Week 8 of the 2025 college football season has arrived, and it's a good one, with five ranked-on-ranked matchups on the board.
What’s the right side on the moneyline for the top games like Mississippi vs. Georgia, USC vs. Notre Dame, and Tennessee vs. Alabama?
Here are my moneyline plays and college football picks for the biggest games in Week 8.
Week 8 college football moneyline picks
| Matchup | Pick |
|---|---|
 Louisville vs  Miami |
(-560) |
 Nebraska vs  Minnesota |
(-330) |
 LSU vs  Vanderbilt |
(-132) |
 Texas A&M vs  Arkansas |
(+250) |
 Mississippi vs  Georgia |
(-285) |
 Texas Tech vs  Arizona State |
(-315) |
 USC vs  Notre Dame |
(-345) |
 Tennessee vs  Alabama |
(-310) |
 Missouri vs  Auburn |
(+102) |
 Utah vs  BYU |
(-150) |
Lines courtesy of FanDuel as of 10-15.
Expert Week 8 CFB moneyline picks
Louisville vs Miami: Miami (-560)
No. 2 Miami is a deserved favorite at home, ranking Top 15 in success rate on both sides of the ball. Both teams are well rested after a bye and should give a focused effort with no lookahead spots in Week 9. These teams have combined for 326 points in their last four meetings with one another, so expect a crazy game.
Nebraska vs Minnesota: Nebraska (-330)
No. 25 Nebraska is 5-1 and has a forgiving schedule to close out the year, so there's serious opportunity in front of Matt Rhule and the Cornhuskers. They’ve been the superior team on both sides of the ball, and Minnesota’s offense hasn’t shown enough firepower lately (212 ypg in its last two games) to expect an upset.
LSU vs Vanderbilt: Vanderbilt (-132)
No. 17 Vanderbilt has been the much more reliable offensive unit, leading the nation in both success rate and EPA per play while scoring 43.2 ppg. No. 10 LSU has been dormant on that side of the ball (99th in EPA per play) and quarterback Garrett Nussmeier is visibly hobbled, making the Tigers prime candidates to drop a few games now that the SEC schedule is heating up.
Texas A&M vs Arkansas: Arkansas (+250)
Call me crazy if you want, but I consider No. 4 Texas A&M to be on upset alert in Week 8 in Fayetteville. This is the best offense the Aggies have seen since Notre Dame — who scored 40 points and averaged 6.0 yards per play — so Taylen Green and Arkansas’ potent offense (third in success rate) can make things too close for comfort.
Mississippi vs Georgia: Georgia (-285)
Look for No. 9 Georgia to come out on top in a matchup between two Top-10 teams. Despite the rankings, both have looked entirely mortal — but welcome to the parity of 2025. No. 5 Mississippi is a fraudulent Top-5 team, and its defense (64th in success rate) will be the worst unit on the field, routinely getting gashed on the ground (126th in EPA per rush allowed).
Texas Tech vs Arizona State: Texas Tech (-315)
Sam Leavitt returned to practice on Tuesday, but his status is still in doubt. He’ll be hobbled even if he does play, so the Sun Devils will likely struggle against a star-studded defensive front for No. 7 Texas Tech. The metrics heavily support the Red Raiders, who are Top 10 in EPA per play on both sides of the ball, against an ASU team outside the Top 60 for both.
USC vs Notre Dame: Notre Dame (-345)
No. 20 USC has gone on the road twice and struggled both times, falling to Illinois and beating Purdue thanks to a +3 turnover differential and a big man touchdown. The Trojans are 2-5 in conference road games since joining the Big Ten. No. 13 Notre Dame is being priced like the best team in the country, but it’s hard to argue with that given tthis offense is elite and the defense is now performing up to standard.
Tennessee vs Alabama: Alabama (-310)
No. 6 Alabama didn’t have its A-game last week, but still came away with a victory over Missouri. The Crimson Tide have now reeled off five consecutive victories and are arguably the hottest team in the country after three straight marquee wins (Georgia, Vandy, Missouri). Ty Simpson & Co. should find room against a beatable No. 11 Tennessee defense ranking 96th in success rate.
Missouri vs Auburn: Auburn (+102)
Things haven’t been pretty in Auburn, but Hugh Freeze isn’t a dead man yet. Auburn matches up well defensively, thanks to its feisty rush defense that has held opponents to the lowest success rate on the ground. That’s a necessary ingredient against Ahmad Hardy and Missouri (fourth in rushing success rate), and this is a tough spot coming off the Alabama loss and now playing a night game at Jordan-Hare.
Utah vs BYU: Utah (-150)
No. 23 Utah has been tremendously effective on both offense (ninth in success rate) and defense (12th). They face a No. 15 BYU team that hasn’t been as impressive as its 6-0 record would indicate, nearly falling to both Colorado and Arizona.
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