The St. Louis Cardinals and Arizona Diamondbacks meet tonight at Busch Stadium, with first pitch scheduled for 7:45 p.m. ET on ESPN.
My Cardinals vs. Diamondbacks predictions expect St. Louis to add to Zac Gallen's recent struggles. Read more in my MLB picks for tonight's action.
Who will win Diamondbacks vs Cardinals today: Cardinals moneyline (-126)
The Arizona Diamondbacks send Zac Gallen to the hill tonight, and the veteran continues to struggle. He owns a 6.10 ERA this season and a 6.00 FIP over his last two starts while allowing 1.80 home runs per nine innings.
Gallen has also surrendered a 40.2% hard-hit rate across his last 25 1/3 innings, making him vulnerable against the St. Louis Cardinals.
Michael McGreevy has been much steadier. He's allowed more than two earned runs just once in his last four starts and owns a strong 2.25 ERA at Busch Stadium this season.
I'll back McGreevy to outduel Gallen, and would play this pick up to -140.
COVERS INTEL: Zac Gallen owns a 6.23 FIP on the road this season compared to a 4.97 mark overall, suggesting how much he's struggled away from home. 
Diamondbacks vs Cardinals Over/Under pick: Over 8.5 (-131)
Outside of two starters who have been prone to allowing runs lately, we're also looking at a pair of bullpens in poor form. Arizona's relief corps owns a 5.63 FIP over the last week, while St. Louis has been even worse with a 6.38 FIP across the last 14 days.
Offensively, the Cardinals are batting .273 over their last 13 games while carrying a strong 119 wRC+. Arizona hasn't been as productive lately, but against a struggling Cardinals bullpen, the Diamondbacks should still find opportunities to contribute.
Play this to -140.
- ML/RL bets: 31-26, +2.65 units
- Over/Under bets: 32-24, +3.53 units
Diamondbacks vs Cardinals weather
Conditions at Busch Stadium should be mildly favorable for hitters tonight. Temperatures around 85°F and warm summer air could help the ball carry a bit farther, although light winds mean weather is unlikely to play a major role. It's a slight boost for offense rather than a significant one.
Diamondbacks vs Cardinals odds
- Moneyline: Diamondbacks +117 | Cardinals -122
- Run line: Diamondbacks +1.5 (-163) | Cardinals -1.5 (+156)
- Over/Under: Over 8.5 (-122) | Under 8.5 (+117)
Diamonbacks vs Cardinals trend
The Diamondbacks have cashed their team total Over in 31 of their last 50 road games for +10.10 units and a 17% ROI. Find more MLB betting trends for Diamondbacks vs. Cardinals.
How to watch Diamondbacks vs Cardinals and game info
| Location | Busch Stadium, St. Louis, MO |
| Date | Thursday, June 25, 2026 |
| First pitch | 7:45 p.m. ET |
| TV | ESPN |
| Diamondbacks starting pitcher | Zac Gallen (3-6, 6.10 ERA) |
| Cardinals starting pitcher | Michael McGreevy (3-6, 3.35 ERA) |
Diamondbacks vs Cardinals latest injuries
Odds are correct at the time of publishing and are subject to change.
Not intended for use in MA.
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