| Player | POS | Team | NUM | Height | Weight | DOB |
|---|---|---|---|---|---|---|
| Obada, Efe | DE | BUF | 93 | 6'6" | 265 lbs | Apr 13, 1992 |
| O'Connor, Patrick | DL | TB | 79 | 6'4" | 270 lbs | Nov 1, 1993 |
| O'Daniel, Dorian | LB | KC | 44 | 6'1" | 220 lbs | Sep 4, 1994 |
| Odenigbo, Ifeadi | DE | CLE | 57 | 6'3" | 258 lbs | Apr 8, 1994 |
| Odeyingbo, Dayo | DE | IND | 54 | 6'6" | 276 lbs | Sep 24, 1999 |
| Odighizuwa, Osa | DT | DAL | 97 | 6'2" | 280 lbs | Aug 13, 1998 |
| O'Donnell, Pat | P | CHI | 16 | 6'4" | 212 lbs | Feb 22, 1991 |
| Odum, George | S | IND | 30 | 6'1" | 202 lbs | Nov 3, 1993 |
| Ogbah, Emmanuel | DE | MIA | 91 | 6'4" | 275 lbs | Nov 6, 1993 |
| Ogbongbemiga, Amen | LB | LAC | 57 | 6'0" | 231 lbs | Sep 4, 1998 |
| Ogbuehi, Cedric | T | SEA | 70 | 6'5" | 308 lbs | Apr 25, 1992 |
| Ogletree, Alec | LB | CHI | 44 | 6'3" | 250 lbs | Sep 25, 1991 |
| Ogunbowale, Dare | RB | JAC | 33 | 5'10" | 205 lbs | May 4, 1994 |
| Ogundeji, Adetokunbo | LB | ATL | 92 | 6'4" | 268 lbs | Oct 9, 1998 |
| Ogunjobi, Larry | DT | CIN | 65 | 6'4" | 305 lbs | Jun 3, 1994 |
| Ojemudia, Michael | CB | DEN | 13 | 6'1" | 200 lbs | Sep 12, 1997 |
| Ojulari, Azeez | LB | NYG | 51 | 6'2" | 249 lbs | Jun 16, 2000 |
| Okafor, Alex | DE | KC | 97 | 6'4" | 261 lbs | Feb 8, 1991 |
| Okereke, Bobby | LB | IND | 58 | 6'1" | 235 lbs | Jul 29, 1996 |
| Okorafor, Chukwuma | OL | PIT | 76 | 6'6" | 320 lbs | Aug 8, 1997 |
| Okoronkwo, Ogbonnia | LB | LAR | 45 | 6'2" | 253 lbs | Apr 24, 1995 |
| Okudah, Jeff | CB | DET | 23 | 6'1" | 202 lbs | Feb 2, 1999 |
| Okwara, Julian | DE | DET | 99 | 6'4" | 245 lbs | Dec 27, 1997 |
| Okwara, Romeo | DE | DET | 95 | 6'4" | 255 lbs | Jun 17, 1995 |
| Okwuegbunam, Albert | TE | DEN | 85 | 6'5" | 258 lbs | Apr 25, 1998 |
| Oliver, Ed | DT | BUF | 91 | 6'1" | 287 lbs | Dec 12, 1997 |
| Oliver, Isaiah | CB | ATL | 26 | 6'0" | 210 lbs | Sep 30, 1996 |
| Oliver, Josh | TE | BAL | 84 | 6'5" | 249 lbs | Mar 21, 1997 |
| Olonilua, Sewo | FB | DAL | 45 | 6'3" | 240 lbs | Nov 27, 1997 |
| Olszewski, Gunner | WR | NE | 80 | 6'0" | 190 lbs | Nov 26, 1996 |
| Oluokun, Foyesade | LB | ATL | 54 | 6'2" | 215 lbs | Aug 2, 1995 |
| Omenihu, Charles | DL | HOU | 94 | 6'5" | 280 lbs | Aug 20, 1997 |
| O'Neill, Brian | T | MIN | 75 | 6'7" | 310 lbs | Sep 15, 1995 |
| Onwenu, Mike | OL | NE | 71 | 6'3" | 350 lbs | Dec 10, 1997 |
| Onwuzurike, Levi | DT | DET | 75 | 6'3" | 295 lbs | Mar 3, 1998 |
| Onyemata, David | DT | NO | 93 | 6'4" | 300 lbs | Nov 13, 1992 |
| Oruwariye, Amani | CB | DET | 24 | 6'2" | 205 lbs | Feb 9, 1996 |
| Orzech, Matthew | LS | LAR | 42 | 6'3" | 245 lbs | Apr 12, 1995 |
| Osborn, K.J. | WR | MIN | 17 | 5'11" | 203 lbs | Jun 10, 1997 |
| O'Shaughnessy, James | TE | JAC | 80 | 6'4" | 245 lbs | Jan 14, 1992 |
| Ossai, Joseph | DE | CIN | 58 | 6'4" | 253 lbs | Apr 13, 2000 |
| Ott, Tyler | LS | SEA | 69 | 6'3" | 253 lbs | Feb 28, 1992 |
| Overton, Matt | LS | LAC | 54 | 6'1" | 254 lbs | Jul 6, 1985 |
| Oweh, Odafe | LB | BAL | 99 | 6'5" | 251 lbs | Dec 15, 1998 |
| Owusu-Koramoah, Jeremiah | LB | CLE | 28 | 6'2" | 221 lbs | Nov 4, 1999 |
