The Tulane Green Wave have a chance at revenge, and no chance should be entirely dismissed, but with the Mississippi Rebels furious at their former head coach, the world should expect to see the Green Wave turned into nothing but a ripple in the first round of the College Football Playoff.
My Tulane vs. Mississippi predictions and college football picks expect a full-throttle repeat of the September matchup between these two on Saturday, December 20.
Tulane vs Mississippi predictions for the CFP First Round
Who will win Tulane vs Mississippi?
Mississippi will.
Yes, anything can happen on any given Saturday. The beauty of single-elimination tournaments is that Saint Peter’s can beat Kentucky, Furman can beat Virginia, and Yale can beat Auburn.
But Mississippi is 11-0 outright as a favorite this season, and the homefield advantage in this moment should remove some of the intangibles that make March Madness so rife for upsets.
Tulane vs Mississippi best bet: Mississippi -17.5 (-104)
Back in September, Mississippi trounced Tulane, 45-10. The concerns then should continue this weekend.
The Green Wave did not find success through the air or on the ground, but they were particularly wretched when passing the ball, losing 0.24 expected points per dropback compared to losing just 0.08 points per rush attempt. The most dooming reality was springing just three explosive plays on 82 snaps.
Unfortunately for Tulane, there is no reason to expect any of that to change. The Green Wave prefer to throw the ball, dropping back 2.6% more often than an average team would in a given game state, according to CFB-graphs.com, and they do so rather well while their rushing attack is middling at best.
However, Mississippi has one of the country’s best pass defenses, ranking No. 16 in expected points added (EPA) per dropback against.
There is no reason to expect Tulane to find offensive success, and with the Rebels out to prove to the world that they are more than Lane Kiffin, not even the hook should scare you away from this spread.
Enjoying Covers content? Add us as a preferred source on your Google account
Tulane vs Mississippi same-game parlay
Tulane’s failures should set up more Mississippi scoring opportunities, particularly since the Rebels mount scoring opportunities at the best rate in the country, turning 59.3% of possessions into quality drives, per CFB-graphs.com.
At least one of those scoring opportunities should benefit Trinidad Chambliss; the quarterback ran for at least one score in three of Mississippi’s six one-score games, accounting for five of his six rushing touchdowns this year.
Tulane vs Mississippi SGP
- Mississippi -17.5
- Tulane team total Under 20.5
- Trinidad Chambliss anytime touchdown
Our deep-ball SGP: Rubbing It In
This is about more than a mere playoff win. The Rebels’ roster has said enough publicly to make it clear there is anger directed at Lane Kiffin. Mississippi offensive coordinator Charlie Weis Jr. may be headed to LSU, but he can still indulge this offense in airing its grievances.
Expect the Rebels to flex a bit — at Tulane’s expense, but aimed squarely at Kiffin.
Tulane vs Mississippi SGP
- Mississippi -17.5
- Tulane team total Under 20.5
- Trinidad Chambliss anytime touchdown
- Over 56.5
Tulane vs Mississippi odds
- Spread: Tulane +17.5 (-110) | Mississippi -17.5 (-110)
- Moneyline: Tulane +610 | Mississippi -900
- Over/Under: Over 56.5 (-110) | Under 56.5 (-110)
Tulane vs Mississippi trend to know
Mississippi went 5-1-1 against the spread at home against FBS competition this season. Find more college football betting trends for Tulane vs Mississippi.
How to watch Tulane vs Mississippi
| Location | Vaught-Hemingway Stadium, Oxford, MS |
| Date | Saturday, December 20, 2025 |
| Kickoff | 3:30 p.m. ET |
| TV | TNT |
Tulane vs Mississippi latest injuries
Tulane vs Mississippi weather
Monitor gametime conditions with our College football weather info.
Odds are correct at the time of publishing and are subject to change.
Not intended for use in MA.
Affiliate Disclosure: Our team of experts has thoroughly researched and handpicked each product that appears on our website. We may receive compensation if you sign up through our links.
