MLB Predictions and Moneyline Picks for Monday, Sept. 14

Colby Marchio - Contributor at Covers.com
Colby Marchio • Betting Analyst 7+ years betting experience
Updated: Sep 14, 2026 , 11:40 AM ET • 4 min read

Monday's MLB moneyline predictions feature a few underdogs with some bite, while backing a ton of juicy favorites in strong spots, including the Guardians.

Gavin Williams Cleveland Guardians MLB
Photo By - Reuters Connect. Cleveland Guardians pitcher Gavin Williams gets ready to throw.

It's a massive day for favorites!

My MLB moneyline predictions for Monday's slate back plenty of pricey favorites, including the Cleveland Guardians.

Before we dive in, be sure to check out all our MLB picks for Monday, Sept. 14.

MLB moneyline picks for Sept. 14

For help understanding Polymarket probabilities, see our odds calculator.

Matchup Pick
Dodgers Dodgers
vs
Reds Reds
Dodgers
67%
White Sox White Sox
vs
Guardians Guardians
Guardians
58%
Tigers Tigers
vs
Blue Jays Blue Jays
Blue Jays
56%
Orioles Orioles
vs
Mets Mets
Mets
54%
Braves Braves
vs
Cubs Cubs
Cubs
55%
Yankees Yankees
vs
Twins Twins
Yankees
54%
Giants Giants
vs
Cardinals Cardinals
Cardinals
57%
Padres Padres
vs
Rockies Rockies
Padres
66%
Mariners Mariners
vs
Angels Angels
Angels
49%
Marlins Marlins
vs
Diamondbacks Diamondbacks
Diamondbacks
55%

Prices courtesy of Polymarket as of Sept. 14.

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Expert MLB moneyline picks for Sept. 14

Dodgers vs Reds: Dodgers

Dodgers win probability: 66%

I am typically highly against paying this much juice for a team to secure a regular-season win. But with left-hander Nick Lodolo owning a 5.52 ERA and 1.57 WHIP over his last three starts, and the Reds' bats ice cold, the Dodgers are the play.

The Monstars of L.A. finally got their mojo back, as they've posted a 133 wRC+, .359 wOBA, and .816 OPS over their last six games. 

White Sox vs Guardians: Guardians

Guardians win probability: 58%

As someone who has invested a lot into this White Sox team this season, they are a corpse. This team is done. I do not see them winning this series, or even a game in this series.

They have Sean Burke on the bump tonight, who owns an 8.10 ERA over his last three starts. The lineup has posted a 77 wRC+, 28.6% strikeout rate, and 6.3% barrel rate over its last six games.

Guardians or nothing. If you find a prop for the Guardians to sweep, take it.

Tigers vs Blue Jays: Blue Jays

Blue Jays win probability: 56%

Name a hotter team than the Toronto Blue Jays right now. I’ll wait.

They own a wRC+ above 122 over their last 21 games while also posting an OPS above .781 and a strikeout rate below 20% during that span.

With how bad Troy Melton has been, the Blue Jays should tee off on him early and often at home this evening.

Orioles vs Mets: Mets

Mets win probability: 54%

The Mets' bats may be too hot to fade, as they own a sub-150 wRC+, .379 wOBA, and .869 OPS over their last six games. The Orioles have been alright at the dish, but nowhere near the Mets.

Neither Brandon Young nor Jonah Tong has been great over their last few outings, so we're trusting the hotter bats here.

Braves vs Cubs: Cubs

Cubs win probability: 55%

Neither pitcher in this matchup has been performing well recently, and neither have the Braves' bats, which is why we're on the Cubs this evening.

Atlanta has owned a wRC+ under 100 for over a month now while posting just a .134 ISO and 5.8% barrel rate over its last six games. Meanwhile, the Cubs' bats have been on fire for quite some time now.

I have zero trust in the Braves.

Yankees vs Twins: Yankees

Yankees win probability: 54%

The Yankees getting Aaron Judge back brings a massive boost to the lineup. Even if he's not performing at his best, his presence alone is lethal. 

Dean Kremer has also been so atrocious that he must be faded here. He owns a 7.62 ERA and 1.85 WHIP while allowing a 13.64% barrel rate over his last three outings.

On the other side, Will Warren has put up a 1.17 ERA and 0.91 WHIP during that stretch.

Giants vs Cardinals: Cardinals

Cardinals win probability: 57%

With the Giants losing Rafael Devers to injury, the morale this San Francisco lineup had been enjoying over the last few weeks is likely gone. Devers was on another planet, producing so many runs for this team, and they likely won't be able to make up for his loss.

Plus, Cardinals southpaw Quinn Mathews has been rock solid for the birds.

Birds or nothing. 

Padres vs Rockies: Padres

Padres win probability: 66%

Why on earth would we even debate trusting old man Tomoyuki Sugano to hold down anything?

San Diego owns a 143 wRC+, .372 wOBA, and .852 OPS over its last six games. Meanwhile, Sugano has an ERA pushing 8.00.

Mariners vs Angels: Angels

Angels win probability: 49%

It's never the most exciting play to back the Angels to secure a win because they don't really know how.

However, when Reid Detmers is on the mound, they normally get a good chance to come out on top, as he owns a 0.55 ERA and 0.76 WHIP over his last five outings.

The Angels' bats have come alive lately and should be able to tee off on Mariners southpaw Kade Anderson, who has posted a 4.11 ERA and 1.44 WHIP in his last three starts.

Marlins vs Diamondbacks: Diamondbacks

Diamondbacks win probability: 55%

Marlins starter Sandy Alcantara has completely fallen off a cliff, sporting an 8.27 ERA and 1.65 WHIP while allowing a hard-hit rate over 40% in his last three outings.

Diamondbacks right-hander Corbin Burnes looked great coming back last week, so he should be worth trusting, especially with how well Arizona's bats have been swinging.

It's the Snakes in this spot.

Odds are correct at the time of publishing and are subject to change.
Not intended for use in MA.
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Colby Marchio
Betting Analyst

Colby Marchio is a two-time DePaul alum and former Division 1 (club) baseball player who has been sports betting since 2019. Since graduating in 2021, he has worked throughout the media circuit, hosting and appearing on various television and radio shows while making countless guest appearances discussing Major League Baseball, college basketball, college football, and the National Football League.

A self-proclaimed numbers nerd, Colby may enjoy digging through the data even more than winning itself. That passion is why his two favorite sports to cover are college basketball and Major League Baseball. 

As for his favorite sportsbook, it is whichever one has the best price, or whichever one is not taxing him as an Illinois resident. 

You can find all of his plays and more @ColbyMBets on Twitter/X.

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