Yankees vs Cardinals Picks and Predictions: St. Louis Continues to Soar

St. Louis is surging out of the All-Star break, winners of five in a row and seven of eight. The Cardinals' form has been so hot that they're the MLB betting favorites against the Yankees — and our picks and predictions agree.

Last Updated: Aug 6, 2022 12:12 PM ET Read Time: 4 min
Paul Goldschmidt St. Louis Cardinals MLB
Photo By - USA TODAY Sports

An interleague series between two of baseball’s bluebloods continues at Busch Stadium on Saturday night as the St. Louis Cardinals host the New York Yankees.

The Cardinals fired the opening salvo on Friday night with a 4-3 victory. Can the Yankees respond against their former teammate in Jordan Montgomery? 

Find out in our free MLB picks and predictions for Yankees vs. Cardinals on Saturday, August 6. 

Yankees vs Cardinals odds

This odds widget represents the best odds available for each betting market from regulated sportsbooks.

The Yankees opened as the consensus favorites at -119 on the road, but bettors have pounded the Cardinals down to favoritism as of Saturday morning. St. Louis went from +110 to -110 or -115 at the majority of sportsbooks. The total has been bet up from its original line of 8.0 to 8.5 just about everywhere.

Use the live odds widget above to track any future line movements right up until first pitch and be sure to check out the full MLB odds before placing your bets.

Yankees vs Cardinals predictions

Picks made on 8/6/2022 at 11:40 a.m. ET.
Click on each pick to jump to the full analysis.

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Yankees vs Cardinals game info

Location: Busch Stadium, St. Louis, MO
Date: Saturday, August 6, 2022
First pitch: 7:15 p.m. ET

Yankees vs Cardinals betting preview

Starting pitchers

Domingo German (1-1, 6.39 ERA): German picked up his first win of the season in his third start, holding the Mariners to two runs over five frames on Monday night. Though he limited the damage, Seattle was still able to generate plenty of traffic on the bases in that tilt, gathering six hits and three walks. German has allowed four homers over just 12 2-3 innings in 2022.

Jordan Montgomery (3-3, 3.69 ERA): After being dealt at the deadline for the injured Harrison Bader in one of the more puzzling trades of the season, Montgomery will try to get revenge against the Yankees in his Cardinals debut. He’ll be hoping for a bit more run support from St. Louis, as New York dropped each of their last six games behind Monty. However, the southpaw has struggled in his last two starts, allowing eight runs over 6 1-3 innings.


Be sure to monitor the gametime conditions with our MLB weather info.

Key injuries

Find our latest MLB injury reports.

Betting trend to know

The Over is 20-8 in the Cardinals’ last 28 games against AL East opponents. Find more MLB betting trends for Yankees vs. Cardinals

Yankees vs Cardinals picks and predictions

Our side and total predictions are based upon our analysis of the line and total in this game. Our best bet is our favorite pick across all markets.

Moneyline analysis

Money has flooded in on the Cardinals on Saturday, and it appears to be well-intentioned.

The Yankees are still the best team in the AL by win percentage (.654), but the second half of the season has not been kind to them so far, as they’re 6-8. That includes Friday night’s heartbreaking loss to St. Louis, in which Clay Holmes was tagged for the deciding two runs in the bottom of the eighth inning. 

Holmes earned the role of closer in-season but has lost his way recently, pitching to a 1.80 WHIP over his last 10 outings. He’s blown three saves while picking up only one in the process. 

Bombers manager Aaron Boone doesn’t just have the ninth inning to worry about in this one. Trouble could start as soon as the first frame with Domingo German on the mound. His 6.39 ERA and 1.82 WHIP through his first three starts are the stuff of nightmares. 

The Cardinals — who have now won five in a row and seven of their last eight — have been running like a well-oiled machine on offense since the All-Star break, plating 5.08 runs per game. Not surprisingly, Paul Goldschmidt and Nolan Arenado have been at the forefront of the attack.

Goldschmidt is batting .325 since the second half of the season began with six homers and 12 RBI. Arenado has a 1.107 OPS. 

They should give freshly acquired starter Jordan Montgomery a comfortable early lead as he faces his former club in this tilt. Montgomery may be able to navigate himself through five or six innings as long as he keeps the ball away from Aaron Judge, who’s batting .404 since the All-Star break with 10 homers and 23 RBI.

Trend bettors should note that the Yankees are 1-5 in their last six interleague road games and 1-7 in their last eight against teams with winning records. Also, the Cardinals have won each of their last six home games and are 19-8 in their last 27 games against starters with a WHIP greater than 1.30. 

Prediction: Cardinals moneyline (-106 at Unibet)

Over/Under analysis

This New York lineup is far too potent to keep off the board entirely. The Yankees should do their part in ensuring that this Saturday evening affair exceeds the total.

The Yankees have averaged an MLB-best 5.33 runs per game in 2022 and are second only to the Los Angeles Dodgers in runs per game on the road (5.45 to 5.29). Judge has obviously been a key contributor, but a few of his Bombers teammates have been helping him out of late.

DJ LeMahieu has been raging-hot over the last week, batting .400 with a pair of four-baggers. Former Cardinal Matt Carpenter has been even better in that span, hitting .412 with a solo dinger. He had two hits in his St. Louis “homecoming” on Friday night.

Even the light-hitting Isiah Kiner-Falefa has upped his game since the All-Star break, authoring a .300 batting average. It’s making up for a lack of early production from Andrew Benintendi, who has only two hits in his first 24 at-bats as a Yankee.

If the Bombers are unable to pierce Montgomery, then they should be able to scratch out some runs against the Redbirds’ bullpen, which is 22nd by ERA in the second half of the season (4.15). 

The trends suggest an Over is in store, as the Yankees are 11-3-1 to the Over in their last 15 games against teams with winning records. The Cards have gone above the total in seven of their last eight interleague games against right-handed starters.

Prediction: Over 8.5 (-110 at WynnBET)

Best bet

As we indicated in our player prop picks for today, Goldschmidt looks like a great bet to grab a run in this one. 

Goldschmidt has kickstarted the month of August by crossing the plate in each of his first four games, driving himself in twice with taters. He’s recorded at least one run in 12 of his last 15 overall.

The red-hot Arenado has just as good a chance as Goldy does to drive him home in this one. It wouldn’t be shocking to see this prop cash as soon as the first inning against German. There’s also a great deal of value in siding with one of the Cards’ most reliable sources of production instead of sweating out an entire team effort against the current World Series co-favorite. 

Pick: Paul Goldschmidt Over 0.5 runs (+118 at Unibet)

MLB parlays

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Use our MLB parlay calculator to create your own parlays and see their potential payouts.

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