MLB Predictions and Moneyline Picks for Saturday, May 23

There is no shortage of action today with 16 games on the MLB schedule.

To help you build your card, we’re breaking down our favorite moneyline locks and value plays for every matchup—headlined by a massive Saturday night showdown on FOX between the Los Angeles Dodgers and the red-hot Milwaukee Brewers.

Read on as I break down all of my top MLB picks for May 23.

MLB moneyline picks for May 23

Matchup	Pick
Cardinals vs Reds	+105
Rays vs Yankees	+119
Astros vs Cubs	+129
Pirates vs Blue Jays	-142
Tigers vs Orioles	-112
Guardians vs Phillies	-183
White Sox vs Giants	+109
Mariners vs Royals	-126
Twins vs Red Sox	-112
Nationals vs Braves	-183
Mets vs Marlins	-107
Cardinals vs Reds	-103
Dodgers vs Brewers	-116
A's vs Padres	-107
Rangers vs Angels	-131
Rockies vs Diamondbacks	-168

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Expert MLB moneyline picks for May 23

Cardinals vs Reds: Cardinals (+105)

Cardinals win probability: 50%

The St. Louis Cardinals head into Cincinnati seeking an NL Central bounce-back series win, and they have the perfect weapon on the mound. Andre Pallante dominates the Reds historically, carrying a 6-4 record, a 2.49 ERA, and 49 strikeouts across 19 career appearances. Take the Cardinals moneyline to cash in Game 1 of the doubleheader.

Rays vs Yankees: Rays (+119)

Rays win probability: 45%

Drew Rasmussen vs. the New York Yankees is a mismatch on paper — the righty is 4-1 with a 1.03 ERA and 51 punchouts in eight career games against New York. Coming off a thrilling comeback win on Friday, the division-leading Rays are primed to keep the foot on the gas behind their dynamic arm.

Astros vs Cubs: Astros (+129)

Astros win probability: 43%

After dropping the series opener to the Astros, the Cubs try to even the score on Saturday. They’ll have to do it against the teeth of Houston's rotation, starting with Kai-Wei Teng (2-3, 2.61 ERA). With Colin Rea taking the mound for Chicago amid a recent rough patch (4.98 ERA), the pitching matchup favors an otherwise banged-up Houston squad.

Pirates vs Blue Jays: Pirates (-142)

Pirates win probability: 57%

The Pittsburgh Pirates send ace Paul Skenes to the mound on Saturday afternoon looking to rebound from a series-opening loss. Facing a Toronto Blue Jays lineup hitting just .248 against righties this season, expect Skenes to control the tempo and help the Bucs bounce back.

Tigers vs Orioles: Orioles (-112)

Orioles win probability: 52%

The Baltimore Orioles have a prime opportunity to pick up a win on Saturday against Framber Valdez. The left-handed starter owns a mediocre 4.17 career ERA in seven outings against the Orioles, making him vulnerable to an O's lineup featuring Sam Huff, who leads the team with a blistering .400 batting average against southpaws this year.

Phillies win probability: 64%

Zack Wheeler is living up to his nickname, wheeling and dealing his way to a 1.99 ERA and a perfect 3-0 record for the Philadelphia Phillies. Up next are the Guardians, whose .222 team batting average against righties is bound to tank even further against Philadelphia's elite right-hander.

White Sox vs Giants: White Sox (+109)

White Sox win probability: 47%

Erick Fedde has a prime opportunity to hand the White Sox a road win today. He faces a San Francisco lineup hitting just .240 against righties with a sluggish .290 OBP. With Chicago boasting a significantly sharper .323 OBP to spark their own offense, backing the White Sox as road underdogs offers great value.

Mariners vs Royals: Mariners (-126)

Mariners win probability: 55%

This matchup features two middle-of-the-pack teams in their respective divisions, but the Seattle Mariners have a massive situational edge on the mound. George Kirby has been a certified cheat code against the Kansas City Royals, boasting a flawless 2-0 record, a 2.08 ERA, and 17 punchouts in four career games. Back the Mariners on the road to shut down the KC offense.

Twins vs Red Sox: Red Sox (-112)

Red Sox win probability: 52%

With Taj Bradley expected to show some rust in his first start back on the mound, the Boston Red Sox are in a prime bounce-back spot. After letting Friday night's game slip away late, the Boston offense should find plenty of success early against the right-hander.

Nationals vs Braves: Braves (-183)

Braves win probability: 64%

The red-hot Atlanta Braves look to continue their dominant run today, and a matchup against Jake Irvin gives them a massive upper hand. Irvin has struggled out of the gate this season with a bloated 5.79 ERA, and his lifetime numbers versus Atlanta — a 2-3 record and 3.98 ERA in eight games — aren't reassuring. Back the Braves moneyline to take care of business at home.

Mets vs Marlins: Marlins (-107)

Marlins win probability: 51%

Max Meyer has been delivering massive value for the Marlins, boasting a spotless record and a sharp 2.85 ERA. This afternoon, Miami looks to add to the Mets' divisional misery. Look for the Marlins to exploit a struggling New York team and cash as a lively home underdog.

Cardinals vs Reds: Reds (-103)

Reds win probability: 50%

Back on the mound against the team that ruined his big-league debut a year ago, Chase Petty is looking for ultimate redemption. With a full season of developmental adjustments under his belt, expect the Cincinnati Reds' prospect to bounce back with a much cleaner start and help salvage a split in today's doubleheader.

Dodgers vs Brewers: Dodgers (-116)

Dodgers win probability: 53%

Roki Sasaki is on the bump for the Los Angeles Dodgers as they look to rebound from a Game 1 loss to the Milwaukee Brewers in this series. His 5.09 ERA is a bit inflated, but his electric strikeout stuff means he can dominate any lineup when he's on. Expect a strong response from L.A. behind their young right-hander.

A's vs Padres: A's (-107)

Padres win probability: 51%

The San Diego Padres are tough at home, but J.T. Ginn gives the Athletics a serious edge to pull off Saturday's upset. The AL West-leading A's have a great weapon on the bump today, as Ginn brings a stellar 2.98 ERA and 44 strikeouts into this matchup. Grab the visitors to steal a big road win.

Rangers vs Angels: Rangers (-131)

Rangers win probability: 56%

Laying it with the Texas Rangers looks like an even sweeter deal on Saturday night thanks to their edge on the bump. Texas hands the ball to Nathan Eovaldi, who has absolutely owned the Los Angeles Angels throughout his career, boasting a 7-3 record, a 3.04 ERA, and 77 punchouts in 16 career outings against them.

Diamondbacks win probability: 62%

Zac Gallen has been an absolute cash machine when facing the Colorado Rockies. Over 18 career outings against the Rockies, the righty has pitched his way to a 9-1 record, a 3.41 ERA, and 121 strikeouts. Lock in the Arizona Diamondbacks tonight as Gallen looks to maintain his historical mastery over his division rivals.

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