The San Diego Padres visit the San Francisco Giants for a three-game NL West showdown at Oracle Park beginning Monday, May 4.
My top Padres vs. Giants predictions and MLB picks are calling for San Fran to lose a seventh consecutive game tonight.
Who will win Padres vs Giants today: Padres moneyline (-130)
The San Francisco Giants are last in baseball in wOBA against right-handed pitchers and are turning to Trevor McDonald for his first start of the season Monday.
McDonald sports a worrisome 5.40 ERA and 6.24 xFIP across 15 minor-league innings with Triple A Sacramento, while the San Diego Padres have sneaky righty Randy Vasquez on the bump.
While Vasquez has had some hiccups, it’s hard to argue with his 2.94 ERA and 3.76 xFIP while holding opponents to a .665 OPS through six starts.
COVERS INTEL: A large part of San Diego Padres starter Randy Vasquez’s early success is his 12.4 swinging-strike percentage checking in miles above his 6.7% mark from 2025.
Padres vs Giants Over/Under pick: Under 8.5 (-132)
The Giants aren’t the only team struggling against righties, with the Friars ranking 22nd in wOBA and also playing to the Under in 29 of their past 50 road games (+7.35 Units / 13% ROI).
Additionally, San Fran has only scored 2.5 runs per game while losing eight of its past 10, and San Diego has scored just 2.6 per during its active 4-1 slump.
- ML/RL bets: 17-9, +9.23 units
- Over/Under bets: 9-6, +2.33 units
Padres vs Giants odds
- Moneyline: Padres -135 | Giants +115
- Run line: Padres -1.5 (+120) | Giants +1.5 (-140)
- Over/Under: Over 8 (-110) | Under 8 (-110)
Padres vs Giants trend
The Padres have won 31 of their last 50 games (+8.85 Units / 13% ROI). Find more MLB betting trends for Padres vs. Giants.
How to watch Padres vs Giants and game info
| Location | Oracle Park, San Francisco, CA |
| Date | Monday, May 4, 2026 |
| First pitch | 9:45 p.m. ET |
| TV | Padres.TV, NBC Sports Bay Area |
| Padres starting pitcher | Randy Vasquez (3-0, 2.94 ERA) |
| Giants starting pitcher | Trevor McDonald (0-0, 0.00 ERA) |
Padres vs Giants latest injuries
Padres vs Giants weather
Odds are correct at the time of publishing and are subject to change.
Not intended for use in MA.
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