The Seattle Mariners won the first two games of the series, outscoring the Houston Astros 13-3 in aggregate.
My Mariners vs. Astros predictions see the road team picking up its third consecutive win tonight.
Let's take a closer look at my MLB picks for May 13.
Who will win Mariners vs Astros today: Seattle Mariners (-125)
The Houston Astros are struggling mightily to score runs without several key bats in their lineup. That's even more problematic with Lance McCullers Jr. on the mound.
He has allowed at least three earned runs in six of seven starts this season, and lasted more than five innings just once over his last six.
Excluding Bottom-10 teams in batting average vs. right-handed pitching, McCullers Jr. has allowed three or more runs in all five games, and an average of 4.8.
The Seattle Mariners are well-positioned to score, and they shouldn't need many runs to win against this Houston offense.
COVERS INTEL: Lance McCullers Jr. ranks in the 10th percentile in hard-hit rate allowed.
Mariners vs Astros Over/Under pick: Under 9 (+100)
The Astros have scored three runs or fewer in eight of their last nine games. Worse yet, they have plated just four runs over the last four. Four!
It's not going to get any easier for them against Bryce Miller, who performed well in his rehab starts, and a Mariners bullpen that sits fourth in ERA and eighth in xFIP this season.
The Astros are unlikely to score more than two or three runs, which means the Mariners would have to put forth a ceiling performance to push this game Over the number.
- ML/RL bets: 17-6, +8.53 units
- Over/Under bets: 9-13-1, -5.11 units
Mariners vs Astros odds
- Moneyline: Mariners -125 | Astros +105
- Run line: Mariners -1.5 (+125) | Astros +1.5 (-145)
- Over/Under: Over 9.0 (-115) | Under 9.0 (-105)
Mariners vs Astros trend
The Seattle Mariners have hit the game total Under in 13 of the last 21 away games (+5.5 units, 24% ROI). Find more MLB betting trends for Mariners vs. Astros.
How to watch Mariners vs Astros and game info
| Location | Daikin Park, Houston, TX |
| Date | Wednesday, May 13, 2026 |
| First pitch | 8:10 p.m. ET |
| TV | Mariners.TV, Space City Home Network |
| Mariners starting pitcher | Bryce Miller (4-6, 5.68 ERA) 2025 stats |
| Astros starting pitcher | Lance McCullers Jr. (2-3, 7.41 ERA) |
Mariners vs Astros latest injuries
Mariners vs Astros weather
Odds are correct at the time of publishing and are subject to change.
Not intended for use in MA.
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