The Chicago White Sox are playing their best ball heading into a series with their crosstown rivals, winning five in a row by an aggregate score of 26-14.
My Cubs vs. White Sox predictions expect the home team to give the Cubs all they can handle in Game 1.
Let's take a closer look at my MLB picks for Friday, May 15.
Who will win Cubs vs White Sox today: White Sox +1.5 (-135)
All arrows are pointing upwards for the Chicago White Sox, who have won five consecutive games and posted strong indicators in May.
The White Sox rank fourth in wOBA, second in ISO, and second in hard hit rate against right-handed pitching this month – ahead of their North Side counterparts in each category.
Pitching has also been a strength. Sean Burke will be backed by a bullpen that owns a clean 1.00 WHIP and sits seventh in xFIP in May.
With everything coming together, it's easy to see how the ChiSox have covered +1.5 in 14 of 16. Expect that trend to continue.
COVERS INTEL: The White Sox lead the league in HR/FB against righties in May.
Cubs vs White Sox Over/Under pick: Under 8.5 (-115)
Burke has allowed two runs or fewer in five of his past six starts. He's walking few batters and limiting hard contact, which is a good recipe for success.
With a strong, in-form bullpen backing him up, the White Sox should limit a Chicago Cubs offense that has scored five runs over the past five games.
Edward Cabrera is sporting a 33.1 FB% this season. His ability to keep the ball on the ground equips him to slow down a White Sox team that sits fifth in homers and is more reliant on the longball than stringing together hits.
- ML/RL bets: 17-7, +7.28 units
- Over/Under bets: 10-13-1, -4.11 units
Cubs vs White Sox odds
- Moneyline: Cubs -145 | White Sox +125
- Run line: Cubs -1.5 (+115) | White Sox +1.5 (-135)
- Over/Under: Over 8.5 (-105) | Under 8.5 (-115)
Cubs vs White Sox trend
The Cubs have hit the Under in six straight games. Find more MLB betting trends for Cubs vs. White Sox.
How to watch Cubs vs White Sox and game info
| Location | Guaranteed Rate Field, Chicago, IL |
| Date | Friday, May 15, 2026 |
| First pitch | 7:40 p.m. ET |
| TV | Marquee, CHSN |
| Cubs starting pitcher | Edward Cabrera (3-1, 3.89 ERA) |
| White Sox starting pitcher | Sean Burke (2-3, 3.68 ERA) |
Cubs vs White Sox latest injuries
Cubs vs White Sox weather
Odds are correct at the time of publishing and are subject to change.
Not intended for use in MA.
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