College basketball is back, and some big-name programs could be riding the struggle bus tonight.
Our college basketball against-the-spread picks feature 10 games, including Duke vs. Michigan State and Kansas vs. Kentucky.
Check out our latest college basketball picks before the action tips off on Tuesday, Nov. 10.
College basketball against the spread picks: Nov. 10
For help understanding Polymarket probabilities, see our odds calculator.
| Matchup | Pick |
|---|---|
 Florida State Florida |
+9.5 51% |
 Michigan State Duke |
+6.5 50% |
 Iowa  Virginia Tech |
-4.5 53% |
 La Salle Villanova |
+22.5 49% |
 North Carolina Wyoming |
-14.5 50% |
 Wright State Toledo |
-1.5 51% |
 Vanderbilt Memphis |
-15.5 52% |
 Texas Tech Illinois |
+2.5 51% |
 Kansas State Creighton |
+3.5 51% |
 Kentucky Kansas |
+4.5 51% |
Percentages courtesy of Polymarket, one of our best prediction market apps.
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Expert college basketball ATS picks: Nov. 10
Florida State vs Florida (-9.5): +9.5
Florida might be No. 1 in the country, but laying nearly 10 points on the road against an unbeaten rival is a lot to ask. Florida State lost by two last year. I don't see the Seminoles getting taken to the woodshed at home.
Michigan State vs Duke (-6.5): +6.5
Duke might win, but laying 6.5 points against Michigan State on a neutral floor is asking too much. The Spartans can control the glass and make things ugly. This looks like a one- or two-possession game. Give me the points.
Iowa (-4.5) vs Virginia Tech: -4.5
Sioux City is a neutral site only if you ignore all of the Iowa fans in the stands. The Hawkeyes have allowed just 50.5 points per game through two wins. That defense and a friendly crowd could put Virginia Tech on the struggle bus.
La Salle vs Villanova (-22.5): +22.5
Twenty-two and a half points in a Philadelphia Big 5 rivalry? That's a big number. Villanova is already 1-1, and La Salle won't roll over for its city rival. The Wildcats should win, but taking the Explorers to the woodshed is another matter.
North Carolina (-14.5) vs Wyoming: -14.5
Wyoming beat up on Regis and Idaho State. Now comes a serious weight-class jump against North Carolina. The Tar Heels just dropped 109 on Wofford, and their size and depth could be a problem. I like UNC to win comfortably.
Wright State (-1.5) vs Toledo: -1.5
Wright State is 2-0 and just hammered Florida Atlantic by 26 points. Toledo has already lost twice, and the Raiders have enough offense to give the Rockets trouble. With this spread barely above a pick'em, I'm backing Wright State.
Vanderbilt (-15.5) vs Memphis: -15.5
Vanderbilt just thumped Wake Forest, winning 74-51. Now Memphis visits Memorial Gym, where those strange baseline benches can be a problem. If the Commodores get rolling early, this could get ugly. I'll lay the points.
Texas Tech vs Illinois (-2.5): +2.5
Lubbock isn't where you want to go looking for an easy November win. No. 3 Illinois is better on paper, but No. 19 Texas Tech gets the home crowd and 2.5 points. That will be a problem for the Illini.
Kansas State vs Creighton (-3.5): +3.5
Kansas State just buried 17 threes against CSUN, and Bramlage Coliseum gets loud when the Wildcats get rolling. Creighton is 2-0, but this is a tough road trip. In a one-possession game, I'll gladly take the home underdog and the hook.
Kentucky vs Kansas (-4.5): +4.5
No. 15 Kansas looks good, but I'm not laying 4.5 points against No. 24 Kentucky on a neutral floor. Both teams are 2-0, and this feels like a game decided in the final minute. Give me the Wildcats and the points.
Today's college basketball ATS combo
Florida State +9.5
Michigan State +6.5
North Carolina -14.5
Florida State and Michigan State are getting too many points in games that should stay close. Neither team is headed to the woodshed. North Carolina has a serious weight-class advantage over Wyoming and should roll at home. Three solid plays with an attractive payout.
Odds are correct at the time of publishing and are subject to change.
Not intended for use in MA.
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