The Philadelphia 76ers suffered a blowout home loss to the Cleveland Cavaliers on Wednesday, but they’ll look to get back in the win column with Friday’s rematch in Philly.
Tyrese Maxey is one of the NBA’s top scorers, and my Cavaliers vs. 76ers predictions expect him to bounce back on offense after a dud on Wednesday.
Here are my best free NBA picks for Friday’s Eastern Conference matchup at Xfinity Mobile Arena on Friday, January 16.
Cavaliers vs 76ers prediction
Cavaliers vs 76ers best bet: Tyrese Maxey Over 25.5 points (-120)
Tyrese Maxey is scoring a career-high 30.5 points per game this season, and tonight's scoring line is set at a juicy 25.5 points. He finished with just 14 points on 5-of-16 shooting in Wednesday's win, but he posted 26+ in three straight and nine of 10 games before that.
Maxey has scored at least 26 in 29 of 37 games overall, including 13 of 19 at home. He’s reached the Over on this scoring line in 78.3% of his games, meaning the odds here should be -360. I’ll gladly take the discount here.
Maxey’s 14 points in his last game out represent his third-lowest scoring total of the season. He scored 27 in his other matchup with the Cleveland Cavaliers this season, and he scored 27 and 29 in two matchups with the Cavs last season.
Cleveland will be missing Darius Garland and Sam Merrill tonight, and the Philadelphia 76ers should be close to full strength. I expect a more competitive showing and a bounce-back performance for the Sixers’ electric leading scorer.
Cavaliers vs 76ers same-game parlay
Jaylon Tyson finished with 20, 17, and 27 PRA across 25.3 minutes over his last three games. He started Wednesday in place of Sam Merrill, who was injured in that contest.
Merrill and Darius Garland are both out tonight, which should mean another start for Tyson. He's averaged 21 PRA across 22 started, hitting the Over on this line 13 times, including five of eight on the road.
The 76ers have hit the Over in nine of 13 games as the home favorite. Cleveland is 11-7 to the Over on the road.
The teams are 9-1 to the Over across their last 10 head-to-head matchups.
Cavaliers vs 76ers SGP
- Tyrese Maxey Over 25.5 points
- Jaylon Tyson Over 21.5 points + rebounds + assists
- Over 235
Our "from downtown" SGP: Spida web
Donovan Mitchell has scored at least 31 points in nine of 16 road games this season, and has dropped point totals of 35 and 46 against the 76ers.
Cavaliers vs 76ers SGP
- Tyrese Maxey Over 25.5 points
- Jaylon Tyson Over 21.5 points + rebounds + assists
- Over 235
- Donovan Mitchell Over 30.5 points
Cavaliers vs 76ers odds
- Spread: Cleveland +1.5 (-105) | Philadelphia -1.5 (-115)
- Moneyline: Cleveland +110 | Philadelphia -130
- Over/Under: Over 235 (-110) | Under 235 (-110)
Cavaliers vs 76ers betting trend to know
The Cavaliers have hit the 1Q Over in 29 of their last 45 away games (+11.35 Units / 22% ROI). Find more NBA betting trends for Cavaliers vs. 76ers.
How to watch Cavaliers vs 76ers
| Location | Xfinity Mobile Arena, Philadelphia, PA |
| Date | Friday, January 16, 2026 |
| Tip-off | 7:00 p.m. ET |
| TV | ESPN |
Cavaliers vs 76ers latest injuries
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