Thanksgiving supercharges the NFL odds, with a trio of games on Thursday and a standalone showdown on Black Friday before Sunday's big board.
With everyone home for the holiday, books are bracing for ample action as everyone makes their NFL Week 13 picks.
The recipe for the perfect bet always begins with getting the best of the number to support your side or total. I help you do just that, highlighting the best NFL picks to make NOW and some you may want to consider LATER.
NFL predictions: Week 13 bet now, bet later picks
- Texans (+3.5) at Colts: Bet Now
- Spread to Bet Later: TBD
- Vikings at Seahawks (Under 43.5): Bet Now
- Total to Bet Later: TBD

Houston Texans (+3.5) at Indianapolis Colts: Bet Now
The Indianapolis Colts had the Chiefs’ season on life support, but Kansas City came back from the dead and dealt Indy a gutting loss in overtime. The defense was on the field for almost 43 minutes and now takes on a well-rested rival.
The Houston Texans get a mini-bye after besting Buffalo on Thursday and could have QB1 C.J. Stroud back from a concussion in Week 13. The Texans defense is powering the team’s three-game winning streak, holding four of its last five foes to 19 points or less.
Indy couldn’t get RB Jonathan Taylor going against Kansas City, and QB Daniel Jones looked more like his former self than the revived version we’ve seen so far with the Colts. Houston is a Top 10 run-stop unit and sits tied for third in total sacks (33).
An update on Stroud’s status will likely tip this spread to a field goal, so if you’re selling the Colts and buying the Texans’ streak, you’ll want to get that half-point hook on the road underdog.
Best odds to bet Texans +3.5 right now
Spread to Bet Later
Coming soon.
Covers NFL betting tools
- NFL odds
- NFL picks
- NFL player props
- Super Bowl 60 odds
- Best NFL betting sites
- This week’s NFL matchups
Minnesota Vikings at Seattle Seahawks (Under 43.5): Bet Now
It’s safe to say J.J. McCarthy has work to do if he’s going to be the Minnesota Vikings' answer under center.
The first-year starter finished 12-for-19 passing for a measly 87 yards along with two interceptions in the road loss at Green Bay in Week 12. The Vikings have failed to crack 20 points in three straight games and now head to Lumen Field to take on another elite defense.
The Seattle Seahawks got a bit of a scare in Tennessee on Sunday, but still limited the Titans to 17 points, checking them to 4.4 yards per play and sacking rookie QB Cam Ward four times.
Sam Darnold takes on his former club and needs to be wary of the Vikings’ blitz-heavy schemes. That means quicker hits and lots of handoffs, with little time in the pocket for deeper strikes to develop.
This total opened just shy of the key number of 44 points and is already sinking like a stone in the opening hours of action. Grab the Under 43.5 now, as the next stop is 42.5 with little reason to like the Over.
Best odds to bet Under 43.5 right now
Total to Bet Later
Coming soon.
Odds are correct at the time of publishing and are subject to change.
Not intended for use in MA.
Affiliate Disclosure: Our team of experts has thoroughly researched and handpicked each product that appears on our website. We may receive compensation if you sign up through our links.






