Chargers vs Chiefs Prediction, Picks & Odds: NFL Week 6

Sam Farley - Contributor at Covers.com
Sam Farley • Betting Analyst 10+ years betting experience
Updated: Oct 17, 2026 , 09:23 AM ET • 4 min read

Xavier Worthy should see plenty of targets with Rashee Rice sidelined.

nfl

Match starts: 25 hrs
Xavier Worthy of the Kansas City Chiefs NFL
Photo By - Reuters Connect. Kansas City Chiefs wide receiver Xavier Worthy (1) carries the ball for a touchdown. Denny Medley-Imagn Images.

Sunday brings an interesting divisional battle as the Los Angeles Chargers face the Kansas City Chiefs at Arrowhead, with the hosts unbeaten and the visitors still without a win. 

The Chiefs are 7.5-point favorites and have a 78% chance to win. Tune in on Sunday, Oct. 18, with kickoff at 4:25 p.m. ET on CBS.

My Chargers vs. Chiefs prediction is that the Chargers' low-scoring offense will keep the game total Under.

Don't forget to check out the rest of our NFL picks for Sunday's slate.

Chargers vs Chiefs prediction: Under 41.5

I'm confident in a Kansas City Chiefs win, but the spread concerns me, so I'm tackling the Under because I'm not confident in the Los Angeles Chargers' offense.

This unit ranks 32nd in EPA per play and 32nd in EPA per drive. The passing game hasn't gotten going under Mike McDaniel, defying preseason expectations.

The Chargers rank 32nd in Pass EPA per play, and even the rushing game, a cornerstone of the Jim Harbaugh philosophy, isn't working, with a 19th-place success rate in the NFL. The biggest issue is the offensive line, a unit missing key pieces, and the remaining pieces are still underperforming.

The Under is 7-1 in the Chargers' past eight games, and despite this Chiefs offense looking impressive, it won't be enough to push the total high enough to cover, especially with Rashee Rice out.

Covers COVERS INTEL: The Los Angeles Chargers have only allowed seven passing touchdowns this season. 
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Chargers vs Chiefs combo

Given that I expect a low-scoring game, I'm going to be cautious and play a three-leg parlay on the Chiefs here. I do love two touchdown scorers for the home team, though.

Kenneth Walker has scored six touchdowns across three of his four games this season. Xavier Worthy is also tied for second in red zone targets behind Walker and offers a serious RZ threat.

Chargers vs Chiefs combo

  • Chiefs -7.5
  • Kenneth Walker Anytime Touchdown
  • Xavier Worthy Anytime Touchdown

 TOP PICK
Chargers vs Chiefs player prop: Xavier Worthy Over 4.5 receptions 

It still feels like things haven't really worked out for Xavier Worthy at the Chiefs yet, but they clearly believe in him because they keep trying to get the ball into his hands.

In their last game, he caught four of seven targets for an impressive 115 air yards. He's had six or more targets in all but one game this season, and with Rice sidelined, he should get a lot of targets on Sunday.

Want more NFL player props? Check out our NFL player prop projections!

Sam Farley's 2026 Transparency Record
  • Top picks: 0-1, -1.00 units
  • Combos: 0-1 -1.00 units
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Chargers vs Chiefs odds

For help understanding probabilities, see our odds calculator.

  • Spread: Chargers +7.5 | Chiefs -7.5
  • Over/Under: Over 41.5 (49%) | Under 41.5 (52%)
  • Moneyline: Chargers 22% | Chiefs 78%

For the full slate of NFL matchups, check out our NFL odds board!


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Chargers vs Chiefs weather

The conditions at Arrowhead will be fine, with temperatures in the mid-60s, clouds, and 10 mph winds.

Check out our NFL weather page for up-to-date info on every matchup.

Chargers vs Chiefs trend to know

The Under is 5-0 in the previous five meetings between the teams in Kansas City. Find more NFL betting trends for Chargers vs. Chiefs.

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How to watch Chargers vs Chiefs

Location Arrowhead Stadium, Kansas City, Mo.
Date Sunday, Oct. 18, 2026
Kickoff 4:25 p.m. ET
TV CBS

Chargers vs Chiefs latest injuries

Check out our NFL injuries page for updates on every team. 

Odds are correct at the time of publishing and are subject to change.
Not intended for use in MA.
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Sam Farley
Betting Analyst

Sam is based in the United Kingdom, where he grew up living and breathing soccer, before discovering - and playing - a different kind of football at the University of Bristol. He’s worked in the media covering soccer and the NFL for the better part of a decade, and has been a regular on the Matchbook NFL Podcast. His work has also appeared in a wide range of publications including The Telegraph, The Independent, VICE, and MSN.

The search for great betting value is a daily one, and Sam always hunts out big prices with a particular focus on player props. Sam’s best advice for bettors is to track their bets on a spreadsheet, that way you can keep an eye on your P&L but also the types of bets and sports that you are most successful in. He also recommends using a variety of different sportsbooks, with bet365, Betfair and Paddy Power amongst his favorites.

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