Louisville hosts Syracuse in its home finale without star guard Mikel Brown, who is out with a lingering back injury.
My Syracuse vs Louisville predictions and college basketball picks break down why Louisville is well-suited to cover this number on Tuesday, March 3.
Syracuse vs Louisville prediction
Syracuse vs Louisville best bet: Louisville -12.5 (-110)
Mikel Brown is out, but Louisville's offense doesn't need him to exploit Syracuse.
The Cardinals rank in the 97th percentile in attack and kicks, and Syracuse simply doesn’t defend that well enough (0.93 PPP allowed).
In addition, an elite transition offense will get a boost against a Cuse team that allows transition at a 90th-percentile frequency.
On defense, the Cards clamp down on the areas Syracuse relies on, most importantly perimeter cuts — ranking in the 95th percentile nationally in defending such actions.
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Syracuse vs Louisville same-game parlay
With Brown out, Ryan Conwell will be the primary option for Louisville's offense and kicks, especially if it can get him off the ball some.
This total feels falsely inflated. The Cardinals' defense has been poor much of the season, but I’m not sold that a disinterested Syracuse team will score enough to push this total Over.
Syracuse vs Louisville SGP
- Louisville -12.5
- Ryan Conwell Over 20.5 points
- Under 158.5
Our beyond the arc SGP: Deep threat
The Orange have struggled to defend some of the elite 3-point actions that Louisville runs, and Isaac McKneely will get a huge volume of those looks.
Syracuse vs Louisville SGP
- Louisville -12.5
- Ryan Conwell Over 20.5 points
- Under 158.5
- Isaac McKneely Over 2.5 threes
Syracuse vs Louisville odds
- Spread: Syracuse +12.5 | Louisville -12.5
- Moneyline: Syracuse +700 | Louisville -1100
- Over/Under: Over 158.5 | Under 158.5
Syracuse vs Louisville betting trend to know
Louisville has hit the first-half moneyline in its last three games at home (+3.00 Units / 6% ROI). Find more college basketball betting trends for Syracuse vs. Louisville.
How to watch Syracuse vs Louisville
| Location | KFC Yum! Center, Louisville, KY |
| Date | Tuesday, March 3, 2026 |
| Tip-off | 9:00 p.m. ET |
| TV | ACC Network |
Syracuse vs Louisville key injuries
Odds are correct at the time of publishing and are subject to change.
Not intended for use in MA.
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