The wait is over! NFL action returns tonight as the Los Angeles Chargers take on the Detroit Lions in the 2025 Hall of Fame Game at Tom Benson Stadium in Canton, Ohio.
While the starters will stay on the sidelines, this preseason opener marks the first chance for bettors to get in on the action. Whether you're looking for value in the point spread, total, or player props, it's time to shake off the offseason rust and start betting on live NFL football.
Here are my top Chargers vs. Lions predictions and NFL picks for the Hall of Fame Game on Thursday, July 31.
Lions vs Chargers prediction
Lions vs Chargers best bet: Chargers moneyline (+115 at bet365)
The Los Angeles Chargers are set to give quarterback Trey Lance a lengthy look behind center in the Hall of Fame Game after a solid start to training camp. The second-overall pick from 2021 also offers upside as a rushing threat from behind center.
Lance is set to play into the third quarter, while the Detroit Lions will counter with quarterbacks Hendon Hooker and Kyle Allen.
I expect the Chargers to field more competitive personnel on both sides of the ball, with the Lions looking further ahead as a betting favorite in the Super Bowl odds.
The combination of Lance receiving a long look and intriguing pass-catchers Tre Harris, KeAndre Lambert-Smith, and Dalevon Campbell, all likely to see the field, I like the Chargers to squeak out a win Thursday night.
We should also get a glimpse of Bolts RB Omarion Hampton, who’s trading among the betting favorites in the Offensive Rookie of the Year odds.
Lions vs Chargers total
Lions vs Chargers Over/Under bet: Over 33 (-110 at bet365)
The total is set at just 33 with -110 odds on both sides. Each of the last three Hall of Fame Games has gone Over that number with an average of 38.0 points per game.
There’s potential for the Chargers and Lions to batten down the defensive hatches, but I expect the Over to hit for a fourth consecutive year.
Strong defense can also set up short fields, and there’s also always the chance we see turnovers or disruptive defensive plays translate into points on the board, too.
Lions vs Chargers odds
Lions vs Chargers live odds
Lions vs Chargers opening odds
- Spread: Detroit -1 (-105) | Los Angeles +1 (-115)
- Moneyline: Detroit -110 | Los Angeles -110
- Over/Under: Over 32.5 (-110) | Under 32.5 (-110)
Odds courtesy of bet365
How to watch Lions vs Chargers
| Location | Tom Benson Hall of Fame Stadium, Canton, Ohio |
| Date | Thursday, July 31, 2025 |
| Kickoff | 8:00 p.m. ET |
| TV | NBC |
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