The Los Angeles Chargers and Jacksonville Jaguars will meet in Jacksonville this Sunday, with the Chargers' visitors favored to win.
The Chargers are looking good right now and should be able to take down a Jaguars team that blew a huge lead against the Texans last week.
Don’t miss our Chargers vs. Jaguars predictions and NFL picks for November 16.
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Chargers vs Jaguars prediction
Chargers vs Jaguars Best bet: Chargers -3 (-105)
In our early week picks and predictions, we advised taking the Los Angeles Chargers -2.5, and that hasn’t changed as the line has grown by half a point.
This is very much the case of a team that is showing real signs of improvement week after week, facing a team that is struggling.
The Jacksonville Jaguars are low on confidence following their embarrassing loss to the Texans last Sunday, in which they allowed Texans’ backup Davis Mills to score 26 unanswered points in the fourth quarter.
This defense is giving up the fifth most yards per game against the pass, a high 252.9 yards allowed every Sunday. After a hot start to the season, they’re starting to slow down.
We haven’t seen much real improvement for Trevor Lawrence under Liam Coen and he’s as erratic as ever, and Travis Hunter is now on IR, just as he was starting to take the WR1 spot.
Meanwhile, the Chargers are 7-3 in the AFC West, have covered in two of their previous three games, and feature an offense that is hugely improved from earlier in the season.
They’ve scored an average of 8.8 more points per game in the previous five games, as they did in the first five games of the season.
Chargers vs Jaguars same-game parlay
In addition to our best bet, we’re going to back Keenan Allen to have over 37.5 receiving yards. Allen has covered his prop number in six of 10 this season.
Finally, we’re taking Oronde Gadsden to score a touchdown. The Jaguars have allowed seven TDs to tight ends in nine games, and with Gadsden averaging two red zone targets per game, he’s the play.
Chargers vs Jaguars SGP
- Chargers -3
- Keenan Allen Over 41.5 receiving yards
- Oronde Gadsden anytime touchdown
Our big-ticket SGP: Allen Wrench!
Allen has four touchdowns this season and leads the team in those valuable red zone targets, plus has the added potential of an increase in targets if McConkey or Johnston are out.
Chargers vs Jaguars SGP
- Chargers -3
- Keenan Allen Over 41.5 receiving yards
- Oronde Gadsden anytime touchdown
- Keenan Allen anytime touchdown
Chargers vs Jaguars odds
- Spread: Chargers -1.5 (-110) | Jaguars +1.5 (-110)
- Moneyline: Chargers -125 | Jaguars +105
- Over/Under: Over 44.5 (-110) | Under 44.5 (-110)
More NFL picks and odds from Covers
Chargers vs Jaguars trend to know
The Los Angeles Chargers have hit the 3Q Game Total Over in 14 of their last 19 games. Find more NFL betting trends for Chargers vs. Jaguars.
How to watch Chargers vs Jaguars
| Location | Mercedes-Benz Stadium, Atlanta, GA |
| Date | Sunday, November 16, 2025 |
| Kickoff | 1:00 p.m. ET |
| TV | FOX |
Chargers vs Jaguars latest injuries
Chargers vs Jaguars weather
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