The New York Yankees and San Francisco Giants hit Oracle Park to begin the 2026 season Wednesday, March 25, and I’ve a pair of home run MLB picks for the opener.
My top Yankees vs. Giants predictions call for New York superstar Jazz Chisholm and San Fran shortstop Willy Adames to leave the yard tonight.
Yankees vs Giants home run picks for March 25
Jazz Chisholm
Willy AdamesYankees home run pick
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Jazz Chisholm (+800)
New York Yankees second baseman Jazz Chisholm posted an impressive .360 wOBA and .267 ISO against righties last season, in addition to 26 of his 31 home runs coming against right-handed arms.
While Chisholm is just 3-for-13 and without an extra-base hit against San Francisco Giants starter Logan Webb, that’s overpriced into these long odds.
Giants home run pick
Willy Adames (+600)
San Francisco Giants shortstop Willy Adames hit 10 of his 30 homers with a rock-solid .226 ISO against left-handed pitchers last season, and he’s also gone 2-for-6 with a pair of doubles against New York Yankees starter Max Fried.
How to watch Yankees vs Giants and game info
| Location | Oracle Park, San Francisco, CA |
| Date | Wednesday, March 25, 2026 |
| First pitch | 8:05 p.m. ET |
| TV | Netflix |
Odds are correct at the time of publishing and are subject to change.
Not intended for use in MA.
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