The New York Yankees are favored again at home, but this number looks too heavy with Aaron Judge expected out of the lineup.
Gerrit Cole has been excellent in two starts back from elbow surgery, but the Cleveland Guardians bring a contact-heavy approach that will make him work. Gavin Williams’ recent form also gives Cleveland enough pitching upside to justify the plus-money shot.
Here are my Guardians vs Yankees predictions and MLB picks for Wednesday, June 3.
Who will win Guardians vs Yankees today: Guardians ML (+135)
I’m backing the Cleveland Guardians moneyline and would play it to +120.
This is the same matchup idea I used last night against Cam Schlittler: New York is lining up another arm whose success leans on chase, command, and swing-and-miss.
Gerrit Cole has opened with just over 12 scoreless innings, but that level is not sustainable while he rebuilds after elbow surgery.
Again, Cleveland has the second-lowest whiff rate at 22.9% and rarely chases, so the Guardians can again put balls in play, lengthen at-bats, and make a taxed favorite uncomfortable.
COVERS INTEL: Cleveland’s lineup has four projected hitters with strikeout rates of 13% or lower: Jose Ramirez, Chase DeLauter, Brayan Rocchio, and David Fry.
Guardians vs Yankees Over/Under pick: Under 7 (+102)
Cole is still Cole, and even though the Guardians will make him labor, this is still a guy who has allowed zero barrels since returning, with a 2.19 expected ERA. Cleveland’s contact profile is more annoying than explosive, after all, last night was the first time they scored more than four runs in 13 games.
- ML/RL bets: 26-21, +4.59 units
- Over/Under bets: 30-17, +15.07 units
Guardians vs Yankees odds
- Moneyline: Guardians +135 | Yankees -160
- Run line: Guardians +1.5 | Yankees -1.5
- Over/Under: Over 7 | Under 7
Guardians vs Yankees trend
The New York Yankees have hit the Moneyline in 12 of their last 17 games at home (+3.70 Units / 13% ROI). Find more MLB betting trends for Guardians vs. Yankees.
How to watch Guardians vs Yankees and game info
| Location | Yankee Stadium, Bronx, NY |
| Date | Wednesday, June 3, 2026 |
| First pitch | 7:05 p.m. ET |
| TV | YES Network, CLEGuardians.TV |
| Guardians starting pitcher | Gavin Williams (8-3, 3.07 ERA) |
| Yankees starting pitcher | Gerrit Cole (1-0, 0.00 ERA) |
Guardians vs Yankees latest injuries
Guardians vs Yankees weather
Odds are correct at the time of publishing and are subject to change.
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