The Cleveland Cavaliers hit the road tonight for the tail-end of a back-to-back against the Detroit Pistons at Little Caesars Arena.
Cleveland won three out of four against Detroit last season, and my Cavaliers vs Pistons predictions are eyeing them to grab another victory here.
Read more for my NBA picks for Monday, October 27.
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Cavaliers vs Pistons prediction
Cavaliers vs Pistons best bet: Cavaliers -2.5 (-110)
The Cleveland Cavaliers are coming off a dominant 64-win season, and have started this season on the right foot, going 2-1 through three games, most recently toppling Giannis Antetokounmpo and the Milwaukee Bucks in Sunday's home opener. Cleveland heads into tonight’s affair as a 2.5-point favorite, which shouldn’t be hard to cover.
Firstly, the Cavs were 3-1 against the Detroit Pistons in 2024-25, covering the spread in two of those victories, and Kenny Atkinson’s squad has won 12 of its last 13 vs. the Pistons. While Detroit has improved, this is still a team that Cleveland has completely dominated over the years.
It’s just the fourth game for the Cavs, and they're back on the road, so there’s not a ton of evidence here. But, between their brilliance against Detroit and the impressive win over the Bucks, I’ll take them to win by at least three points tonight.
Cavaliers vs Pistons same-game parlay
De'Andre Hunter was the Cavs’ top bench player last season, averaging 17 points per game. He poured in 16 points in his season debut, and he also scored Over 15.5 points in two of his three preseason appearances.
Jalen Duren is a physical presence down low, and he was key in getting the Pistons to the playoffs last season. The big man averaged 10.3 rebounds per game.
After grabbing just six boards in each of his first two games this season, Duren reeled in 18 on Sunday against the Celtics. He also averaged 11.5 rebounds against the Cavs last season.
Cavaliers vs Pistons SGP
- Cavaliers -2.5
- De'Andre Hunter Over 15.5 points
- Jalen Duren Over 10.5 rebounds
Our "from downtown" SGP: Cavs cover Cade
Cade Cunningham has cashed the Over in dimes in two of his three appearances this season, but he’s up against a solid Cavs defense. He also averaged only 7.3 dimes in ‘24-25 versus Cleveland.
Cavaliers vs Pistons SGP
- Cavaliers -2.5
- De'Andre Hunter Over 15.5 points
- Jalen Duren Over 10.5 rebounds
- Cade Cunningham Under 8.5 assists
Cavaliers vs Pistons odds
- Spread: Cavaliers -2.5 (-115) | Pistons +2.5 (-105)
- Moneyline: Cavaliers -150 | Pistons +125
- Over/Under: Over 231.5 (-110) | Under 231.5 (-110)
Cavaliers vs Pistons betting trend to know
The Cleveland Cavaliers have hit the Moneyline in 68 of their last 91 games (+13.85 Units / 3% ROI). Find more NBA betting trends for Cavaliers vs. Pistons.
How to watch Cavaliers vs Pistons
| Location | Little Caesars Arena, Detroit, MI |
| Date | Monday, October 27, 2025 |
| Tip-off | 7:00 p.m. ET |
| TV | Peacock |
Cavaliers vs Pistons latest injuries
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