There's no shortage of options for making college football combos with Week 1 continuing into Sunday.
Our college football picks are here to help you sort through the contenders and pretenders and present the best value on the board.
See why Louisville can make Mississippi's season opener tougher than expected and more below.
Best college football combos for Week 1
For help understanding probabilities, please see our odds calculator.
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Sunday, Sept. 6
Best Washington vs Washington State combo
Washington State covering is tied to its veteran defense pushing Washington's young offensive line and taking advantage of how long Williams tends to hold the ball. His time to throw last year was higher than any P4 QB that took 300+ dropbacks (3.21 seconds).
If the Cougars can pressure Williams enough to hold Washington to 35 or fewer points, Wazzu will be in good shape, but the Under will be in even better shape. The Huskies' defense was 10th in EPA per rush last season and 13th in early-down EPA per play, while ranking 27th in returning production (61%).
With proven talent back on defense, the Huskies should slow Wazzu's offense. The Cougars are starting former UC Davis QB Caden Pinnick, who Washington held to 10 points last year when the Huskies played the Aggies.
Check out our full Washington vs. Washington State predictions.
Best Wisconsin vs Notre Dame combo
There's excitement around Wisconsin's offense with Joseph starting, but it's a huge ask for him to produce against Notre Dame in his first start as a P4 QB.
Notre Dame has the best defensive player in the country (Leonard Moore) leading the best secondary in the country, with a front seven that features multiple projected NFL draft picks, including potential Top 50 selection Boubacar Traore.
Traore and the Irish D-line will create havoc against a Badgers O-line dealing with injuries and new starters. That spells trouble for Joseph, who was a big-play hunter at Old Dominion.
While he looked to hit home runs, it led to him missing out on singles and doubles. Joseph had the second-lowest adjusted completion percentage in the country among the 99 QBs who took 300+ dropbacks in 2025 (65.1).
Check out our full Wisconsin vs. Notre Dame predictions.
Best Louisville vs Mississippi combo
Simply put, Under bets correlate with underdogs for obvious reasons. Although I'm less confident in the Under leg in my combo, this is a national TV game, which could lead to tightness for both teams. Also, the Under is 4-1 in Louisville's last five games as an underdog.
Check out our full Louisville vs. Mississippi predictions.
Odds are correct at the time of publishing and are subject to change.
Not intended for use in MA.
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