The NFL is back to dominate our lives for the next six months with the Cowboys and Eagles opening the season in Philadelphia on Thursday night.
My Cowboys vs. Eagles predictions believe the defending champs and their fans will be fired up to hang another banner and bring last season’s momentum into the game, while the Cowboys will have a lot working against them with the dust still settling on the trade of their best defensive player in a very long time in Micah Parsons.
Read on for my NFL picks for Thursday, September 4.
Cowboys vs Eagles prediction
Cowboys vs Eagles Best bet: Eagles -8 (-115)
I think we could have a bloodbath on our hands in the season opener.
While the Philadelphia Eagles are clearly one of the best teams in the league with a great home field advantage, the Dallas Cowboys enter the game and the season with an avalanche of red flags.
I don’t think it’s realistic to expect the best version of Dak Prescott right off the bat. He missed the final nine games of last season after undergoing hamstring surgery, and in the games he did play in, he struggled.
Dak posted a career-worst QB rating in 2024 and will now be tasked with leading this Cowboys offense against an Eagles defense that allowed just 16.6 points per game last season, and who also led the NFL in yards allowed per pass attempt.
The Eagles enter the season on a 10-game home winning streak and annihilated the Cowboys by a score of 41-7 when the teams last met in Philadelphia in December of last season. Yes, Dak Prescott didn’t play, but neither did Jalen Hurts.
Let’s also consider that Brian Schottenheimer is making his head coaching debut. I’m sure he’d much rather be hosting the Giants at home than being in an uncomfortable environment against a great team while dealing with a bunch of drama as he tries to prepare his team for a new season.
All factors taken into account, I can’t find a credible reason to believe the Cowboys will keep it close.
Cowboys vs Eagles TNF same-game parlay
With the potential for a blowout, or at the very least, the Eagles offense easily going up and down the field on the Cowboys defense, I expect Dallas to be playing from behind and for Dak to be throwing a lot.
Look for the Eagles to get Saquon Barkley heavily involved for obvious reasons, too.
Our big-ticket SGP: Hurts gets his fill
- Let's throw in Hurts to go Over his rushing yards vs. a Dallas defense that allowed the most rushing yards per game to QBs last season.
Cowboys vs Eagles game predictions
Cowboys vs Eagles moneyline prediction
These are two teams going in wildly different direction. Never mind winning, I don’t even think Dallas can keep this one close. Give me the Eagles to extend their home winning streak to 11 games.
Cowboys vs Eagles spread prediction
I expect the Eagles to be fired up in front of their home fans, while the Cowboys simply have too much to overcome this early in the season to keep this game competitive. The wheels could come off early for Dallas, and I think the Eagles cover the spread with ease.
Cowboys vs Eagles Over/Under prediction
While I have no doubt that the Eagles will find the end zone with regularity, I don’t have the same confidence in a potentially rusty Prescott going against a defense that allowed just 16.6 points per game at home last season. As a result, I think the game stays Under.
Cowboys vs Eagles odds
- Spread: Dallas +8 | Philadelphia -8
- Moneyline: Dallas +325 | Philadelphia -425
- Over/Under: Over 47.5 | Under 47.5
Cowboys vs Eagles betting trend to know
The Cowboys have only covered the 4Q spread in five of their last 17 games. Find more NFL betting trends for Cowboys vs. Eagles.
How to watch Cowboys vs Eagles
| Location | Lincoln Financial Field, Philadelphia, PA |
| Date | Thursday, September 4, 2025 |
| Kickoff | 8:20 p.m. ET |
| TV | NBC |
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