The Chicago Cubs are priced as -112 moneyline favorites tonight at Chase Field when they take on the Arizona Diamondbacks. The first pitch is scheduled for 9:40 p.m. ET.
With Clay Holmes in good form, I'm backing Chicago in my Cubs vs Diamondbacks predictions as they search for their third straight victory.
Read more in my MLB picks for Tuesday, Aug. 25.
Who will win Cubs vs Diamondbacks today: Cubs (-112)
Clay Holmes has looked solid since coming over to the Chicago Cubs at the trade deadline. The veteran has posted a 3.17 FIP across his last two outings, limiting walks and not allowing a single home run during that span.
Holmes has also held opponents to a 2.6% barrel rate, and while the Arizona Diamondbacks are swinging it relatively well, Holmes has the profile to contain them.
Brandon Pfaadt, meanwhile, owns a respectable 3.80 FIP over his previous two appearances, but he has given up 2.13 HR/9. That is dangerous against a Cubs lineup showing legitimate power, collecting a .261 ISO over its last six games.
While both arms are keeping their respective teams in games, Chicago’s home run upside gives the Cubs a slight edge against Pfaadt.
Play this pick up to -130.
COVERS INTEL: The Cubbies are raking right now with a 140 wRC+ across the last week. Their season average sits at +114. Chicago's offensive form gives it a clear upper hand. 
Cubs vs Diamondbacks Over/Under pick: Over 8.5 (-103)
I'm liking the Over tonight. Chicago’s bullpen has been excellent lately — which keeps this from being a slam-dunk angle — but both lineups are swinging it well enough to push this number.
The Cubs have been especially dangerous as I discussed earlier, while Arizona sits at a strong 116 wRC+ in the last week. Pfaadt’s recent home run issues also give Chicago a clear early scoring path.
The biggest factor is Arizona’s bullpen, which owns a 6.57 FIP over its last 26 2/3 frames while allowing 2.36 HR/9.
I’ll play this pick up to -120.
Cubs vs Diamondbacks home run prediction: Pete Crow-Armstrong (+355)
Pete Crow-Armstrong is an NL MVP candidate for a reason, and he’s scorching hot at the moment. The slugger has cracked three bombs in his last six games while posting a .417 ISO.
What really stands out is his 24.5-degree average launch angle during that span. He consistently puts the ball in the air, which is a dangerous setup against Pfaadt amid his HR issues.
Arizona’s bullpen has also been vulnerable to the long ball lately, giving PCA another path to leave the yard.
Chase Field may not be the easiest park to take deep, but Crow-Armstrong’s current profile gives him a real chance at No. 34.
Play this pick down to +300.
- ML/RL bets: 57-67, -18.38 units
- Over/Under bets: 68-53, +5.91 units
Cubs vs Diamondbacks weather
Chase Field weather is extremely hot but clear, with temperatures falling from 110°F to 102°F throughout the game window. Humidity is low, winds are light around 3-6 mph, and POP sits at 0%, so there’s no delay concern. If the roof is closed, weather impact is minimal; if open, the heat could slightly help carry.
Cubs vs Diamondbacks odds
- Moneyline: Cubs -112 | Diamondbacks +101
- Run line: Cubs -1.5 (+152) | Diamondbacks +1.5 (-168)
- Over/Under: Over 8.5 (-103) | Under 8.5 (-107)
Cubs vs Diamondbacks trend
The Chicago Cubs have hit the moneyline in 24 of their last 35 away games (+11.80 Units / 28% ROI). Find more MLB betting trends for Cubs vs. Diamondbacks.
How to watch Cubs vs Diamondbacks and game info
| Location | Chase Field, Phoenix, AZ |
| Date | Tuesday, August 25, 2026 |
| First pitch | 9:40 p.m. ET |
| TV | Peacock |
| Cubs starting pitcher | Clay Holmes (5-6, 2.49 ERA) |
| Diamondbacks starting pitcher | Brandon Pfaadt (7-1, 3.39 ERA) |
Cubs vs Diamondbacks latest injuries
Odds are correct at the time of publishing and are subject to change.
Not intended for use in MA.
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