In a battle between 0-2 teams desperate for a turnaround, the Texans are a 53% favorite on the road and own the clear offensive edge against a Colts unit scrambling for answers.
TOP Pick
Texans vs Colts prediction: Texans -1.5
The Houston Texans’ defense has already been tested by two of the NFL's most dangerous offenses in the Buffalo Bills and Cincinnati Bengals, yet the unit still holds a significant statistical advantage over the Indianapolis Colts in nearly every category.
Indianapolis has been a disaster defensively, surrendering an NFL-worst 514 total yards per game, nearly 60 yards more than any other team. The Colts are also giving up a league-high 37 points per contest. David Montgomery should also have an opportunity to do plenty of damage on the ground against a Colts defense surrendering 5.4 yards per carry through two weeks.
That's a difficult matchup against a Houston offense sitting inside the top 10 in yards per game. It gives me plenty of confidence backing C.J. Stroud and the Texans, even if Nico Collins remains sidelined.
I’m comfortable fading Indianapolis in this matchup and would play the Texans up to 58%.
COVERS INTEL: The Texans are dawgs on the road: across their last five away games, they're 
Texans vs Colts combo
The Texans have no business losing this game - they're better than the Colts in all three facets, and if they can limit the impact of Colts running back Jonathan Taylor, the offense should be able to handle the worst defense in football. With that in mind, I'm backing Stroud and Montgomery, who are 3-1 overall against these respective numbers.
Texans vs Colts combo
- Texans -2.5
- David Montgomery 50+ rushing yards
- C.J. Stroud 250+ passing yards
Texans vs Colts touchdown scorer: David Montgomery
The Colts own one of the worst red-zone defenses in the NFL, allowing teams to score at a near-70% clip when opponents reach their 20. This bodes well for Montgomery, who's being used the third-most in the red zone of any other running back in football, totaling six attempts for 19 yards and two touchdowns.
Suffice it to say, when they get down by the goal line, Montgomery is their man.
- Top picks: 15-11, +3.64 units
- Combos: 0-0, +0.00 units
Texans vs Colts odds
For help understanding probabilities, see our odds calculator.
- Spread: Texans -1.5 | Colts +1.5
- Over/Under: Over 42.5 (51%) | Under 42.5 (50%)
- Moneyline: Texans 53% | Colts 47%
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Texans vs Colts weather
Lucas Oil Stadium has a retractable roof, so the weather won't impact the game.
Check out our NFL weather page for up-to-date info on every matchup.
Texans vs Colts trend to know
The Texans are 5-0 ATS in their last five games following a double-digit loss at home. Find more NFL betting trends for Texans vs. Colts.
How to watch Texans vs Colts
| Location | Lucas Oil Stadium, Indianapolis, Ind. |
| Date | Sunday, Sept. 27, 2026 |
| Kickoff | 1 p.m. ET |
| TV | CBS |
Texans vs Colts latest injuries
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