The 5-1 Indianapolis Colts keep on winning and will now return to the site of their lone loss this season — SoFi Stadium — to take on the 4-2 Los Angeles Chargers. Kickoff is at 4:05 p.m. ET on CBS.
L.A., which is favored by 2.5 points with an Over/Under of 48.5, has struggled to stop the run this year, and my Colts vs. Chargers predictions believe that could spell trouble against one of the league’s best backs.
Read on for more in my NFL picks for Sunday, October 19.
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Colts vs Chargers prediction
Colts vs Chargers Best bet: Jonathan Taylor Over 87.5 rushing yards (-114)
Indianapolis Colts running back Jonathan Taylor enters Week 7 leading the NFL in rushing with 603 yards. That is an average of 100.5 yards per game on the ground, and he also averages a whopping 5.2 yards per carry despite leading the NFL in rush attempts.
The Los Angeles Chargers have the 21st-ranked run defense, allowing 124.2 yards per contest.
However, they are even worse in defending specific types of runs, ranking last in the NFL in defending the rush with a light box, 31st in defending runs out of shotgun formations, and 24th in defending designed runs.
Meanwhile, the Colts rank seventh, ninth, and first in the NFL in those respective categories on offense. Taylor has forced a league-high 41 missed tackles across his 135 touches this season, recording 239 yards after forcing missed tackles.
The Chargers have recorded the second-highest missed tackle rate and allowed the second-most yards after missed tackles this season.
This game should be competitive, and Taylor will get plenty of opportunities to touch the ball. He has hit the century mark on the ground three times this season and this is an excellent chance for him to do so for a fourth time.
Colts vs Chargers same-game parlay
To add to my best bet, I am going to add the Over, as the Colts offense continues to light up scoreboards, and the Chargers allowed 27 points in each of their last two games.
Finally, I am taking Taylor to the end zone twice in this contest. The Chargers have allowed seven rushing touchdowns this season, and Taylor has two multi-score games this season.
Colts vs Chargers 3-leg SGP
- Jonathan Taylor Over 87.5 rushing yards
- Jonathan Taylor 2+ touchdowns
- Over 48.5
Our big-ticket SGP: Happy feet
The Colts will get plenty of pressure on Justin Herbert with injuries to the tackles, and Herbert will take off enough to hit his rushing total.
Colts vs Chargers 4-leg SGP
- Jonathan Taylor Over 87.5 rushing yards
- Jonathan Taylor 2+ touchdowns
- Justin Herbert Over 15.5 rushing yards
- Over 48.5
Colts vs Chargers odds
- Spread: Colts +2.5 (-110) | Chargers -2.5 (-110)
- Moneyline: Colts +118 | Chargers -138
- Over/Under: Over 48.5 (-110) | Under 48.5 (-110)
Colts vs Chargers game predictions
Colts vs Chargers moneyline prediction
The Indianapolis Colts will avenge their lone loss of the season at SoFi by beating an injured Los Angeles Chargers team that struggles to stop the run.
Colts vs Chargers spread prediction
The Chargers have failed to cover the spread in each of their last four games after a hot start, mostly due to their slew of injuries.
Colts vs Chargers Over/Under prediction
Most of the sharp money is on the Over here, with 50% of the money on the Over despite only 39% of the bets.
More NFL picks and odds from Covers
Colts vs Chargers trend to know
The Colts have hit the Over in six of their last 10 away games, and the Chargers have hit the Over in seven of their last 10 games at home. Find more NFL betting trends for Colts vs. Chargers.
How to watch Colts vs Chargers
| Location | SoFi Stadium, Los Angeles, CA |
| Date | Sunday, October 19, 2025 |
| Kickoff | 4:05 p.m. ET |
| TV | CBS |
Colts vs Chargers latest injuries
Colts vs Chargers weather
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