The St. Louis Cardinals are -115 favorites to snap their three-game losing streak, but I don't believe that should be the case.
My Cardinals vs. Angels predictions and MLB picks see value in backing the -105 home underdogs on July 21.
Who will win Cardinals vs Angels today: Angels (-105)
To say the Los Angeles Angels have a starting pitching advantage in this game would be an understatement.
Walbert Urena has posted a sub-3.75 xERA in eight consecutive starts, and has only given up more than three runs once since April 25.
He is giving the Angels quality starts in bulk, and should be headed for another against a St. Louis Cardinals team that sits 27th in wOBA vs. righties over the past month.
The Angels own a .268 BA against lefties in July, and Matthew Liberatore bleeds hits — ranking in the 11th percentile in xBA.
Bet L.A. to -115.
COVERS INTEL: Urena ranks in the 92nd percentile with a .197 xBA this season.
Cardinals vs Angels Over/Under pick: Under 9.0 (-105)
I don't get this total.
Urena is sporting a 2.83 ERA and has allowed 0.63 homers per nine innings over five matchups with Bottom-10 teams in OPS vs. righties. The Cardinals not only fit the criteria but have also hit only .218 against right-handed pitching over the past 30 days.
While the Angels have strung together hits against southpaws, they sit 22nd in OPS and 29th in FB% in July.
It’ll be tough to generate homers, and I don’t see 10+ runs being scored without plenty of aid from power.
I like the Under to -125.
- ML/RL bets: 61-49, +1.60 units
- Over/Under bets: 60-45-5, +7.34 units
Cardinals vs Angels weather
Cardinals vs Angels odds
- Moneyline: Cardinals -115 | Angels -105
- Run line: Cardinals -1.5 (+145) | Angels +1.5 (-170)
- Over/Under: Over 9.0 (-115) | Under 9.0 (-105)
Cardinals vs Angels trend
Los Angeles has cashed the game total Under in 21 of its last 35 games (+6.95 units, 18% ROI). Find more MLB betting trends for Cardinals vs. Angels.
How to watch Cardinals vs Angels and game info
| Location | Angel Stadium, Anaheim, CA |
| Date | Tuesday, July 21, 2026 |
| First pitch | 9:38 p.m. ET |
| TV | Cardinals.TV, ABTV |
| Cardinals starting pitcher | Matthew Liberatore (5-6, 5.00 ERA) |
| Angels starting pitcher | Walbert Urena (5-7, 2.88 ERA) |
Cardinals vs Angels latest injuries
Odds are correct at the time of publishing and are subject to change.
Not intended for use in MA.
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