College Football AI Predictions Week 2: ATS Picks & Score Predictions for Every Game

Our college football AI predictions went 21-1 straight up across last week's featured matchups but finished with a 7-15 record against the spread. This week, we're firing up the AI prediction model to generate score predictions for all 86 FBS games in Week 2, including the biggest matchups of the week to complement our Week 2 moneyline picks.

Each score projection is generated based on the matchup itself before checking the best prediction market apps to derive ATS and Over/Under picks from the available lines. We're tracking the top matchups first; scroll to the bottom for complete AI picks and score predictions.

Featured college football AI picks for Week 2

The following college football AI picks include our featured matchups as determined by our Covers experts, which include most top-25 matchups and key rivalries for Week 2.

2026 featured picks record: SU 27-3 | ATS 13-17 | O/U 14-16

Matchup	ATS pick	O/U pick	Score prediction
No. 1 Ohio State at No. 4 Texas	+2.5	O49.5	Texas 26-25
Western Kentucky at No. 2 Georgia	+41.5	O55.5	Georgia 52-11
Rice at No. 3 Notre Dame	-44.5	O55.5	Notre Dame 51-5
Howard at No. 5 Indiana	-57.5	U65.5	Indiana 64-0
No. 6 Oregon at Oklahoma State	+23.5	U58.5	Oregon 36-16
Florida A&M at No. 7 Miami	-57.5	U63.5	Miami 62-0
Louisiana Tech at No. 8 LSU	+35.5	O55.5	LSU 46-15
Charlotte at No. 9 Ole Miss	+46.5	O61.5	Ole Miss 58-13
Arizona State at No. 10 Texas A&M	-14.5	O50.5	Texas A&M 38-21
No. 11 Oklahoma at Michigan	-5.5	U43.5	Oklahoma 25-17
No. 12 Alabama at Kentucky	+10.5	U49.5	Alabama 28-18
No. 13 Texas Tech at Oregon State	+27.5	U53.5	Texas Tech 33-14
Louisiana at No. 14 USC	+30.5	O59.5	USC 45-15
Arizona at No. 15 BYU	-7.5	O46.5	BYU 31-22
No. 16 Penn State at Temple	+24.5	O49.5	Penn State 39-16
UC Davis at No. 17 SMU	-24.5	U58.5	SMU 41-13
No. 18 Tennessee at Georgia Tech	+13.5	O55.5	Tennessee 33-23
Utah State at No. 19 Washington	-27.5	U55.5	Washington 39-10
Arkansas at No. 20 Utah	-13.5	O55.5	Utah 44-24
Iowa State at No. 21 Iowa	-13.5	O40.5	Iowa 31-11
No. 23 Missouri at Kansas	+5.5	O50.5	Missouri 30-28
Rutgers at Boston College	-3.5	O54.5	Boston College 33-25

Lines courtesy of Kalshi and subject to change. Final ATS and O/U selections are graded against the exact line at time of publish.

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College football Week 2 AI predictions

Ohio State vs. Texas AI prediction

Ohio State and Texas combined to outscore their opening opponents 115-10, setting up the biggest matchup of Week 2. The forecast gives Texas a narrow home win, with little separating the two offenses. A one-point margin leaves Ohio State inside the 2.5-point spread, while the projected 51 points put the total just Over 49.5.

Score prediction: Texas 26, Ohio State 25

Western Kentucky vs. Georgia AI prediction

Georgia opened with a 63-3 win over Tennessee State, and another comfortable afternoon is the expectation against Western Kentucky. The Bulldogs are projected to reach 50 points again, but a 41-point winning margin leaves the Hilltoppers barely inside the enormous spread. Western Kentucky's projected contribution also helps push this game Over the total.

Score prediction: Georgia 52, Western Kentucky 11

Rice vs. Notre Dame AI prediction

Notre Dame handled Wisconsin 41-13 and now returns home for a matchup the forecast expects it to control on both sides. Rice is projected to struggle to sustain scoring, while the Irish reach 50 points. That produces a Notre Dame cover, although the Over rests on a slim half-point difference between the projected total and the market line.

Score prediction: Notre Dame 51, Rice 5

Howard vs. Indiana AI prediction

Indiana scored 52 points against North Texas, and the forecast expects even more separation against Howard. The Hoosiers are projected to carry nearly all of the scoring in a lopsided home win. That puts Indiana on the ATS side of a 57.5-point spread, while Howard's projected shutout keeps the combined score below 65.5.

Score prediction: Indiana 64, Howard 0

Oregon vs. Oklahoma State AI prediction

Oregon survived a 34-27 opener against Boise State, and the forecast expects a more comfortable result on the road at Oklahoma State. The Ducks are projected to build a three-touchdown advantage, with the Cowboys doing enough offensively to stay within the number. A 52-point combined score also leaves room below the 58.5 total.

Score prediction: Oregon 36, Oklahoma State 16

Florida A&M vs. Miami AI prediction

Miami opened with a 45-6 win at Stanford, and the forecast expects the Hurricanes to overwhelm Florida A&M in their home opener. Miami is projected to clear 60 points while holding the Rattlers scoreless. That lands above the 57.5-point spread, but the lack of scoring from Florida A&M keeps the projected total just below 63.5.

Score prediction: Miami 62, Florida A&M 0

Louisiana Tech vs. LSU AI prediction

LSU scored 51 points against Clemson, and the forecast again expects the Tigers to do most of the scoring against Louisiana Tech. The Bulldogs' projected 15 points matter for both markets: they keep Louisiana Tech within a 35.5-point spread and lift the combined score to 61. LSU is still projected to win by more than four touchdowns.

Score prediction: LSU 46, Louisiana Tech 15

Charlotte vs. Ole Miss AI prediction

Ole Miss needed 41 points to get past Louisville, and the forecast has the Rebels putting up an even bigger number against Charlotte. The projected 45-point margin still leaves the 49ers just inside a 46.5-point spread. Charlotte contributing two scores would also help push this matchup comfortably Over the 61.5 total.

Score prediction: Ole Miss 58, Charlotte 13

Arizona State vs. Texas A&M AI prediction

Texas A&M opened with a 50-0 win over Missouri State, but Arizona State is projected to offer considerably more resistance. The forecast still gives the Aggies enough offense at home to win by 17, clearing a 14.5-point spread. With the Sun Devils contributing three touchdowns, the combined score also lands well above the total.

Score prediction: Texas A&M 38, Arizona State 21

Oklahoma vs. Michigan AI prediction

Oklahoma beat UTEP 51-0 while Michigan needed a late touchdown to escape Western Michigan 13-12. The forecast expects the Wolverines to have another difficult afternoon offensively, even at home. Oklahoma's projected eight-point win clears the 5.5-point spread, and a combined 42 points makes the Under the narrow total pick.

Score prediction: Oklahoma 25, Michigan 17

Alabama vs. Kentucky AI prediction

Alabama and Kentucky both scored at least 45 points in their openers, but this conference matchup projects much lower. The forecast gives Alabama the road win while holding both offenses below their Week 1 output. A 10-point margin leaves Kentucky just inside the 10.5-point spread, with the combined score falling Under 49.5.

Score prediction: Alabama 28, Kentucky 18

Texas Tech vs. Oregon State AI prediction

Texas Tech opened with a 33-10 win over Abilene Christian, and the forecast keeps the Red Raiders at 33 points for this road trip. Oregon State is projected to have trouble keeping pace, but a 19-point defeat would comfortably cover the 27.5-point spread. The Beavers' limited scoring also makes the Under the total pick.

Score prediction: Texas Tech 33, Oregon State 14

Louisiana vs. USC AI prediction

USC shut out Fresno State 39-0, and the forecast expects another decisive home win against Louisiana. The Trojans are projected to reach 45 points, with the Ragin' Cajuns contributing enough to make both market decisions close. Louisiana gets the ATS pick by half a point, and the projected 60-point total barely clears 59.5.

Score prediction: USC 45, Louisiana 15

Arizona vs. BYU AI prediction

BYU and Arizona both cruised through their openers, but their conference matchup projects much closer. The forecast gives BYU the advantage at home, with the Cougars reaching 31 points and winning by nine. That is enough to cover 7.5, while Arizona's projected 22 points help lift the combined score above the 46.5 total.

Score prediction: BYU 31, Arizona 22

Penn State vs. Temple AI prediction

Penn State opened with a 45-0 win over Marshall, and the forecast expects another convincing result against Temple. The Owls are projected to contribute more offense than Marshall did, keeping the final margin just below the 24.5-point spread. Penn State's scoring does most of the work toward a combined 55 points and an Over selection.

Score prediction: Penn State 39, Temple 16

UC Davis vs. SMU AI prediction

SMU comes off a 27-24 Monday win at Florida State and now has a shorter turnaround before hosting UC Davis. The forecast expects the Mustangs to pull away at home, reaching 41 points while limiting the Aggies to 13. That produces a four-touchdown margin, enough for an SMU cover, with the total remaining Under 58.5.

Score prediction: SMU 41, UC Davis 13

Tennessee vs. Georgia Tech AI prediction

Tennessee scored 56 points in its opener while Georgia Tech lost a 14-13 game to Colorado. The forecast expects the Yellow Jackets to produce more offense this week, keeping the margin to 10 against the visiting Volunteers. That puts Georgia Tech inside the 13.5-point spread, although the Over is only a half-point lean.

Score prediction: Tennessee 33, Georgia Tech 23

Utah State vs. Washington AI prediction

Washington held Washington State to 10 points in a 24-10 opening win, and the forecast projects the same defensive allowance against Utah State. More scoring from the Huskies creates a 29-point winning margin, enough to clear 27.5. Utah State's projected struggles on offense also leave the combined score well below the total.

Score prediction: Washington 39, Utah State 10

Arkansas vs. Utah AI prediction

Utah scored 66 points against Idaho, and the forecast expects the Utes to remain productive at home against Arkansas. The Razorbacks are projected to contribute 24 points, but Utah's offense still creates a 20-point winning margin. That clears the 13.5-point spread, while scoring from both teams sends this matchup Over 55.5.

Score prediction: Utah 44, Arkansas 24

Iowa State vs. Iowa AI prediction

Iowa opened with a 40-0 win over Northern Illinois, and the forecast expects its defense to make another strong showing in the Cy-Hawk game. Iowa State is projected to manage just 11 points, leaving the Hawkeyes with a comfortable cover. Iowa reaching 31 also pushes the combined score slightly above the low 40.5 total.

Score prediction: Iowa 31, Iowa State 11

Missouri vs. Kansas AI prediction

Missouri and Kansas both cleared 50 points in their openers, but the Border War projects as a much tighter contest. The forecast gives Missouri a two-point road win, leaving Kansas inside the 5.5-point spread. Both offenses are expected to reach the high 20s, which puts the combined score well Over the 50.5 total.

Score prediction: Missouri 30, Kansas 28

Rutgers vs. Boston College AI prediction

Rutgers lost 37-21 to UMass, while Boston College fell 34-15 at Cincinnati. The forecast gives the Eagles the better response at home, with their offense improving enough to reach 33 points. Rutgers is projected to keep scoring as well, but an eight-point margin supports Boston College against the spread and the Over on 54.5.

Score prediction: Boston College 33, Rutgers 25

College football AI picks for every Week 2 game

We are tracking AI score predictions, ATS picks, Over/Under picks, kickoff times, and TV channels for all 86 Week 2 games involving at least one FBS team. Games are listed chronologically by kickoff.

2026 record for every game: SU 90-9 | ATS 47-52 | O/U 53-46

Date / time	Matchup	ATS pick	O/U pick	Score prediction
Thu., Sept. 10 8:00 p.m. ET ACC Network	FAMU at MIA	-57.5	U63.5	Miami 62-0
Fri., Sept. 11 7:00 p.m. ET ESPNU	RICH at NCSU	-30.5	O49.5	NC State 45-12
Fri., Sept. 11 7:00 p.m. ET ACC Network	VILL at LOU	VILL +35.5	O56.5	Louisville 40-17
Fri., Sept. 11 7:00 p.m. ET ACCNX	NORF at UVA	NORF +45.5	U55.5	Virginia 47-3
Fri., Sept. 11 7:30 p.m. ET ESPN2	RUTG at BC	-3.5	O54.5	Boston College 33-25
Fri., Sept. 11 8:00 p.m. ET FOX	MIZ at KU	+5.5	O50.5	Missouri 30-28
Sat., Sept. 12 12:00 p.m. ET BTN	HOW at IU	-57.5	U65.5	Indiana 64-0
Sat., Sept. 12 12:00 p.m. ET FOX	OU at MICH	-5.5	U43.5	Oklahoma 25-17
Sat., Sept. 12 12:00 p.m. ET ESPN / Disney+	ORE at OKST	+23.5	U58.5	Oregon 36-16
Sat., Sept. 12 12:00 p.m. ET ESPN2	PSU at TEM	+24.5	O49.5	Penn State 39-16
Sat., Sept. 12 12:00 p.m. ET FS1	WAKE at PUR	-2.5	O49.5	Wake Forest 27-24
Sat., Sept. 12 12:00 p.m. ET ACC Network	ETSU at UNC	ETSU +35.5	U54.5	North Carolina 37-10
Sat., Sept. 12 12:00 p.m. ET CW	ODU at VT	-20.5	O49.5	Virginia Tech 37-14
Sat., Sept. 12 12:00 p.m. ET ABC	ASU at TA&M	-14.5	O50.5	Texas A&M 38-21
Sat., Sept. 12 12:00 p.m. ET TNT	WSU at KSU	-17.5	O49.5	Kansas State 36-16
Sat., Sept. 12 12:00 p.m. ET ESPNU	APP at ECU	+7.5	O56.5	East Carolina 30-29
Sat., Sept. 12 12:00 p.m. ET CBSSN	USF at ARMY	-3.5	O47.5	Army 30-22
Sat., Sept. 12 12:00 p.m. ET ESPN+	WOF at KENT	WOF +11.5	O46.5	Kent State 30-24
Sat., Sept. 12 12:45 p.m. ET SEC Network	WKU at UGA	+41.5	O55.5	Georgia 52-11
Sat., Sept. 12 1:00 p.m. ET ESPN+	UTM at WVU	UTM +41.5	U56.5	West Virginia 38-15
Sat., Sept. 12 1:00 p.m. ET ESPN+	COLG at CMU	COLG +23.5	O33.5	Central Michigan 32-15
Sat., Sept. 12 1:00 p.m. ET ESPN+	HC at M-OH	HC +30.5	O49.5	Miami (OH) 36-15
Sat., Sept. 12 2:00 p.m. ET ESPN+	STBK at BALL	STBK +14.5	U57.5	Ball State 30-23
Sat., Sept. 12 3:30 p.m. ET FS1	DUKE at ILL	+5.5	O51.5	Illinois 29-25
Sat., Sept. 12 3:30 p.m. ET CBSSN	MD at CONN	+11.5	O52.5	Maryland 32-23
Sat., Sept. 12 3:30 p.m. ET BTN	EMU at MSU	-17.5	O49.5	Michigan State 38-15
Sat., Sept. 12 3:30 p.m. ET CBS	MSST at MINN	-1.5	O54.5	Minnesota 32-29
Sat., Sept. 12 3:30 p.m. ET BTN	USU at WASH	-27.5	U55.5	Washington 39-10
Sat., Sept. 12 3:30 p.m. ET ACC Network	CAL at SYR	-3.5	O56.5	Syracuse 36-24
Sat., Sept. 12 3:30 p.m. ET ESPN2	UCF at PITT	-7.5	O56.5	Pittsburgh 37-27
Sat., Sept. 12 3:30 p.m. ET FOX	ARIZ at BYU	-7.5	O46.5	BYU 31-22
Sat., Sept. 12 3:30 p.m. ET ESPN+	WEB at COLO	WEB +34.5	U54.5	Colorado 38-8
Sat., Sept. 12 3:30 p.m. ET ABC / Disney+	ALA at UK	+10.5	U49.5	Alabama 28-18
Sat., Sept. 12 3:30 p.m. ET CW	UTSA at TXST	+1.5	O66.5	UTSA 41-36
Sat., Sept. 12 3:30 p.m. ET ESPN+	ULM at UAB	-10.5	O55.5	UAB 42-22
Sat., Sept. 12 3:30 p.m. ET ESPN+	RMU at AKR	RMU +27.5	O41.5	Akron 36-14
Sat., Sept. 12 3:30 p.m. ET ESPN+	SHU at MASS	SHU +24.5	U53.5	UMass 36-14
Sat., Sept. 12 3:30 p.m. ET ESPN+	CCSU at TOL	CCSU +33.5	U55.5	Toledo 36-11
Sat., Sept. 12 3:30 p.m. ET ESPN+	WAG at JMU	WAG +45.5	U54.5	James Madison 42-6
Sat., Sept. 12 3:30 p.m. ET NBC	RICE at ND	-44.5	O55.5	Notre Dame 51-5
Sat., Sept. 12 3:45 p.m. ET ESPNU	UNLV at UNT	-3.5	O57.5	UNLV 37-23
Sat., Sept. 12 4:00 p.m. ET ACCNX	UCD at SMU	-24.5	U58.5	SMU 41-13
Sat., Sept. 12 4:00 p.m. ET ESPN+	ALST at TROY	ALST +23.5	U52.5	Troy 31-20
Sat., Sept. 12 4:00 p.m. ET MW+	MERC at UNM	-41.5	O52.5	New Mexico 53-7
Sat., Sept. 12 4:00 p.m. ET MW+	UNCO at WYO	UNCO +23.5	U48.5	Wyoming 31-15
Sat., Sept. 12 4:15 p.m. ET SEC Network	DEL at VAN	+20.5	O54.5	Vanderbilt 38-18
Sat., Sept. 12 5:30 p.m. ET SECN+	CAM at FLA	CAM +49.5	U66.5	Florida 54-5
Sat., Sept. 12 6:00 p.m. ET ESPN+	JVST at OHIO	+2.5	O50.5	Jacksonville State 31-21
Sat., Sept. 12 6:00 p.m. ET ESPN+	BUFF at FIU	+10.5	U47.5	FIU 24-15
Sat., Sept. 12 6:00 p.m. ET ESPN+	GWEB at LIB	-10.5	U54.5	Liberty 39-13
Sat., Sept. 12 6:00 p.m. ET USA Net	MEM at BOIS	-9.5	O55.5	Boise State 37-25
Sat., Sept. 12 6:30 p.m. ET ESPN+	MONM at WMU	-14.5	U56.5	Western Michigan 33-10
Sat., Sept. 12 7:00 p.m. ET FS1	BGSU at NEB	+30.5	U51.5	Nebraska 38-10
Sat., Sept. 12 7:00 p.m. ET ESPN	TENN at GT	+13.5	O55.5	Tennessee 33-23
Sat., Sept. 12 7:00 p.m. ET SECN+	TOW at SC	-42.5	O55.5	South Carolina 50-6
Sat., Sept. 12 7:00 p.m. ET ESPN+	WCU at CIN	WCU +36.5	U60.5	Cincinnati 42-12
Sat., Sept. 12 7:00 p.m. ET ESPN+	SOU at HOU	-50.5	O60.5	Houston 56-5
Sat., Sept. 12 7:00 p.m. ET MW+	ILST at NIU	ILST -3.5	O47.5	Illinois State 27-21
Sat., Sept. 12 7:00 p.m. ET ESPN+	WES at ARST	Not listed	Not listed	Arkansas State 42-15
Sat., Sept. 12 7:00 p.m. ET ESPN+	GAST at KENN	-9.5	O54.5	Kennesaw State 39-20
Sat., Sept. 12 7:00 p.m. ET ESPN+	MTSU at MRSH	+13.5	O56.5	Marshall 37-24
Sat., Sept. 12 7:00 p.m. ET ESPN+	USA at TULN	+9.5	U50.5	Tulane 26-20
Sat., Sept. 12 7:00 p.m. ET ESPN+	LIN at MOST	LIN +20.5	O36.5	Missouri State 30-22
Sat., Sept. 12 7:00 p.m. ET ESPN+	TLSA at SHSU	-13.5	U51.5	Tulsa 34-16
Sat., Sept. 12 7:00 p.m. ET CBSSN	SUU at CSU	SUU +20.5	U57.5	Colorado State 34-15
Sat., Sept. 12 7:15 p.m. ET BTN	SDSU at UCLA	-11.5	O55.5	UCLA 37-22
Sat., Sept. 12 7:15 p.m. ET BTN	WIU at WIS	-36.5	U49.5	Wisconsin 42-5
Sat., Sept. 12 7:30 p.m. ET NBC	ISU at IOWA	-13.5	O40.5	Iowa 31-11
Sat., Sept. 12 7:30 p.m. ET ABC	OSU at TEX	+2.5	O49.5	Texas 26-25
Sat., Sept. 12 7:30 p.m. ET ACC Network	GASO at CLEM	+20.5	U55.5	Clemson 34-17
Sat., Sept. 12 7:30 p.m. ET ESPNU	NAVY at FAU	-4.5	O58.5	Navy 41-32
Sat., Sept. 12 7:30 p.m. ET CBS	TTU at ORST	+27.5	U53.5	Texas Tech 33-14
Sat., Sept. 12 7:30 p.m. ET ESPN+	FOR at CCU	FOR +33.5	O48.5	Coastal Carolina 41-12
Sat., Sept. 12 7:30 p.m. ET SECN+	LT at LSU	+35.5	O55.5	LSU 46-15
Sat., Sept. 12 7:45 p.m. ET ESPN2	CLT at MISS	+46.5	O61.5	Ole Miss 58-13
Sat., Sept. 12 7:45 p.m. ET SEC Network	USM at AUB	+33.5	U56.5	Auburn 34-12
Sat., Sept. 12 8:00 p.m. ET ESPN+	PV at BAY	PV +38.5	O55.5	Baylor 45-11
Sat., Sept. 12 8:00 p.m. ET ESPN+	GRAM at TCU	-41.5	U55.5	TCU 50-5
Sat., Sept. 12 9:00 p.m. ET MW+	CP at SJSU	CP +20.5	U57.5	San Jose State 33-18
Sat., Sept. 12 9:00 p.m. ET MW+	TXSO at UTEP	TXSO +24.5	U53.5	UTEP 35-16
Sat., Sept. 12 10:00 p.m. ET FS1	NDSU at AFA	+2.5	U47.5	Air Force 23-21
Sat., Sept. 12 10:15 p.m. ET ESPN	ARK at UTAH	-13.5	O55.5	Utah 44-24
Sat., Sept. 12 10:30 p.m. ET CBSSN	SAC at FRES	+17.5	U46.5	Fresno State 29-13
Sat., Sept. 12 10:30 p.m. ET CW	MTST at NEV	+2.5	O50.5	Montana State 26-25
Sat., Sept. 12 11:00 p.m. ET BTN	UL at USC	+30.5	O59.5	USC 45-15
Sun., Sept. 13 12:00 a.m. ET K5 / MW+	NMSU at HAW	-7.5	U49.5	Hawaii 30-19

Kickoff times and TV listings are current as of publication and subject to change. Market lines are also subject to change. Kalshi had not listed a spread or total for West Georgia vs. Arkansas State at the time of the market check.

How our college football AI predictions work

Our college football AI predictions use a custom forecasting process to project a final score for each matchup using preseason team strength, separate offensive and defensive ratings, opponent-adjusted Week 1 results, home-field context, and historical scoring variation.

Each score projection is locked before the final Kalshi market snapshot used for publication. Those projected scores are then compared with the representative spread and total to produce our ATS and Over/Under selections.

We’ll continue updating the process as the season develops and publicly track every published score prediction, ATS pick, and Over/Under selection.

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