The Chicago Cubs and St. Louis Cardinals wrap up a four-game set at Busch Stadium today, and my Cubs vs. Cardinals predictions and MLB picks expect the North Siders to pick up the win in convincing fashion.
First pitch for this June 26 tilt is set for 2:15 p.m. ET.
Cubs vs Cardinals prediction
My Cubs vs Cardinals best bet: Cubs -1.5 (+125 at BetMGM)
⚾ Pick Analysis
The Chicago Cubs have Shota Imanaga back on the bump, and the lineup has heated up to put 15 runs on the board in the past two games.
Imanaga threw 10 1/3 scoreless innings while scattering just six hits and two walks during his minor-league rehab assignment, and he heads into today’s start with a 2.82 ERA and 1.10 WHIP across 44 2/3 big-league frames.
St. Louis Cardinals righty Andre Pallante hasn’t been nearly as sharp with a 4.48 ERA and 1.31 WHIP.
In addition to the noted uptick in offense from the Cubbies, Chicago ranks fourth in wOBA and fifth in ISO against right-handed arms while also pacing the majors in both marks on the highway.
The Cards don’t pack the same punch at the plate.
St. Louis boasts a respectable 13th-ranked wOBA against lefties, but it comes alongside a run-of-the-mill 22nd-ranked ISO.
I’m anticipating Imanaga spinning a tidy game, and the Chicago bats staying hot at Busch Stadium this afternoon.
Cubs vs Cardinals same-game parlay (SGP)
🚀 SGP Analysis
This is a getaway day for both clubs, and while I don’t have confidence in Pallante holding the Cubbies in check, I also don’t anticipate Chicago putting crooked numbers upon crooked numbers on the board.
Turning to the final leg of this same-game parlay, Pallante has walked two or more batters in nine of 15 starts, and the Cubbies are patient at the dish with a fourth-ranked 9.5 BB% against righties over the past three years.
Cubs vs Cardinals odds
Cubs vs Cardinals live odds
Cubs vs Cardinals opening odds
- Moneyline: Chicago -135 | St. Louis +115
- Run line: Chicago -1.5 (+125) | St. Louis +1.5 (-150)
- Over/Under: Over 9 (-115) | Under 9 (-105)
Cubs vs Cardinals trend
The Chicago Cubs have hit the Under in 16 of their last 27 games (+6.25 Units / 21% ROI). Find more MLB betting trends for Cubs vs. Cardinals.
How to watch Cubs vs Cardinals and game info
Location | Busch Stadium, St. Louis, MO |
Date | Thursday, 6-26-2025 |
First pitch | 2:15 p.m. ET |
TV | MARQ, FDSN |
Cubs starting pitcher | Shota Imanaga (3-2, 2.82 ERA) |
Cardinals starting pitcher | Andre Pallante (5-3, 4.48 ERA) |
Cubs vs Cardinals latest injuries
Cubs vs Cardinals weather
Odds are correct at the time of publishing and are subject to change.
Not intended for use in MA.
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