The injury-plagued Houston Astros have dropped three consecutive games by multiple runs, and five of the last seven overall.
My Mariners vs. Astros predictions expect their struggles to continue in the second game of this AL West matchup.
Let's break down my MLB picks for Tuesday, May 12.
Who will win Mariners vs Astros today: Seattle Mariners (-150)
The Houston Astros have hit righties well this season... but they have not hit them well of late. They're dealing with injuries to key bats like Jeremy Pena, Carlos Correa, and Yainer Diaz — and they're really showing up.
Houston sits 19th in weighted on-base average (wOBA) against right-handed pitching in May, miles below their seasonal rank of third. They've struck out at a league-high 28.6% clip and have also hit grounders at the 11th-highest rate.
That doesn't set them up for success against Bryan Woo, who owns a strong 16% K-BB rate and has not allowed a homer in six of eight starts.
COVERS INTEL: Woo's soft contact rate of 21.6% is the best of his career.
Mariners vs Astros Over/Under pick: Under 8.5 (+100)
The Astros are struggling to score runs. They have plated just two in their last three games and have scored three or fewer in seven of their last eight. Manufacturing offense is extremely challenging with so much firepower missing from the lineup.
Although the Seattle Mariners should have an easier time against Tatsuya Imai and a subpar bullpen, they rank 25th in runs, 26th in average, and All-Star catcher Cal Raleigh doesn't have a hit this month. They're not exactly a dynamic offense likely to put forth a ceiling game.
- ML/RL bets: 16-7, +6.18 units
- Over/Under bets: 10-12-1, -3.11 units
Mariners vs Astros odds
- Moneyline: Mariners -150 | Astros +130
- Run line: Mariners -1.5 (+110) | Astros +1.5 (-130)
- Over/Under: Over 8.5 (-115) | Under 8.5 (-105)
Mariners vs Astros trend
The Seattle Mariners have hit the moneyline in seven of their past 10 away games (+3.05 units, 22% ROI). Find more MLB betting trends for Mariners vs. Astros.
How to watch Mariners vs Astros and game info
| Location | Daikin Park, Houston, TX |
| Date | Tuesday, May 12, 2026 |
| First pitch | 8:10 p.m. ET |
| TV | Mariners.TV, SCHN |
| Mariners starting pitcher | Bryan Woo (2-2, 4.02 ERA) |
| Astros starting pitcher | Tatsuya Imai (1-0, 7.07 ERA) |
Mariners vs Astros latest injuries
Mariners vs Astros weather
Odds are correct at the time of publishing and are subject to change.
Not intended for use in MA.
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