UFC 322 Predictions, Picks & Best Bets for Tonight's Main Card

Get UFC 322 best bets and expert predictions for every main card fight. Break down each matchup with sharp insights from Covers' top analysts.

Trevor Knapp - Betting Analyst at Covers.com
Trevor Knapp • Betting Analyst
Nov 15, 2025 • 07:00 ET • 4 min read
Jack Della Maddalena UFC
Photo By - Imagn Images. Jack Della Maddalena (blue gloves).

UFC 322 returns to Manhattan tonight, with a stacked card taking center stage at Madison Square Garden.

Our UFC betting team has broken down every main-card fight with expert UFC 322 predictions, picks, and top plays.

UFC 322 best bets

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Della Maddalena vs Makhachev 

Rohit Ponnaiya

Best bet: Della Maddalena moneyline
+210 at BET99

Makhachev is one of the most well-rounded fighters in UFC history, combining elite grappling and wrestling with crisp kickboxing. That said, he was significantly bigger than his opponents at lightweight, an advantage he won't have after moving up a division. 

This line is too wide, especially after moving up for his first welterweight fight against a superior boxer in Della Maddalena. Take the current champ at plus money.

Read Rohit's full Della Maddalena vs. Makhachev predictions


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Shevchenko vs Weili 

Rohit Ponnaiya

Best bet: Shevchenko moneyline
-135 at BET99

Zhang is a pressure fighter who is at her best coming forward. Stylistically, that plays right into the hands of Bullet, who is a crisp counter striker and will land the cleaner shots.

Shevchenko will use her superior footwork to stay at range and avoid Zhang's power and takedown entries. She can also land takedowns of her own and could secure rounds with top control like Namajunas did.

Read Rohit's full Shevchenko vs. Weili predictions.


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Brady vs Morales

Danny Howard

Best bet: Brady moneyline
-140 at BET99

This is too soon for Morales. He hasn't faced someone who can put him on his back and keep him there. If he can’t hurt Brady early or force him to respect the striking advantage, Brady’s pressure and grappling efficiency will take over.

Morales is skilled enough to create danger, but Brady has reached the stage where he's winning not just with tools, but with maturity and awareness of when and where to impose his strengths. 

Read Danny's full Brady vs. Morales predictions


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Edwards vs Prates

Danny Howard

Best bet: Prates moneyline
-190 at BET99

In a three-round fight where activity matters, the risk of Edwards letting rounds drift is very real. If Edwards can turn back the clock now that he has someone who won’t be aggressively wrestling him, he can absolutely make Prates look reckless and predictable.

But recent evidence points toward a fighter struggling to commit, while Prates is trending upward and carrying real belief in his offensive identity.

Read Danny's full Edwards vs. Prates predictions


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Dariush vs Saint Denis

Chris Faria

Best bet: Saint Denis moneyline
-190 at BET99

BSD is on more of an upward trajectory. He got a new coach this year in Nicolas Ott, who also trains fellow Frenchman Nassourdine Imavov — one of the best strikers in the middleweight division.

I expect Saint Denis to showcase improved striking along with his same relentless pressure en route to victory.

Read Chris's full Dariush vs. Saint Denis predictions


Our best UFC 322 parlay


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+434 parlay

Tony Sartori

Pat Sabatini moneyline

Valentina Shevchenko by decision

Islam Makhachev moneyline

+434 at BET99

The previous meeting between these two resulted in a razor-close split decision for Mariscal, giving Sabatini a clear blueprint for adjustments. With improved control and a more wrestling-heavy approach, Sabatini has strong value on the moneyline in what should be another competitive but winnable fight.

Zhang will need to take big risks just to crash the pocket, which increases her exposure to counters and takedown attempts. All signs point to Shevchenko edging a technical contest and winning on the scorecards.

Makhachev’s striking is far sharper and more defensively sound than Belal’s. Once this fight hits the mat, the skill gap becomes enormous, and the longer the fight goes, the more dominant Islam will look. Expect Makhachev to impose his game, drown JDM with pressure, and cruise to a victory either on the cards or with a late submission.

Read a full analysis of Tony's UFC 322 parlay picks.


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Trevor Knapp - Covers
Betting Analyst

Trevor joined the Covers content team as a publishing editor in early 2022. Growing up in Vancouver, he studied Broadcast and Online Journalism at the British Columbia Institute of Technology (BCIT), and interned with TSN and Sportsnet Radio while also writing for the Daily Hive.

An avid bettor of the MLB, NFL, and CFL, Trevor advises his fellow sports bettors to leave their hearts at the door and not hesitate to fade their favorite team. It's a strategy he follows regularly as an apathetic Indianapolis Colts and Toronto Blue Jays fan.

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