The San Francisco Giants finally saw their bats break out in a 9-3 win over the San Diego Padres, and now they’ll go for the sweep.
That will be easier said than done, however, as the Padres hand the ball to Nick Pivetta, who's dominated this Giants lineup.
My Giants vs. Padres predictions and MLB picks explain why Pivetta will lead San Diego to a win in the series finale.
Who will win Giants vs Padres today: Padres moneyline (-150)
Even with the San Francisco Giants' bats breaking out last night, this hasn’t exactly graded out as a potent lineup.
They enter tonight’s game against Nick Pivetta and the San Diego Padres ranked 26th in wRC+ and OPS through the early portion of the season.
Which means the Giants won’t be looking forward to this matchup with Pivetta. The right-hander has dominated this lineup, limiting current Giants hitters to a .202 expected batting average and a .388 expected slugging with a 31.1% strikeout rate.
With journeyman Adrian Houser going for San Francisco, I like the Padres to get the win.
COVERS INTEL: Nick Pivetta allowed two earned runs and struck out 15 in his last two starts against the Giants.
Giants vs Padres Over/Under pick: Under 7.5 (+100)
The Giants' lineup isn’t the only one struggling in this matchup, however. The Padres have been ice-cold to start the season, ranking dead last in both wRC+ and OPS through their first five games of the season.
Houser isn’t going to blow anyone away, but he’s coming off a season where he pitched to a solid 3.31 ERA. Plus, he’s got some decent backup with the Giants’ bullpen ranking sixth in xFIP.
Pitching will be the story. Take the Under.
- ML/RL bets: 0-0, +0.0 units
- Over/Under bets: 0-0, +0.0 units
Giants vs Padres odds
- Moneyline: San Francisco +125 | San Diego -150
- Run line: San Francisco +1.5 (-170) | San Diego -1.5 (+145)
- Over/Under: Over 7.5 | Under 7.5
Giants vs Padres trend
The Padres have only cashed the Over in 64 of their last 153 games for -31.45 units and a -19% ROI. Find more MLB betting trends for Giants vs. Padres.
How to watch Giants vs Padres and game info
| Location | Stadium, City, State/Province |
| Date | Wednesday, April 1, 2026 |
| First pitch | 4:10 p.m. ET |
| TV | NBCS-Bay Area, Padres.TV |
| Giants starting pitcher | Adriand Houser (0-0, 0.00 ERA) |
| Padres starting pitcher | Nick Pivetta (0-1, 18.00 ERA) |
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Odds are correct at the time of publishing and are subject to change.
Not intended for use in MA.
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