After swapping first place in the NL West over the first two games, the Los Angeles Dodgers and San Diego Padres play the rubber match of their series in San Diego. The Dodgers are up by half a game and will send Shohei Ohtani to the mound.
The Padres counter with Randy Vasquez, who is having a breakout year but may not match up well. My Dodgers vs. Padres predictions and MLB picks call for the Dodgers to tighten their hold on first place with a win.
Who will win Dodgers vs Padres today: Dodgers -1.5 (+100)
The Los Angeles Dodgers have their Cy Young candidate set to throw. Shohei Ohtani is in the Top 2% in pitching, fastball, and breaking ball value and has an ERA and WHIP below 1.00.
He's also back in the lineup after being held out in recent starts. He’s 10 for his last 19 with 21 total bases and 10 RBI.
The San Diego Padres start Randy Vasquez (5-1, 2.68 ERA), with career-best rates in several statistics. His swing and misses are up, but he’s allowing solid contact more often than in past seasons, a danger against this L.A. lineup.
COVERS INTEL: Randy Vasquez has added more than a mph to his fastball and sinker velocities, and opponents haven’t caught up. Still, they’re hitting .364 against his cutter and .300 against his curve, both up significantly from last year. Plus, the Dodgers have four batters (Ohtani, Hernandez, Muncy, Tucker) in MLB’s Top 40 against either the sinker or four-seamer.
Dodgers vs Padres Over/Under pick: Over 7.5 (+100)
Vasquez is getting batters to swing and miss, but when they make contact, they drive the ball. He’s in MLB’s bottom quartile in average exit velocity allowed, as well as hard-hit and barrel rate.
The Dodgers have four batters in MLB’s Top 40 in barrel rate, four in the Top 50 in hard-hit percentage, and three in the Top 40 in average exit velo. Blowing it past them seems like a shaky prospect.
Ohtani has been lights out on the mound for the Dodgers this year, but L.A. used five relievers for 66 total pitches on Tuesday. San Diego’s pen is even more fatigued after they used five for 78 pitches.
- ML/RL bets: 14-19, -4.33 units
- Over/Under bets: 18-19, -2.51 units
Dodgers vs Padres odds
- Moneyline: Dodgers -163 | Padres +156
- Run line: Dodgers -1.5 (+105) | Padres +1.5 (-125)
- Over/Under: Over 7.5 (-102) | Under 7.5 (-118)
Dodgers vs Padres trend
The Dodgers have covered the run line in 24 of their last 40 road games for +9.25 units and a 19% ROI. Find more MLB betting trends for Dodgers vs. Padres.
How to watch Dodgers vs Padres and game info
| Location | Petco Park, San Diego, CA |
| Date | Wednesday, May 20, 2026 |
| First pitch | 8:40 p.m. ET |
| TV | SportsNet LA, Padres.TV |
| Dodgers starting pitcher | Shohei Ohtani (3-2, 0.82 ERA) |
| Padres starting pitcher | Randy Vasquez (5-1, 2.68 ERA) |
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