When will we be able to trust Kentucky again? Well, it won't be this evening against Kansas.
The Jayhawks enter as 4.5-point favorites, and my Kansas vs. Kentucky prediction backs them to rise up on the road as part of our college basketball picks for Tuesday, Nov. 10.
TOP PICK
Who will win Kansas vs Kentucky: Kansas -4.5
It was speculated that longtime Jayhawks head coach Bill Self debated retirement this offseason, but he ultimately decided to return. That goes to show how much he believes in this team and its ceiling. Self might be feeling like it's 2022 all over again. We've seen just how good the Jayhawks can be early on this season, with Kansas destroying Fordham and Middle Tennessee in its first two games.
On the other side, Kentucky is a mess. Mark Pope's seat gets a little warmer with every close win against teams ranked more than 100 spots below the Wildcats. Kentucky has lost its mojo since spending $22 million on its roster a year ago.
The Wildcats are unbettable until they can prove otherwise. This is a very talented Kansas team, and even as a road favorite, the Jayhawks should be able to tally a two-possession win.
This is playable up to 6.5. I'm also backing Kansas in my college basketball predictions and moneyline picks.
COVERS INTEL: Through just two games, the Jayhawks have faced a far tougher schedule than the Wildcats. Haslametrics shows nearly a 100-spot difference between the two teams in strength of schedule. Plus, Kansas faced Pitt State, Louisville, and Duke in October to prepare for the season. Trust the battle-tested team.
Kansas vs Kentucky Over/Under pick: Under 157.5
Kansas has sped up this season while ranking 120th in pace, and Kentucky sits 27 spots below the Jayhawks. Kansas will make life for this Wildcats offense a living hell. Kentucky is already struggling to get to the line, ranking 319th through two games, while Kansas sits ninth in free-throw rate defense.
Additionally, Kansas hasn't been consistent at the charity stripe, shooting just 53.8% from the line this season, which ranks 345th in the nation.
Given the early tests Kansas has faced, the Jayhawks should be more than ready to shut down this Kentucky offense. I don't see the Wildcats contributing much to the total. This one should stay below 157.5.
Playable down to 152.5.
Kansas vs Kentucky combo
With Kansas suffocating the Wildcats defensively, the Jayhawks should come out on top. Pair Kansas to win with the Under and grab a nice 2.90x payout.
Kansas vs Kentucky combo
- Kansas moneyline
- Under 157.5
- Top picks: 17-8, +8.53 units
Kansas vs Kentucky odds
For help understanding probabilities, see our odds calculator.
- Spread: Kansas -4.5 | Kentucky +4.5
- Over/Under: Over 157.5 | Under 157.5
- Moneyline: Kansas 65% | Kentucky 36%
For the full slate of college basketball matchups, check out our college basketball odds board!
Kansas vs Kentucky trend
The Jayhawks are 4-0-1 against the spread in their last five neutral-site games as a favorite. Find more college basketball betting trends.
How to watch Kansas vs Kentucky
| Location | United Center, Chicago, Ill. |
| Date | Tuesday, Nov. 10, 2026 |
| Tip off | 9:30 p.m. ET |
| TV | ESPN |
Kansas vs Kentucky latest injuries
Check out our college basketball injuries page for updates on every team.
Odds are correct at the time of publishing and are subject to change.
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