At this point in the schedule, every game is a “big” game in the Big East.
The Villanova Wildcats need their big man in the middle, Duke Brennan, to rise to occasion against the Butler Bulldogs tonight, with the Wildcats chasing a Top 3 seed in the upcoming conference tournament.
My Butler vs. Villanova predictions and college basketball picks bank on Brennan to beat up the Bulldogs inside.
Butler vs Villanova prediction
Butler vs Villanova best bet: Duke Brennan Over 11.5 points (-125)
Duke Brennan managed just seven points against a beefy UConn team last time, but will throw his size around against the Butler Bulldogs' frontcourt.
The Bulldogs allow the third-most points in the paint in Big East competition and had a tough time with the Wildcats’ 6-foot-10 senior in their first meeting, with Brennan tallying 15 points.
He does the bulk of his damage in the key, scoring eight of his 12 PPG in the paint. Butler is weak on the glass, allowing many offensive rebounds. Brennan battles hard for extra possessions, pulling in 3.6 ORPG.
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Butler vs Villanova same-game parlay
Butler hasn’t been great on the road, going 2-7 SU and 4-5 ATS as a true visitor. Game projections call for a Wildcats win between 10 and 12 points Wednesday night.
The Villanova Wildcats are 9-6 Over/Under at home and topped the 149-point total when these Big East teams battled at Butler in January.
Brennan beat up Butler for 15 points in their first matchup. He bounces back from a long day versus UConn with a strong showing against the Bulldogs’ soft interior.
Butler vs Villanova SGP
- Duke Brennan Over 11.5 points
- Villanova -9.5
- Over 146.5
Our beyond the arc SGP: Raining cats and dogs
Brennan snatched 10 rebounds vs. Butler last time, and models call for 11-plus.
Butler vs Villanova SGP
- Villanova -9.5
- Over 146.5
- Duke Brennan Over 11.5 points
- Duke Brennan Over 10.5 rebounds
Butler vs Villanova odds
- Spread: Butler +9.5 | Villanova -9.5
- Moneyline: Butler +400 | Villanova -550
- Over/Under: Over 146.5 | Under 146.5
Butler vs Villanova betting trend to know
Villanova has gone Over the total in 11 of its last 14 games (+7.70 Units / 50% ROI). Find more college basketball betting trends for Butler vs. Villanova.
How to watch Butler vs Villanova
| Location | Finneran Pavilion, Villanova, PA |
| Date | Wednesday, February 25, 2026 |
| Tip-off | 7:00 p.m. ET |
| TV | FS1 |
Butler vs Villanova key injuries
Odds are correct at the time of publishing and are subject to change.
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