College Basketball Predictions and Moneyline Picks: Tuesday, Nov. 10

Colby Marchio - Contributor at Covers.com
Colby Marchio • Betting Analyst 7+ years betting experience
Updated: Nov 10, 2026 , 10:49 AM ET • 4 min read

Our college hoops expert sizes up the first Super Tuesday of the year. See why he's leaning on Illinois, Memphis, and more.

College Basketball Predictions and Moneyline Picks, Patrick Ngongba, Andrej Stojakovic, Thomas Haugh
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Do not hold back those tears! Let them out! Today's slate is that beautiful.

College basketball is back, and we have our first true Super Tuesday. There's a lot to get into!

Here are my college basketball moneyline picks, featuring why Illinois should easily take down Texas Tech, along with a variety of chalk favorites and massive underdogs.

Visit our college basketball picks for more matchup analysis.

College basketball moneyline picks: Nov. 10

For help understanding Polymarket probabilities, see our odds calculator.

Matchup Pick
Duke Duke
Michigan State Michigan State
Duke
75%
Florida Florida
Florida State Florida State
Florida
82%
Memphis Memphis
Vanderbilt Vanderbilt
Memphis
9%
Illinois Illinois
Texas Tech Texas Tech
Illinois
58%
Wyoming Wyoming
UNC North Carolina
UNC
91%
Kansas Kansas
Kentucky Kentucky
Kansas
65%
Creighton Creighton
Kansas State Kansas State
Kansas State
43%

Percentages courtesy of Polymarket, one of our best prediction market apps.

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Expert college basketball moneyline picks: Nov. 10

Duke vs Michigan State: Duke Duke

I’m currently sitting with an Under ticket in this ballgame. I think both sides have a great chance of covering the 7-point spread, but Duke boasts far more firepower than this Jeremy Fears Jr.-led Michigan State squad. It could be a long night for ol’ Sparty.

Florida vs Florida State: Florida Florida

I'm currently holding a Florida -9.5 ticket. There's no reason for this fully loaded Gators team to overlook the Seminoles. They don't play anyone of relevance until next Tuesday against Notre Dame. With 11 returning players who know Todd Golden's system, this road game should be a breeze for the Gators.

Memphis vs Vanderbilt: Memphis Memphis

This game could be one of the more interesting matchups of the day. Memphis has gone through a grueling month of preparation for the season, and its first two games haven't been a cakewalk, either. Over the last month, the Tigers have faced Mississippi State, Arkansas, Iowa State, and VCU.

Vanderbilt hasn't faced nearly as many tests out of the gate, but the Commodores are the better team. However, the Tigers are being disrespected here. Give me the heavy dog!

Illinois vs Texas Tech: Illinois Illinois

Texas Tech returns just one starter from last season, while Illinois brings back its key pieces from a Final Four run. The Illini have coasted through their first two games, scoring 110-plus points in both.

Wyoming vs North Carolina: UNC North Carolina

This is more of a radar game for us, as Georgia coasted last night against FGCU, clearly looking ahead to this matchup with the Tar Heels. If North Carolina dominates, we can circle the Bulldogs on Friday in Chapel Hill.

The Tar Heels should roll here without a doubt. This is the first team Oklahoma State has faced outside the 300s.

Kansas vs Kentucky: Kansas Kansas

Kansas head coach Bill Self may have retired this past offseason if he didn't believe this was a championship-contending team. That should speak volumes about the talent on this roster.

On the other side, when can we truly trust Kentucky again? The Wildcats let James Madison hang around last week. Fade Mark Pope until he gives us a reason not to this campaign.

Creighton vs Kansas State: Kansas State Kansas State

Kansas State is coming off its first win after opening the season with a loss to South Dakota State.

It's hard to trust this new Bluejays team, especially after opening the season against two teams ranked in the 300s. With the Wildcats having nothing to look ahead to now, I like them at home.

Charleston Southern vs Wake Forest: Wake Forest Wake Forest

Following their brutal loss to Vanderbilt, Wake Forest should be geared up and ready to get back on track with a blowout win over a bottom-50 team. There's nothing to distract Wake Forest now, so the Demon Deacons should have no problem covering the 19-point spread.

Virginia Tech vs Iowa: Virginia Tech Virginia Tech

If Virginia Tech can speed up the game instead of letting Iowa dictate a turtle-like pace, the Hokies should be able to come out on top. They've struggled with fouling, but if they continue playing elite defense and forcing turnovers, the Hokies can pull off the road win.

Green Bay vs Northern Iowa: Green Bay Green Bay

With Doug Gottlieb finally putting all his energy into one full-time job, Green Bay is starting to play some solid basketball. The Phoenix have already faced tougher tests early on, and Northern Iowa's defense is questionable. Give me the dog!

Today's college basketball moneyline combo

Polymarket

Florida

Illinois

Kansas

Three of my favorite teams are on the board today. All three are sitting on my Tuesday card to either secure the win or cover. They have the talent, and nothing to look ahead to next. Their focus is on right now.

Odds are correct at the time of publishing and are subject to change.
Not intended for use in MA.
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Colby Marchio
Betting Analyst

Colby Marchio is a two-time DePaul alum and former Division 1 (club) baseball player who has been sports betting since 2019. Since graduating in 2021, he has worked throughout the media circuit, hosting and appearing on various television and radio shows while making countless guest appearances discussing Major League Baseball, college basketball, college football, and the National Football League.

A self-proclaimed numbers nerd, Colby may enjoy digging through the data even more than winning itself. That passion is why his two favorite sports to cover are college basketball and Major League Baseball. 

As for his favorite sportsbook, it is whichever one has the best price, or whichever one is not taxing him as an Illinois resident. 

You can find all of his plays and more @ColbyMBets on Twitter/X.

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