The Syracuse Orange aim to extend their winning streak to four when they host the Duke Blue Devils at the JMA Wireless Dome on Saturday afternoon.
Both teams are far more effective at putting up points than preventing them, which is why I'm backing the Over in my Duke vs. Syracuse predictions.
Read on to see the full analysis of this ACC matchup along with my free college football picks for Saturday, September 27.
Duke vs Syracuse prediction
Duke vs Syracuse best bet: Over 60.5 (-115)
Both the Syracuse Orange and the Duke Blue Devils have taken one approach to winning games this year: outscore opponents to cover up for shaky defenses.
Syracuse is scoring 38.2 ppg while allowing 27.5 ppg in return; Duke has put up 34 ppg, but has seen its opponents respond with an average of 32.2 ppg.
These are the kinds of trends oddsmakers notice too, and they’ve tried to keep up. Yet the Blue Devils have still hit the Over in all four of their games this year, while Syracuse has also made it to the Over in three of their first four contests.
The one potential area of concern is the season-ending injury to Syracuse quarterback Steve Angeli. Hot on the heels of Kyle McCord’s success in the Orange offense last year, Angel has thrown for 1,317 yards and 10 scores before going down against the Clemson Tigers last week.
But backup quarterback Rickie Collins has something of a pedigree as well, serving as a reserve for the LSU Tigers over the past two seasons after being considered a top prospect out of high school.
I don’t expect the Syracuse offense to slow down much with Collins at the helm. Both teams can still score, can’t play much defense, and should hit the Over on Saturday.
Duke vs Syracuse same-game parlay
I think Syracuse is being underrated due to the loss of starting quarterback Steve Angeli.
I’m taking backup QB Rickie Collins to lead the Orange to continued offensive success and get a win for Syracuse.
Duke vs Syracuse SGP
- Over 60.5
- Syracuse moneyline
- Rickie Collins Over 243.5 passing yards
Our deep-ball SGP: All Starts with Collins
Syracuse hasn’t been great in the running game, but Yasin Willis has scored four touchdowns on the ground this year.
If Collins can be productive through the air, Justus Ross-Simmons should add to his total of five scores on the season.
Duke vs Syracuse SGP
- Over 60.5
- Syracuse moneyline
- Rickie Collins Over 243.5 passing yards
- Yasin Willis anytime TD
- Justus Ross-Simmons anytime TD
Duke vs Syracuse game predictions
Duke vs Syracuse moneyline prediction
Syracuse (+155 at FanDuel): Syracuse has every chance to win this game outright even with their starting quarterback out for the rest of the season.
Duke vs Syracuse spread prediction
Syracuse +4.5 (-105 at FanDuel): The Orange have been the more impressive team this year, and are a great value getting points at home against Duke.
Duke vs Syracuse Over/Under prediction
Over 60.5 (-115 at FanDuel): These two offenses (and defenses) have played to big scores all season long, and I don’t see that changing on Saturday.
Duke vs Syracuse odds
- Spread: Duke -4.5 (-115) | Syracuse +4.5 (-105)
- Moneyline: Duke -188 | Syracuse +155
- Over/Under: Over 58.5 (-115) | Under 58.5 (-105)
Duke vs Syracuse trend to know
The Over is 4-0 in Duke’s games in the 2025 season. Find more college football betting trends for Duke vs Syracuse.
How to watch Duke vs Syracuse
| Location | JMA Wireless Dome, Syracuse, NY |
| Date | Saturday, September 27, 2025 |
| Kickoff | 12:00 p.m. ET |
| TV | ACC Network |
Duke vs Syracuse latest injuries
Duke vs Syracuse weather
Monitor gametime conditions with our College football weather info.
Odds are correct at the time of publishing and are subject to change.
Not intended for use in MA.
Affiliate Disclosure: Our team of experts has thoroughly researched and handpicked each product that appears on our website. We may receive compensation if you sign up through our links.
