The San Francisco Giants head east for a three-game weekend series with the Baltimore Orioles.
Friday’s series opener sees Landen Roupp get the nod for the visitors and Shane Baz take the bump for the home team.
See why I’m backing the hosts in my Giants vs. Orioles predictions and MLB picks for April 10.
Who will win Giants vs Orioles today: Orioles (-125)
The Baltimore Orioles have an edge in starting pitching, the bullpen, and hitting, so I’m backing the home team as a slight favorite against the San Francisco Giants tonight.
San Francisco has been the worst team in the league against RHP (61 wRC+), and Baltimore has been slightly above average (104). The Orioles bullpen has posted a 3.94 FIP, compared to 4.47 for the Giants.
Baltimore right-hander Shane Baz’s velocity is up half a tick, and his 104 Stuff+ is encouraging, while San Francisco starter Landen Roupp has struggled with walks (3.97 per nine innings) and allowed seven runs to the Mets in his previous start.
COVERS INTEL: These Giants hitters have 17 career at-bats against Baz, during which they’ve managed just two hits while striking out seven times.
Giants vs Orioles Over/Under pick: Under 8.5 (-110)
These are two quality starting pitchers, as Roupp owns a 1.37 FIP, while Baz isn’t far behind at 2.88.
San Francisco has been miserable at the plate and now has to travel across the country and face a tough opponent. It doesn’t project as a breakout spot.
Baltimore has been on a prolonged Under stretch, going 13-22 O/U in its last 35 games dating back to last season.
- ML/RL bets: 3-3, +0.25 units
- Over/Under bets: 3-4, -1.16 units
Giants vs Orioles odds
- Moneyline: Giants +105 | Orioles -125
- Run line: Giants +1.5 (-200) | Orioles -1.5 (+165)
- Over/Under: Over 8.5 (-110) | Under 8.5 (-110)
Giants vs Orioles trend
The Giants have lost 18 of their last 30 games. Find more MLB betting trends for Giants vs. Orioles.
How to watch Giants vs Orioles and game info
| Location | Oriole Park at Camden Yards, Baltimore, MD |
| Date | Friday, April 10, 2026 |
| First pitch | 7:15 p.m. ET |
| TV | Apple TV |
| Giants starting pitcher | Landen Roupp (1-1, 4.22 ERA) |
| Orioles starting pitcher | Shane Baz (0-0, 4.09 ERA) |
Giants vs Orioles latest injuries
Giants vs Orioles weather
Odds are correct at the time of publishing and are subject to change.
Not intended for use in MA.
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