The Clemson Tigers have an uphill battle if they want to claw back into the Top 25, and it all starts with this afternoon's clash with the visiting Syracuse Orange.
My Syracuse vs. Clemson predictions expect the Orange to at least keep things within the massive point spread.
See why Clemson won't win in blowout fashion with my college football picks on Saturday, September 20.
Syracuse vs Clemson prediction
Syracuse vs Clemson best bet: Syracuse +16.5 (-105)
The Syracuse Orange isn’t the same team it was when the Orange went 10-3 last year. Kyle McCord immediately made the program viable at a Top 25 level, and while Steve Angeli is filling in admirably.
He leads the nation with 1,072 yards passing, and the Orange haven’t looked nearly as potent on offense, while struggling on defense; even the FCS Colgate Raiders put up 24 points against Syracuse last week.
But the Orange haven’t looked awful, and the line in this game seems to be based more on reputation than reality. The Clemson Tigers are 1-2 on the year, and their only win was an 11-point victory over Troy.
The Tigers have yet to cover in any of their three games this season. Cade Klubnik is only completing 59.1% of his passes, and Clemson is averaging 5.5 yards per play, one of the lowest marks in the FBS.
That’s not the profile of a team that will beat a conference rival by three scores. And for what it’s worth, we’ve seen the Orange play Clemson tight over the past decade, often as a significant underdog.
The Tigers will win this one, but I’m taking Syracuse to cover the number.
Syracuse vs Clemson same-game parlay
While Clemson has yet to cover in any of its three games this year, it has also hit the Under three times in a row, and I expect both trends to continue. But the Tigers will find success against a shaky Syracuse run defense, so I’m taking Adam Randall to hit the Over on his yardage total.
Syracuse vs Clemson SGP
- Syracuse +16.5
- Under 54.5
- Adam Randall Over 90.5
Our deep-ball SGP: Willy Willis!
- The Orange will get on the board at some point in this game, and I like Yasin Willis to be the one to find the endzone on the ground.
Syracuse vs Clemson SGP
- Syracuse +16.5
- Under 54.5
- Adam Randall Over 90.5 rushing yards
- Yasin Willis anytime touchdown scorer
Syracuse vs Clemson game predictions
Syracuse vs Clemson moneyline prediction
Clemson (-850): It’s not an exciting pick, but Clemson just has too much talent to see them ever coughing up this game at home to the Orange.
Syracuse vs. Clemson Spread Prediction
Syracuse +16.5 (-105): This number is far too significant for a Clemson team that struggled to put away the Troy Trojans against a Syracuse squad that stayed within three scores of the Tennessee Volunteers.
Syracuse vs Clemson Over/Under prediction
Under 54.5 (-112): Clemson’s defense has played well, and the Tigers will likely focus on their running game against Syracuse, which will lower the number of possessions and keep the score down.
Syracuse vs Clemson odds
- Spread: Syracuse +17.5 (-110) | Clemson -17.5 (-110)
- Moneyline: Syracuse +525 | Clemson -750
- Over/Under: Over 54.5 (-105) | Under 54.5 (-115)
Syracuse vs Clemson trend to know
Syracuse is 5-2 ATS in its last seven meetings with Clemson. Find more college football betting trends for Syracuse vs Clemson.
How to watch Syracuse vs Clemson
| Location | Memorial Stadium, Clemson, SC |
| Date | Saturday, September 20, 2025 |
| Kickoff | 12:00 p.m. ET |
| TV | ESPN |
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Odds are correct at the time of publishing and are subject to change.
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