Red Sox vs Phillies Prediction, Picks & Odds — Monday, July 21

Our Red Sox vs. Phillies predictions expect Kyle Schwarber and Zack Wheeler to lead the way for Philly.

Neil Parker - Analyst at Covers.com
Neil Parker • Betting Analyst
Jul 21, 2025 • 11:31 ET • 4 min read

MLB

Match starts: 2 hrs
PHI
68 %
BOS
32 %
EXPERT PICK - PROP
Kyle Schwarber o1.5  Hits, Runs, and RBIs (-120) Kyle Schwarber o1.5 Hits, Runs, and RBIs (-120)
Read Analysis
Kyle Schwarber Philadelphia Phillies MLB
Photo By - Imagn Images. Kyle Schwarber celebrates after hitting a grand slam against the Angels.

The Boston Red Sox head to Citizens Bank Park to start a three-game set against the Philadelphia Phillies on Monday, July 21.

Philly has rolling righty Zack Wheeler toeing the rubber, and my Red Sox vs. Phillies predictions and top MLB picks expect him and teammate Kyle Schwarber to do the heavy lifting tonight.

Caesars QuickPick: Our Red Sox vs Phillies same-game parlay (SGP)

Phillies moneyline

Kyle Schwarber Over 1.5 hits + runs + RBI

Roman Anthony Over 1.5 hits + runs + RBI

Red Sox vs Phillies prediction

My Red Sox vs Phillies best bet: Kyle Schwarber Over 1.5 hits + runs + RBI (-125 at Caesars)

Red Sox vs Phillies best bet analysis

Philadelphia Phillies masher Kyle Schwarber has teed off on righties to the tune of a .366 wOBA, .265 ISO, and .855 OPS, and he’s up to 70 runs, 91 hits, and 74 RBI for the campaign. 

This should prove to be a favorable pitching matchup, too. Boston Red Sox righty Walker Buehler has surrendered a .324 batting average and .386 wOBA to left-handed hitters, after all. 

Of course, Schwarber has also hit the Over in this market in nine of 14 July games while posting a monster 1.068 OPS.

Hitting at the top of the Philly lineup has also been a huge boost for his counting stats. The three-time All-Star has hit in the two-hole in 33 of his past 34 games and filled out the box score with 25 runs, 31 hits, and 28 RBI during the stretch.

Schwarber has also posted a monster .407 wOBA, .328 ISO, and .962 OPS during the heater.

Red Sox vs Phillies same-game parlay analysis

The Phillies have a huge pitching advantage in tonight’s tilt, with Zack Wheeler taking a sterling 2.36 ERA, 0.86 WHIP, and 2.62 xFIP to the bump as the betting favorite in the NL Cy Young odds.

It’s been a different story for Red Sox righty Walker Buehler, sporting respective 6.12, 1.56, and 4.72 marks.

Turning to the final leg of this SGP, Red Sox rookie Roman Anthony has had his way with right-handed pitchers. So, while Wheeler is a daunting matchup, I still like Anthony to fill up the box score.

The rookie sports a .387 wOBA, .173 ISO, and .873 OPS against right-handed arms for the campaign, after all.

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Red Sox vs Phillies odds

Red Sox vs Phillies live odds

Red Sox vs Phillies opening odds

  • Moneyline: Boston +175 | Philadelphia -210
  • Run line: Boston +1.5 (-115) | Philadelphia -1.5 (-105)
  • Over/Under: Over 8.5 | Under 8.5

Odds courtesy of Caesars.

Red Sox vs Phillies trend

The Phillies have covered the run line in 18 of their last 32 games (+5.10 units / 14% ROI). Find more MLB betting trends for Red Sox vs. Phillies.

How to watch Red Sox vs Phillies and game info

Location Citizens Bank Park, Philadelphia, PA
Date Monday, 7-21-2025
First pitch 6:45 p.m. ET
TV NESN, NBCS-Philadelphia
Red Sox starting pitcher Walker Buehler
(6-6, 6.12 ERA)
Phillies starting pitcher Zack Wheeler
(9-3, 2.36 ERA)

Red Sox vs Phillies latest injuries

Red Sox vs Phillies weather

Odds are correct at the time of publishing and are subject to change.
Not intended for use in MA.
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Neil Parker - Covers
Betting Analyst

Neil Parker is, first and foremost, a sports fan. A huge supporter of the Cowboys, Cubs, and Maple Leafs, he has managed to parlay his passion into writing gigs at some of the top websites in the industry.

Neil takes a numbers-based approach to his handicapping and complements his in-depth statistical analysis with a keen eye on the markets to provide the best available odds. He loves to lean on his rolodex of idioms to offset his inner nerd. When it comes to wagering, he throws down on anything that catches his eye at bet365, Betway and BetVictor. He also keeps a close eye on CoolBet because the polar bear brand often has outlier NHL and NFL moneyline prices.

Neil graduated with honors from St. Thomas University in 2007 before completing his BEd at Acadia University in 2010. After teaching a myriad of courses and subjects, he found a groove delivering fun lessons to exceptional learners in non-traditional classroom environments. If his decade-plus teaching run taught him anything about sports betting, it’s to stay the course and use the summer – or offseason – to refresh and prepare to be better in the year to come.

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