Southern Miss vs Alabama Picks and Predictions: Time for the Tide to Get Rolling

Alabama is yet to hit its stride in 2021 and that is bad news for a Southern Miss team visiting this weekend. Find out if the Crimson Tide can get going and cover a 45-point spread against the Golden Eagles with our picks.

Last Updated: Sep 24, 2021 4:54 PM ET Read Time: 4 min
Bryce Young Alabama Crimson Tide college football
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The No. 1 ranked Alabama Crimson Tide survived a scare from the Florida Gators last week, gutting out a 31-29 victory in the Swamp.

But the Tide were two-touchdown favorites and cruising before almost collapsing in the second half. Does Bama take out its frustrations on the Southern Miss Golden Eagles as massive 45-point chalk, or is that enough points to consider the underdogs in this spot?

Find out with our free college football betting picks and predictions for Southern Miss vs Alabama on Saturday, September 25.

Southern Miss vs Alabama odds

Odds via the Covers Line, an average comprised of odds from multiple sportsbooks.

Alabama hit the board as 44.5-point home favorites and have ticked up slightly to 45. The total opened at 57 and the early money has been on the Over, moving the number up to 58.5. Use the live odds widget above to track any future line movements right up until kickoff and be sure to check out the full college football odds before placing your bets.

Southern Miss vs Alabama picks

Picks made on 9/24/2021 at 4:00 p.m. ET.
Click on each pick to jump to the full analysis.

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Southern Miss vs Alabama game info

Location: Bryant-Denny Stadium, Tuscaloosa, AL
Date: Saturday, September 25, 2021
Time: 7:30 p.m. ET
TV: SEC Network

Southern Miss vs Alabama betting preview


Be sure to monitor the gametime conditions with our NCAA football weather info.

Key injuries

Southern Miss: Trey Lowe QB (Questionable).
Alabama: Brian Robinson RB (Questionable), Kendall Randolph TE (Questionable).
Find our latest NCAA football injury reports.

Betting trend to know

Alabama is 7-0 ATS in its last seven games against a team with a losing record. Find more NCAA betting trends for Southern Miss vs. Alabama.

Southern Miss vs Alabama predictions

Alabama started last week’s game against Florida pretty well, roaring out to a 21-3 lead. But then the Gators' defense clamped down and the offense slowly brought them back into the game. In fact, Florida ended up outgaining the Tide when all was said and done. 

So, Nick Saban has plenty of material to motivate his team with this week. Alabama is still one of the best teams in the country but they are young and, unfortunately for Southern Miss, it might be an undeserving victim in the wrong place at the wrong time.

Bryce Young, while he stumbled a bit down the stretch last week, has still put up outstanding numbers. The sophomore signal-caller is completing 68 percent of his passes for 811 yards with 10 touchdowns, and he has yet to throw a pick this season. 

Southern Miss has played some defense so far this season but that came against Southern Alabama, Grambling State, and Troy. Meanwhile, the Golden Eagles offense has yet to take flight, ranking 123rd in total offense and 117th in scoring offense. It will be a mild miracle if they score more than once in this game.

Alabama has yet to play a full 60 minutes. Saban will make an example of Southern Miss here.

If this feels like it is a bit of an insurance bet if Alabama does take its foot off the gas in the second half, that’s because it is.

Alabama continues to be a first-half spread monster over the past few seasons, going 2-1 ATS, and there is a good reason why. They rank ninth in the country in first-half scoring putting up 24 points per game while conceding just six points per game before the break. 

Considering how pissed off Saban must be about the Tide’s season thus far they should come out blazing in this one and with Southern Miss averaging just five first-half points per game this season, we’re betting Bama jumps out a big lead before the bands hit the field.

NCAA parlays

Did you know that if you parlayed our Southern Miss vs. Alabama picks, you could win $25.00 on a $10 bet?

Use our college football parlay calculator to create your own parlays and see their potential payouts.

Where can I bet on college football odds?

You can bet on college football odds at every online and casino sportsbook, including NCAA moneylines, spreads, Over/Under totals, and a ton of college football prop odds. Head over to our best football betting sites for the top spots to bet on college football odds in your area.

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