Week 13 NFL Parlay Picks: Mixon Hits Paydirt Again

Week 13 could deliver some close calls as teams fight for their playoff lives and jockey for position. As we hit the regular season's home stretch, check out our best NFL parlay picks for this weekend's action.

Dec 4, 2021 • 14:53 ET • 4 min read
Joe Mixon Cincinnati Bengals NFL
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We could be in for some close calls in Week 13. Of the 13 remaining NFL games, seven have spreads with numbers under a touchdown. That's a good indicator that we’re in for a competitive week of difficult-to-predict contests.

That said, we’re here to help make the most of your Week 13 wagers. Here's a look at my favorite spreads, totals and player prop bets that I'll be targeting in Week 13.

Week 13 NFL parlay picks

Click on each pick to jump to the full analysis.

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PARLAY: New York Jets +6.5 (-110) + New York Giants at Miami Dolphins 1st Half Under 21.5 (-110) = +264

New York Jets +6.5 (-110)

The Philadelphia Eagles travel to New York to take on the Jets. The Eagles struggled last week, losing to the New York Giants 13-7, and looked extremely out-of-sync offensively. Eagles quarterback Jalen Hurts is coming off a 14-of-31 game for 129 yards, 0 touchdowns and 3 interceptions.

As bad as the Jets have been all year, they're coming off a victory last week versus the Houston Texans on the road, and have looked much better defensively. They held the Texans under 100 total rushing yards and barely allowed over 100 the week prior versus the Miami Dolphins. Look for the Jets to keep this one within a spread that is far too big.

New York Giants at Miami Dolphins 1H Under 21.5 (-110)

Mike Glennon gets the start for the New York Giants with Daniel Jones sidelined with a strained neck. He's hoping to find more success as a starter, entering with a 6-21 record. The Giants meet a Miami Dolphins team who are playing to keep their playoff hopes alive, entering Sunday's contest on a four-game winning streak. Throughout that stretch they’ve shone defensively, holding three of their last four opponents to 10 points or less.

When it comes to slow starts, both teams rank in the Bottom 10 in first-half points per game. The Dolphins are averaging 9.3 first-half points, with the Giants averaging only 7.4. Expect a slow start in a game that will have points at a premium.

PARLAY: Anytime Touchdown Scorer: Joe Mixon (-120) + San Francisco 49ers -3 (-110) = +250

Anytime Touchdown Scorer: Joe Mixon (-120)

The Los Angeles Chargers travel to Cincinnati to take on the Bengals, who have looked so much sharper on offense since their Week 10 bye week. They’ve scored 30 or more points in six straight contests and find themselves in a favorable matchup versus a Chargers team who have struggled to stop the run all season long.

Joe Mixon has had a successful campaign, particularly as of late, eclipsing 120+ rushing yards in back-to-back contests and finding the endzone at least twice in three straight. He’s only been held out of the endzone three times all year, and it doesn't look likely that Week 13 will make it four.

San Francisco 49ers -3 (-110)

The Seattle Seahawks have lost six of their last seven games and return home fresh off a Monday night loss versus the Washington Football Team. They host one of the league's hottest teams in the San Francisco 49ers, who are averaging an incredible 178.3 rushing yards per game over their last three contests. They have controlled the line of scrimmage and, throughout that three-game stretch, have attempted a league-high average of 41 rushing attempts per game.

The Seattle defense is in for a long night as it has struggled to stop the run and now meets a 49ers squad on a short week. With Deebo Samuel questionable with a groin injury, look for the Niners to control the clock and put a dagger in the Seahawks’ already disappointing season.

NFL parlays

Did you know that if you parlayed this week's NFL parlay picks, you could win $127.40 on a $10 bet?

Use our NFL parlay calculator to create your own parlays and see their potential payouts.

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