double quarterback touchdown combo every Monday night, and this might be the most optimistic I've been all season, as both Brock Purdy and Jayden Daniels are carrying legitimate scoring probabilities.

Purdy has rushed for 29+ yards in all but one game this season (4-1 O/U on his rushing total) and scored once, while Daniels showed last week that he's not afraid to run following his elbow injury, totaling two rushing TDs and 103 yards on the ground. Both TDs are +EV, per the projections at their current prices.

Four quarterbacks have scored on Monday night through five games, and this TD system already cashed at 14x in Week 3.

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