Best NRFI Picks Today: No Run First Inning Predictions for MLB May 22

Neil Parker - Analyst at Covers.com
Neil Parker • Betting Analyst 16+ years betting experience
Updated: May 22, 2026 , 11:56 AM ET • 4 min read

Phillies ace Cristopher Sanchez continues his first-inning brilliance.

Philadelphia Phillies, MLB, Cristopher Sanchez
Photo By - Reuters Connect. Philadelphia Phillies starting pitcher Cristopher Sanchez.

Get ready for the weekend with a trio of NRFI/YRFI bets for Friday, May 22!

My top MLB picks call for a low-scoring first frame between the Cleveland Guardians and Philadelphia Phillies, with the Texas Rangers and Los Angeles Angels also blanking the first inning to wrap up my betting card.

Best NRFI/YRFI picks today

Pick Odds
Guardians/Phillies - NRFI -139
Mariners/Royals - NRFI -121
Rangers/Angels - NRFI -127
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Guardians at Phillies: NRFI (-139)

Cleveland Guardians right-hander Gavin Williams and Philadelphia Phillies ace Cristopher Sanchez have both dazzled in the first inning this season.

Williams has held opposing hitters to a .222 batting average while tossing a scoreless first inning in seven of 10 starts, and it’s been a similar story for Sanchez. The southpaw has pitched a scoreless first in eight of 10 starts with a 2.70 ERA.

  • Time: 6:40 p.m. ET
  • Where to watch: NBCSP, CLEG

Mariners at Royals: NRFI (-121)

The Kansas City Royals have scored in the opening inning in just 24% of their games, tied for sixth-lowest in the majors.

Although Seattle Mariners starter Logan Gilbert has been hit for a 1.045 OPS in the first inning, he posted a .645 mark in 2025, making this a great spot for the righty to flip the early script.

Seattle also ranks 29th in wOBA against left-handed starters, and Royals southpaw Noah Cameron has fired a scoreless first inning in six of eight starts.

  • Time: 7:40 p.m. ET
  • Where to watch: ROYL, SEAM

Team at Team: Rangers at Angels: NRFI (-127)

While it might be asking a lot to back Los Angeles Angels right-hander Grayson Rodriguez, the Texas Rangers have scored in the first inning at the eighth-lowest rate in baseball this season. Rodriguez also held the Los Angeles Dodgers scoreless in the first inning in his season debut last time out.

Rangers righty Jacob deGrom is also due for some statistical correction in the opening frame. He’s allowed four first-inning home runs with a 1.010 OPS, but considering he’s surrendered just 10 total homers and a .625 OPS overall, those early struggles should start to subside.

  • Time: 9:38 p.m. ET
  • Where to watch: ABTV, CW33
Neil Parker's 2026 Transparency Record
  • NRFI/YRFI picks: 6-10, -4.27 units

Odds are correct at the time of publishing and are subject to change.
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Neil Parker - Covers
Betting Analyst

Neil Parker is, first and foremost, a sports fan. A huge supporter of the Cowboys, Cubs, and Maple Leafs, he has managed to parlay his passion into writing gigs at some of the top websites in the industry.

Neil takes a numbers-based approach to his handicapping and complements his in-depth statistical analysis with a keen eye on the markets to provide the best available odds. He loves to lean on his rolodex of idioms to offset his inner nerd. When it comes to wagering, he throws down on anything that catches his eye at bet365, Betway and BetVictor. He also keeps a close eye on CoolBet because the polar bear brand often has outlier NHL and NFL moneyline prices.

Neil graduated with honors from St. Thomas University in 2007 before completing his BEd at Acadia University in 2010. After teaching a myriad of courses and subjects, he found a groove delivering fun lessons to exceptional learners in non-traditional classroom environments. If his decade-plus teaching run taught him anything about sports betting, it’s to stay the course and use the summer – or offseason – to refresh and prepare to be better in the year to come.

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