Once the ACC’s premier matchup, Clemson vs. Florida State is now more about minimizing disappointment than chasing conference glory.
Florida State ended a four-game skid with a convincing win over Wake Forest, keeping its bowl hopes intact. Clemson, on the other hand, enters on a two-game losing streak and is trying to avoid a rare third straight defeat.
I break it all down in my Clemson vs. Florida State predictions and college football picks for Saturday, November 8.
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Florida State vs Clemson prediction
Florida State vs Clemson best bet: Cade Klubnik Over 1.5 passing touchdowns (-172)
Standing out like a sore thumb in this matchup is the Florida State Seminoles' pass defense. I'm choosing to capture the value via Cade Klubnik's passing touchdowns.
Even at a price of -172, with my fair near -200, there's some value in this number.
The Noles' defense ranks 70th nationally in EPA per dropback heading into this matchup. While that's not terrible, it's more concerning when you look at a Clemson Tigers offense that has shown borderline-elite efficiency, ranking 22nd in EPA per dropback nationally.
What's a little more worrisome for the Noles is what's revealed when you look under the hood.
The pass explosiveness allowed by Florida State this season ranks in the bottom 11th percentile of college football. That plays a twofold role in this play.
Yes, directionally it means Clemson should have success through the air throughout the game, but it also has specific relevance to this play.
The more explosive plays Florida State allows through the air, the fewer red zone opportunities there are where Clemson would decide to run the ball in. Throw in the fact this matchup likely sees the two teams trading punches—which is more conducive to throwing the ball—and I can't pass this up.
Florida State vs Clemson same-game parlay
The most apparent angle in this matchup is Clemson's success through the air against a poor passing defense.
I'll back that angle and throw in the Tigers getting off to a strong start in a sport where they are desperate to break a recent losing streak.
Florida State vs Clemson SGP
- Cade Klubnik Over 1.5 passing touchdowns
- Cade Klubnik Over 281.5 passing yards
- Clemson 1H moneyline
Our deep-ball SGP: Air raid
I'm building on this same-game parlay by continuing to believe that Florida State is vulnerable through the air. I'll back Adam Randall to go over a small receiving yards number with his recent uptick. I'll finish by having Duce Robinson exceed his yardage total through the volume of plays he'll see. The 6-foot-6 junior has been a superstar for the Noles this season. With a game script that likely sees them trailing, he'll be force-fed.
Florida State vs Clemson SGP
- Cade Klubnik Over 1.5 passing touchdowns
- Cade Klubnik Over 281.5 passing yards
- Clemson 1H moneyline
- Adam Randall Over 17.5 receiving yards
- Duce Robinson Over 69.5 receiving yards
Florida State vs Clemson game predictions
Florida State vs Clemson moneyline prediction
Clemson. These teams are so evenly matched that it's truly a coin flip, but I'll side with the home team making a few more plays.
Florida State vs Clemson spread prediction
Clemson. Again, there's not a huge edge here, but in a matchup where each team has a clear advantage, I'll back the home team with the better head coach.
Florida State vs Clemson Over/Under prediction
I lean towards the Under with one strong defense on the field but it's not a strong play as my projection of 55 indicates.
Florida State vs Clemson odds
- Spread: Florida State +2.5 (-110) | Clemson -2.5 (-110)
- Moneyline: Florida State +100 | Clemson -120
- Over/Under: Over 55.5 (-110) | Under 55.5 (-110)
Florida State vs Clemson trend to know
Clemson has hit the team total Under in four of its last five games at home (+2.85 Units / 50% ROI). Find more college football betting trends for Florida State vs Clemson.
How to watch Florida State vs Clemson
| Location | Memorial Stadium, Clemson, SC |
| Date | Saturday, November 8, 2025 |
| Kickoff | 7:00 p.m. ET |
| TV | ACC Network |
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