The page turns to Week 4 of the 2025 college football season, and we have you covered with the best player props to bet.
Will Cade Klubnik and the Clemson Tigers bounce back on offense? Is Oklahoma’s new-look offense for real? Can Duke’s passing attack keep up the torrid pace?
Find out the answers with my college football picks and player props for the afternoon games on Saturday, September 20.
Best college football player props for Week 4's early slate
Klubnik o2.5 passing touchdowns (+118)
Burks o63.5 receiving yards (-114)
Brown o48.5 receiving yards (-114)
Prop bet #1: Cade Klubnik Over 2.5 passing touchdowns
If there ever was a bounceback spot for this stumbling Clemson Tigers offense, it’s this week’s home matchup with the Syracuse Orange. Fran Brown’s squad looked to be a poor defensive unit heading into the season, and pretty much every result has backed up that notion thus far.
Cuse is allowing 29.7 ppg and 439 total yards per game, and the eye test might be even worse. The advanced metrics don’t love Cuse’s defense either (113th in EPA per play and 109th in success rate).
Teams typically thrive against Clemson’s RPO offense when they can blow plays up and get in the backfield, messing with the exchange and quickening up the quarterback’s process. The Orange are uniquely ill-equipped to do that, ranking 128th in front seven havoc. Simply put, this is a smash spot for the Clemson offense.
It hasn’t been the season that Clemson expected, but let’s be realistic about where things stand. This was one of the most productive offenses in the country last year, and Dabo Swinney’s squad returned almost all of the key players. They squashed overmatched ACC teams in 2024 and should do so again in 2025 now that the schedule has lightened up.
I envision a big game from Cade Klubnik, who will have all day to throw. He’ll find the end zone several times while Dabo keeps his foot on the gas to establish that the offense is back. That will lead to some big numbers.
- Matchup: Syracuse vs. Clemson
- Date/Time: Saturday, September 20 at 12:00 p.m. ET
- Location: Memorial Stadium
- TV: ESPN
Prop bet #2: Deion Burks Over 63.5 receiving yards
The Oklahoma Sooners have found an offense in 2025 led by Washington State implants John Mateer (quarterback) and Ben Arbuckle (offensive coordinator). The Sooners are averaging 472.7 total yards per game and 6.4 yards per play, and look to make noise in SEC play beginning with a Week 4 date with the Auburn Tigers.
This doesn’t qualify as an easy matchup, but Auburn’s secondary has been forgiving in the early part of the schedule. The Tigers rank 100th in EPA per pass allowed, primarily due to surrendering a high frequency of big plays (123rd in passing explosiveness). They check in at 122nd in PFF’s coverage grade, so Mateer and this Sooners offense should continue to thrive.
Burks leads the way in the receiving room with 17 receptions (on 24 targets) for 225 yards and two scores. He proved to be the go-to target when his team needed him most, going for 101 yards and a score on 12 targets against Michigan, which was the Sooners’ biggest test of the year to date. Look for him to be heavily involved once again.
- Matchup: Auburn vs. Oklahoma
- Date/Time: Saturday, September 20 at 3:30 p.m. ET
- Location: Memorial Stadium
- TV: ABC
Prop bet #3: Que'Sean Brown Over 48.5 receiving yards
The Duke Blue Devils have been hucking the pigskin around the yard with their prized quarterback from the portal, Darian Mensah. He ranks third nationally in passing yards per game (345.3) for an offensive attack that has the fifth-highest passing rate.
Why so much passing? Duke has been unable to run the ball with any consistency (107th in EPA per rush), and the defense has been so poor (114th in EPA per play allowed) that the offense has been forced to play catch-up. Until given a strong reason to think otherwise, we should expect a similar game plan against a quality NC State Wolfpack offense.
With a total of 58.5 at FanDuel, this game is expected to be a shootout. One can see why, as both offenses have been clicking while both defenses have been faltering. One player who should benefit is Duke slot receiver Que’Sean Brown, who has 13 receptions (on 21 targets) for 191 yards and is poised for a productive season.
Mensah should be able to attack an unproven NC State secondary that's starting two redshirt freshmen at safety. Brown has gone for 50+ receiving yards in five of his last seven games and is only improving as a talented sophomore with a big role in this passing attack.
- Matchup: NC State vs. Duke
- Date/Time: Saturday, September 20 at 4:00 p.m. ET
- Location: Wallace Wade Stadium
- TV: ESPN2
Odds are correct at the time of publishing and are subject to change.
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