The Oregon Ducks travel to University Park for a showdown with the Penn State Nittany Lions under the bright lights of Beaver Stadium.
With plenty at stake, this game promises to be one of the better games of the Saturday night slate.
Before you go ahead and lock in your Oregon vs. Penn State predictions, check out what our experts have to say as they bring you their favorite college football picks for September 27.
Oregon vs Penn State Week 5 predictions
- Penn State -3.5 (-110 at FanDuel)
- Under 53.5 (-110 at FanDuel)
- Kaytron Allen Over 68.5 rushing yards (-114 at FanDuel)
- Kaytron Allen anytime TD (-125 at FanDuel)
Oregon vs Penn State best bets
Penn State -3.5 (Odds at FanDuel)
Penn State obviously has options beyond Allen. Nicholas Singleton has scored five touchdowns this season.
Combining that duo should steady the Nittany Lions for the biggest win of the James Franklin Era. And as Penn State forces Oregon away from the pass, it will simply be funneling the Ducks into one of the best defensive fronts in the country, creating a needed edge on both sides of the ball.
/ Under 53.5 (-110 at FanDuel)
Penn State forces opponents to run the ball, mostly by limiting successes on dropbacks, No. 19 in the country in defensive passing success rate, per cfb-graphs.com. But the Nittany Lions are even better defensively against the run, which also happens to be the lesser half of Oregon’s offense.
If Penn State finds an early lead, then the Ducks will be in trouble, the Nittany Lions’ elite defensive line able to pin its ears back and chase quarterback Dante Moore. Do that a time or two, and this game could be out of hand.
That is not an impossible game state. Maybe not likely, but not impossible.
It is, effectively, how Penn State has held its three opponents thus far to no touchdowns in the first 59 minutes of each game. Such a garbage-time touchdown would not be gifted to Oregon.
Oregon vs Penn State prop pick
Kaytron Allen Over 68.5 rushing yards (-114 at FanDuel)
The Nittany Lions throw often — No. 11 in the country at 10.7% more often than expected — but they do not need to. Penn State ranks No. 3 in the country in EPA per rush. Let’s put that as simply as possible: The Nittany Lions improve their chances of scoring on a drive when they run the ball, often by a lot.
Kaytron Allen has led the way, despite Nicholas Singleton getting more carries. Allen has averaged more than eight yards per carry and cleared this prop in two of three games.
That absurd average can be traced to the opponents, but that skeptical note is countered by recognizing Allen cleared this prop despite all being blowouts. He has yet to be tasked with a heavy workload. When that occurs, he should still reach 70+ yards.
Oregon vs Penn State TD pick
Kaytron Allen anytime TD (-125 at FanDuel)
Allen splits carries with fellow senior Nicholas Singleton, who has actually gotten a few more carries and five touchdowns so far this season. But there’s plenty of touches for both in this offense, and given how productive Allen has been on a per-carry basis, I expect him to maintain and perhaps even increase his usage against more competitive opponents.
That starts Saturday against the Oregon Ducks.
Oregon has shut down opposing passing games, holding quarterbacks to an 85.4 rating — the fourth-best mark of any defense in the nation this year. However, the Ducks have been closer to mediocre against the run, with opponents grinding out a decent 3.3 yards per rush.
Allen has shown the ability to break off big plays, and Oregon has yet to play an offense with anywhere near the talent or level of line play of Penn State. While both Nittany Lion running backs should do work against the Ducks, Allen is the better bet to score.
Oregon vs Penn State odds
Oregon vs Penn State game info
| Location: | West Shore Home Field at Beaver Stadium, University Park, PA |
| Date: | Saturday, September 27, 2025 |
| Kickoff: | 7:30 p.m. ET |
| TV: | ABC |
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