Colorado vs TCU Prediction, Picks & Odds for October 4 — College Football Week 6

Colorado has yet to play in a true shootout this year, and the Kaidon Salter-led offense is principally to blame. Our NCAAF picks like Josh Hoover to bounce back for TCU, but the Buffs' offense will guide the way to an Under.

Eric Rosales - Contributor at Covers.com
Eric Rosales • Betting Analyst
Oct 2, 2025 • 16:07 ET • 4 min read

NCAAF

Match starts: 49 hrs
TCU
64 %
COLO
36 %
EXPERT PICK - TOTAL
u58.5 (-110)
Read Analysis
TCU Horned Frogs NCAAF Josh Hoover
Photo By - Imagn Images. TCU Horned Frogs quarterback Josh Hoover (10) hands the ball off.

Two teams yet to find the win column in Big 12 conference play clash Saturday, October 4 when the Colorado Buffaloes visit the TCU Horned Frogs.

The books have pegged TCU as solid 13.5-point home favorites in the college football odds based on some solid offensive performances. My Colorado vs. TCU predictions believe the Buffaloes' offense will be unable to run with them, paving the way to an Under.

Check out the rest of my free college football picks below.

Colorado vs TCU prediction

Colorado vs TCU best bet: Under 58.5 (-110)

If you’ve been keeping up with the Colorado Buffaloes, you know scoring is coming at a premium in their games. They’ve yet to exceed this 58.5-point total in 2025.

Colorado is 14th in scoring in the Big 12, averaging just 25.8 points per game. Things looked promising last time out against BYU, as the Buffaloes built a 14-0 lead, but they were outscored 24-7 the rest of the way.

Deion Sanders seems to have Kaidon Salter as his top QB option over Ryan Staub, but it was a rough outing for Salter against BYU, tossing for 119 yards with one TD and one interception.

The TCU Horned Frogs are fifth in the Big 12 in scoring, pumping out 37.3 points per game, but they were shut down when last seen. TCU blew a 17-point lead in an eventual 27-24 loss to Arizona State, their lowest scoring output of the season.

Injuries are a factor for the Horned Frogs right now. Rushing leader Kevorian Barnes could be back after missing two games with a lower body injury, while leading receiver Eric McAlister is dealing with a hamstring injury. Even if they do play, they could be at less than 100%.

Neither team has an exceptional defense, but they are both decent. TCU is averaging 21.5 ppg against, while Colorado is at 22.8 ppg.

It will be tight, but I expect this one to slide Under the total.

Colorado vs TCU same-game parlay

Josh Hoover had thrown for 11 majors through the first three games, including a season-high five against SMU before getting blanked against ASU.

It’s definitely a bounce-back opportunity for the junior quarterback, who has shown the ability to come back strong. Last year, he was held to no TD passes only twice. Hoover followed up with a three-TD effort against Texas Tech, and a four-TD day against Louisiana in the New Mexico Bowl.

Salter has been inconsistent passing the ball, but his running game has been solid of late. He’s topped his 47.5-yard rush line in two straight games, and faces a TCU rush defense that’s just middle of the pack, allowing 132 yards per game.

Colorado vs TCU 3-leg SGP

  • Under 58.5
  • Josh Hoover Over 2.5 passing TDs
  • Kaidon Salter Over 47.5 rushing yards

Our deep-ball SGP: Backing Battle, Williams

TCU’s Trent Battle leads the team with three rushing TDs on the season, and he’s spread them out, with one score in three of the Horned Frogs’ four games. Colorado is tied for the second-most rushing TDs allowed in the Big 12 with seven.

We’ll target Colorado’s Joseph Williams to find the end zone as well. Williams leads the team in catches and yards, and is tied with Sincere Brown with a team-leading two TD receptions.

His two-TD run was snapped against BYU, but he’s in good shape to start a new run against TCU.

Colorado vs TCU 5-leg SGP

  • Under 58.5
  • Josh Hoover Over 2.5 passing TDs
  • Kaidon Salter Over 47.5 rushing yards
  • Trent Battle anytime TD
  • Joseph Williams anytime TD

Colorado vs TCU odds

  • Spread: Colorado +13.5 | TCU -13.5
  • Moneyline: Colorado +410 | TCU -550
  • Over/Under: Over 58.5 | Under 58.5

Colorado vs TCU trend to know

The Horned Frogs are 2-1-1 against the spread this season. Find more college football betting trends for Colorado vs TCU.

How to watch Colorado vs TCU

Location Amon G. Carter Stadium, Fort Worth, TX
Date Saturday, October 4, 2025
Kickoff 6:30 p.m. ET
TV FOX

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Odds are correct at the time of publishing and are subject to change.
Not intended for use in MA.
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Eric Rosales - Covers
Betting Analyst

Eric has been involved in sports media in many different capacities since graduating from journalism school in 1999, back when getting your own column in a newspaper was still considered a thing. He doubled down and graduated from broadcast journalism school five years later, which led to a move to Toronto and a career with The Sports Network (TSN). From behind-the-scenes production work, he moved into the digital realm, where he had his own hoops column (At the Buzzer), while regularly live streaming and chatting with fans during broadcasts as the character known as LeBlog James. He was also a key contributor to TSN and CTV’s Olympic programming during the 2012 London Games.

Eric eventually found his way into the sports betting field in 2016 and has been a mainstay ever since. He was tagged on Twitter as a Top 10 NBA sharp during the 2021 season and has been interviewed about basketball and his handicapping process on shows from Vancouver to India. Eric is now a jack-of-all-sports at Covers, where his predictions span the alphabet soup: NFL, NBA, MLB, NHL, F1, WNBA, Euro, and Copa.

When making picks, he focuses on finding value first and foremost, and ensuring readers have all the information they need to make an informed choice.

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