The Oklahoma Sooners aim to get back on track as they head to Columbia for an SEC clash with the South Carolina Gamecocks.
South Carolina’s offense has stumbled all season, and my Oklahoma vs. South Carolina predictions expect those struggles to continue against a stout Sooners defense.
Read on for my college football picks for Saturday, October 18.
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Oklahoma vs South Carolina prediction
Oklahoma vs South Carolina best bet: South Carolina team total Under 17.5 (-112)
The South Carolina Gamecocks' offensive issues run deep, and the Oklahoma Sooners' defense is built to expose every one of them.
The Gamecocks allow 3.6 sacks per game and rank near the bottom of the SEC in total offense at just 22.3 points per contest.
Quarterback LaNorris Sellers has shown flashes, but constant pressure and a shaky offensive line have stunted his development.
Now he faces an Oklahoma defense ranked second in the SEC in sacks (4.2 per game) and allows only 25% conversions on third down.
The Sooners allow just 144 passing yards and 78 rushing yards per game, suffocating opponents by controlling the gaps and disguising their relentless pressure.
Unless South Carolina can generate points off turnovers or trick plays, sustained drives will be few and far between against this Oklahoma stop unit.
Oklahoma’s defense has allowed more than 18 points only once this season, and it will keep the Gamecocks bottled up all day.
Oklahoma vs South Carolina same-game parlay
In addition to my best bet, Oklahoma wideout Isaiah Sategna III has grabbed more than 53.5 yards worth of passes in three straight.
Sellers has failed to throw for 190 passing yards or more in four of his six games this season.
Oklahoma vs South Carolina SGP
- South Carolina team total Under 17.5
- Isaiah Sategna III Over 53.5 receiving yards
- LaNorris Sellers Under 189.5 passing yards
Our deep-ball SGP: A Mateer of perspective
Sooners quarterback John Mateer has scored at least one touchdown in four of his previous five games. Gamecocks running back Rashul Faison has only rushed for 44 or more yards twice in six games.
Oklahoma vs South Carolina SGP
- South Carolina team total Under 17.5
- Isaiah Sategna III Over 53.5 receiving yards
- LaNorris Sellers Under 189.5 passing yards
- John Mateer anytime touchdown
- Rashul Faison Under 37.5 rushing yards
Oklahoma vs South Carolina game predictions
Oklahoma vs South Carolina moneyline prediction
Oklahoma needs a bounce back, and it should get it behind one of the country's best defenses, facing a lousy Gamecocks offense.
Oklahoma vs South Carolina spread prediction
Mateer and the Sooners' offense were stymied last week by Texas. They should score enough points, and Oklahoma’s defense should shut down South Carolina to cover the spread.
Oklahoma vs South Carolina Over/Under prediction
The Sooners defense is the best unit on the field. It’s why they have cashed the Under in all six games. The other reason is their offensive struggles. South Carolina defends well enough to get enough stops for this SEC clash to end Under the total.
Oklahoma vs South Carolina odds
- Spread: Oklahoma -5.5 (-110) | South Carolina +5.5 (-110)
- Moneyline: Oklahoma -205 | South Carolina +172
- Over/Under: Over 43.5 (-105) | Under 43.5 (-115)
Oklahoma vs South Carolina trend to know
South Carolina has hit the Team Total Under in 4 of their last six games (+1.75 Units / 25% ROI).. Find more college football betting trends for Oklahoma vs South Carolina.
How to watch Oklahoma vs South Carolina
| Location | Williams-Brice Stadium, Columbia, SC |
| Date | Saturday, October 18, 2025 |
| Kickoff | 12:45 p.m. ET |
| TV | SEC Network |
Oklahoma vs South Carolina latest injuries
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Odds are correct at the time of publishing and are subject to change.
Not intended for use in MA.
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