The Chicago Cubs will look to improve their winning streak to three games when they host the Pittsburgh Pirates in an NL Central clash at Wrigley Field on Friday, April 10.
My top Pirates vs. Cubs predictions and MLB picks expect Chicago to pull off the victory, with the total going Over the number this afternoon.
Who will win Pirates vs Cubs today: Cubs moneyline (-140)
The Chicago Cubs will receive a boost with Seiya Suzuki making his season debut this afternoon, and the Cubbies have also been on the unlucky side to start the year.
Chicago ranks second in hard-hit rate and sixth in barrel percentage, so positive regression to a 25th-ranked BABIP is coming.
Additionally, Pittsburgh Pirates righty Carmen Mlodzinski has surrendered a 68.0% hard-hit rate through two starts, and three of his five offerings have negative pitch values.
Chicago starter Shota Imanga is also eyeing statistical correction with his 4.50 ERA above his 3.03 xERA and 3.48 xFIP.
COVERS INTEL: Seiya Suzuki was third in wOBA on the Cubs in 2025, and he posted a monster .467 mark during his five-game rehab stint.
Pirates vs Cubs Over/Under pick: Over 6.5 (-113)
The wind is forecasted to be blowing in at the Friendly Confines, but Chicago isn’t truly going to live up to its Windy City moniker.
As noted, the Cubs are positioned to have a breakout day at the dish, and have scored 24 runs across their past four games.
And, while Imanga has solid underlying numbers, the Pirates can also do damage.
Pittsburgh has a deeper and more potent lineup than in years past and ranks seventh in wOBA against lefties to start the season.
- ML/RL bets: 3-4, -0.99 units
- Over/Under bets: 1-2, -1.2 units
Pirates vs Cubs odds
- Moneyline: Pirates +133 | Cubs -138
- Run line: Pirates +1.5 (-156) | Cubs -1.5 (+150)
- Over/Under: Over 6.5 (-113) | Under 6.5 (+108)
Pirates vs Cubs trend
The Cubs have covered the run line in 10 of their last 14 games at home (+7.25 Units / 43% ROI). Find more MLB betting trends for Pirates vs. Cubs.
How to watch Pirates vs Cubs and game info
| Location | Wrigley Field, Chicago, IL |
| Date | Friday, April 10, 2026 |
| First pitch | 2:20 p.m. ET |
| TV | SportsNet Pittsburgh, Marquee |
| Pirates starting pitcher | Carmen Mlodzinski (0-0, 4.00 ERA) |
| Cubs starting pitcher | Shota Imanaga (0-1, 4.50 ERA) |
Pirates vs Cubs latest injuries
Pirates vs Cubs weather
Odds are correct at the time of publishing and are subject to change.
Not intended for use in MA.
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